Dear Authors,
a large number of reviewers in Europe and particularly in Italy, are clinicians: their commitment in the current public health emergency is aimed at helping and treating people. Our greatest thanks go to them.

We renew our commitment to guarantee you the peer-review process of your papers submitted to the Journal as soon as possible and we are confident we have your understanding for possible small delays.

The Editorial Board
The Publisher

EUROPEAN REFERENCE NETWORKS (ERNs): Could they become game-changers for patients with rare and complex diseases?


The European Reference Networks (ERNs) are innovative cross-border collaborative platforms with dedicated expertise centres and specialist doctors aiming to provide high-quality care to European patients with rare diseases whose diagnosis and treatment are often difficult, due to a lack of relevant knowledge and experience to manage these diseases locally.  The 4th  ERNs Conference, held in Brussels on November 21-22, 2018, presented the main clinical and organizational outcomes of the networks and promoted consultation between participants on existing challenges and scope for future improvements in their operation.