Relationship between type 2 diabetes and pancreatic cancer


Submitted: 17 August 2017
Accepted: 28 September 2018
Published: 19 November 2018
Abstract Views: 732
PDF: 378
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Authors

  • M. Temel Yilmaz Diabetes Application and Research Center (DIYAM), Istanbul University, Sehremini; Department of Internal Medicine, Endocrinology and Metabolic Diseases Division, Istanbul Medicine Faculty, Istanbul University, Capa; Department of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Sehremini, Istanbul, Turkey.
  • Ali Osman Gürol Diabetes Application and Research Center (DIYAM), Istanbul University, Sehremini; Department of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Sehremini, Istanbul, Turkey.
Diabetes mellitus and cancer are conditions that constitute a serious problem for the health of the world’s population, and their co-existence in the same person is becoming increasingly common. Glucose metabolism and the presence of insulin in inflammatory situations appear to be the main factors driving this association, where hyperinsulinemia has been shown to contribute to an increase in risk of association between type 2 diabetes and cancer. Therefore, administering lower levels of exogenously administered insulin to patients with type 1 diabetes would decrease their risk of developing cancer when compared to patients with type 2 diabetes. The results from animal experiments seem promising in terms of pharmacological treatment.

Yilmaz, M. T., & Gürol, A. O. (2018). Relationship between type 2 diabetes and pancreatic cancer. Translational Medicine Reports, 2(1). https://doi.org/10.4081/tmr.7002

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