https://doi.org/10.4081/jbr.2022.10441
The protective effect of Matricaria pubescens extracts against alloxan-induced hyperglycemia in rats
Submitted: March 3, 2022
Accepted: July 30, 2022
Published: August 4, 2022
Accepted: July 30, 2022
Abstract Views: 1126
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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The purpose of this research is to look into the potential inhibitory capacity of Matricaria pubescens methanolic extract (EMMP) on key diabetes-related enzymes in diabetic rats. A significant increase in serum and pancreatic α-amylase activity in untreated diabetic rats (Diab) of 61% and 75%, respectively, resulted in an 184% increase in blood glucose levels compared to controls. However, compared to untreated diabetic rats, treatment with the extract (Diab + EMMP) resulted in a significant decrease in pancreatic α-amylase activity in the pancreas (15%) and serum (28%). As a result, a significant reduction in blood sugar level has been observed, reaching 28%. When rats treated with EMMP were compared to untreated diabetics, the level of glycated hemoglobin (HbA1c) decreased by 28%. Furthermore, a significant increase in pancreatic serum lipase activity (59%) in untreated diabetic rats treated with EMMP resulted in a significant inhibition (21%). In diabetic rats treated with EMMP, β-cells were found to have a powerful protective effect. However, we observed body weight recovery in diabetic rats treated with EMMP.
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How to Cite
Khaled, K., Djilani, G. A., Hacen, L., Mohmed, M., & Azedinne, C. (2022). The protective effect of <em>Matricaria pubescens</em> extracts against alloxan-induced hyperglycemia in rats. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 95(2). https://doi.org/10.4081/jbr.2022.10441
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