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Oxygen-ozone therapy is a medical practice validated in the literature by numerous international clinical studies. It has indications in many diseases and complications, alone or in combination with conventional therapies. In this work, a number of international clinical studies have been evaluated and those most relevant to pathologies of daily interest to the general practitioner (GP) have been selected to assess their cost/benefit ratio. It has been concluded that GPs and their patients can derive significant benefits from this medical practice, and GPs are ideally placed to assess which patients should receive this treatment.