Genome-wide profiling of congenital insulin-like growth factor-1 deficient patients: translational implications in cancer prevention and metabolism

  • Haim Werner | hwerner@post.tau.ac.il Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv; Yoran Institute for Human Genome Research, Tel Aviv University, Tel Aviv, Israel.
  • Lena Lapkina Gendler Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Karthik Nagaraj Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Rive Sarfstein Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Zvi Laron Endocrinology and Diabetes Research Unit, Schneider Children’s Medical Center, Petah Tikva, Israel.

Abstract

Laron syndrome (LS) is a rare genetic disorder identified in the 1950s by Professor Zvi Laron. LS results from mutation of the growth hormone receptor (GH-R) gene, leading to congenital insulin-like growth factor-1 (IGF1) deficiency and dwarfism. Recent epidemiological studies have shown that LS patients do not develop cancer, emphasizing the crucial role of the IGF1 axis in cancer biology. Genome-wide profiling of LS patients conducted in our laboratory led to the identification of genes and signaling pathways that are over- or under-represented in LS compared to healthy controls of the same age range and ethnic group. Differentially expressed genes may be responsible for the association between lifetime low IGF1 values and protection from cancer. This experiment of nature may provide invaluable information that might translate into novel therapeutic approaches in modern oncology.

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Author Biography

Haim Werner, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv; Yoran Institute for Human Genome Research, Tel Aviv University, Tel Aviv

Haim Werner, Ph.D.
Professor and Lady Davis Chair in Biochemistry
Head, Department of Human Molecular Genetics and Biochemistry
Sackler School of Medicine
Tel Aviv University, Tel Aviv, Israel

 

Published
2017-07-19
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Section
Review Articles
Keywords:
Insulin-like growth factor-1 (IGF1), Growth hormone, Laron syndrome, Cancer protection, Genomic analysis
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How to Cite
Werner, H., Gendler, L. L., Nagaraj, K., Sarfstein, R., & Laron, Z. (2017). Genome-wide profiling of congenital insulin-like growth factor-1 deficient patients: translational implications in cancer prevention and metabolism. Translational Medicine Reports, 1(2). https://doi.org/10.4081/tmr.6657