The pioneers of modern lymphology in the early 20th century


We can state that modern lymphology was born from the pioneering work of the physicians of the first quarter of the 20th century. The turning point was definitely linked to the huge and precise work of the anatomists of the previous centuries and above all to the fine anatomical studies that resulted from the works of the second half of the 19th century. In the following decades, the possibility of specifically highlighting and studying lymphatic vessels and their physiology allowed the foundational step towards their clinical application and therefore the real understanding of pathologies and the first rudimentary therapeutic approaches. After the work of Von Recklingausen (1863) and Sappey (1876), after the technical completion of the then modern Gerota staining (1896) and the postulates on the physiology of the microcirculation put forward by Starling (1894), three centuries after the intuitions of Aselli (1626), we saw the definitive emancipation of Lymphology as an independent medical subject.



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Allen E. Lymphedema of the extremities. Classification, etiology and differential diagnosis: a study of three hundred cases. Arch Intern Med 1934:606-24. DOI:

Aselli G. De Lactibus sive Lacteis Venis Quarto Vasorum Mesaraicorum genere Novo Inven-to Gasparis Asellii Cremonensis Anatomici Ticinensis Dissertatio. Milano; 1627.

Mascagni P. Vasorum lymphaticorum corporis humani. Historia et ichonographia. Tip. Pazzi-ni Carli, Senis; 1787.

Von Recklingausen FD. Die Lymphgefässe und ihre Beziehung zum Bindegewebe The lymph vessels and their significance in connective tissue. Berlin: A. Hirschwald; 1862.

Sappey Ph. C. Des vaisseaux lymphatiques. Traité d’ Anatomie descriptive. Paris: A. De-lahaye & C.; 1876.

Starling EH. The influence of mechanical factors of lymph production. J Physiol 1894;16:224. DOI:

Gerota D. Zur Technik der lymphgefassinjektion. Eine neue Injektionsmasse der lymph-gefasse. Polychrome Injektion. Anat Anz 1896;12:216.

Cuneò D, Delamare G. Anatomie et histologie des lymphatiques de l’estomac. J Anat Physiol 1900.

Poierier V, Charpy A. Traité d’Anatomie Humaine, 2, f. 4, 1115, Paris, 1900.

Bartels P. Das Lymphgefassystem in Bardeleben’s Handbuch der Anatomie des Menschen. Ed. Fisher, Jena, 1909.

Idanov D.A. Die Lymphgefasse der Muskeln der oberen exstremitat des menschen. Proc IV Congr. Zool. Anat Histol U.S.S.R., Kiev, 1930.

Rouviere H. Anatomie des lymphatique de l’homme. Paris: Masson; 1932.

Defrise A. Primo saggio di ricerche radiografiche del Sistema Linfatico. Atti Soc Ital Ant I Congr Monit Zool Ital 1929;44:568.

Ottaviani G. Indagini radiologiche sul sistema linfatico. Arch Ital Anal Embr 1930:28-38.

Funaoka S. Der mechanismus der lymphbewegung.Untersuchung uber die physiologie der lymphbewegung. Arb Anat Inst Kaiserl Univ Kyoto 1930;1:1.

Carvalho R, Rodriguez A, De Sousa-Pereira S. Sour la methode radiographique de mise en evidence des lymphatiques chez le vivant. J Rad Électrol 1934;18:180.

Kynmonth JB. Lymphangiography in man. Clin Sci 1952;11:13.

Taylor GV, Kinmonth JB. Lymphatic circulation studies with radioactive plasma protein. Brit Med J 1957;1:133. DOI:

Milroy WF. Chronic hereditary edema: Milroy’s disease. JAMA 1928;Oct 20. DOI:

Osler W. The Principles and Practice of Medicine: Medical Textbook designed for the Use of Practitioners and Students of Medicine; 1892.

Milory WF. An undescribed variety of edema. New York Med J 1892;56:505.

Meige H. Dystrophie oedémateuse héréditaire. Presse Méd 1898;6.11:341-3.

Nielubovitz Olszewski W. Experimental lymphovenous anastomosis. Br J Surg 1968;55:449-51. DOI:

Degni M. New technique of lymphatic-venous anastomosis (buried type) for the treatment of lymphedema. VASA 1974;3:479-83.

Handley WS. Hunterian lectures on the surgery of the lymphatic system. Br Med J 1910;1:853-64. DOI:

Halsted WS. The swelling of the arm after operations for cancer of the breast: elephantiasis chirurgica, cause and treatment. Bull Johns Hopkins Hosp 1921;32:309.

Handley WS. Lymphangioplasty. Lancet 1908;1:783. DOI:

Lisfranc J. Clinique chirurgicale de l’Hôpital de la pitié. Paris: Béchet Jeune et Labé; 1841.

Lanz J. Er Öffnung neuer Abfuhrwege bei staung in Bauch und unteren extremitäten. Zbl. Chir. 1911;38:3.

Samokhvalov IM, Tyniankin NA, Reva VA, et al. Oppel V., The military surgical legacy of Vladimir Oppel (1872-1932). J Trauma Acute Care Surg 2013;74:1178-81. DOI:

Rosanow WN. Lymphangioplastik bei Elephantiasis. Langenbecks. Arch klin Chir 1912;99:645.

Kondoleon E. Die lymphableitung, alshelmittel bei chronischen oedemas mach Quetschung. München Med. Woch 1912;59:525.

Charles H. A system of treatment. London: J.A. Churchill; 1912.

Servelle M. La lymphangiectomie superficielle totale. Rev Chir 1947;85:294.

Sistrunk WE. Further experiences with the Kondoléon operation for elephantiasis. JAMA 1918;71:800-6. DOI:

Von Winewarter A. Die chirurgischen Krankheiten der Haut und des Zellgewebes. Stuttgart: Ferdinand Enke; 1892.

Hoffa A. Technik der Massage. Stuttgart: Ferdinand Enke; 1893.

Herman Bucholz C. A manual of therapeutic exercise and massage, designed for the use of physicians, students and masseurs. Philadelphia and New York: Lea & Febiger; 1917.

Kleen E. Massage and Medical Gymnastics. Churchill; 1918.

Vodder E. Manual de Lymphodreinage. Congresso di Estetica di “Santé e Beauté”, Paris, 1936.

Modern lymphology, 20th century.
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How to Cite
Macciò, A. (2021). The pioneers of modern lymphology in the early 20<sup>th</sup&gt; century. Veins and Lymphatics, 10(1).