TY - JOUR AU - Adekola, Hafeez Aderinsayo AU - Agbede, Olajide Olubunmi AU - Abdullahi, Idris Nasir AU - Olayemi, Lawal O. AU - Emeribe, Anthony Uchenna AU - Dangana, Amos AU - Yunusa, Thairu PY - 2019/11/06 Y2 - 2024/03/29 TI - Assessment of serum Aspergillus galactomannan expression and associated risk factors among patients living with HIV at Ilorin, Nigeria JF - Microbiologia Medica JA - Microbiol Med VL - 34 IS - 2 SE - Original Articles DO - 10.4081/mm.2019.8158 UR - https://www.pagepressjournals.org/mm/article/view/8158 SP - AB - <p>Invasive pulmonary aspergillosis still constitutes a diagnostic challenge for clinicians due to its non-specific symptoms. HIV infection represents one of the major risk factors due to the progressive failure of the immune system. In this study, <em>Aspergillus</em> serum galactomannan enzyme linked immunosorbent assay was used for the diagnosis of invasive pulmonary aspergillosis in patients living with HIV/AIDS attending University of Ilorin Teaching Hospital Antiretroviral Therapy Clinic, Nigeria. Blood samples were collected from 97 patients affected by HIV/AIDS. Age range of the study population was between 0 and 79 years. Length of the study: 3 weeks. Three out of the 97 samples were positive for the galactomannan assay with an optical density index of 1.1, 0.9 and 1.1 using the 0.5 cut-off optical density value; the concentration level of galactomannan antigen was therefore 2.20 μg/L, 1 μg/L and 2.19 μg/L, respectively. A prevalence of 3.1 % (3/97) was detected; all positive participants have been on ART for more than 3 years (P&lt;0.0001), and 2 out of the 3 had CD4 count higher than 200 cells/mm3 (P&lt;0.0001). Serum <em>Aspergillus</em> galactomannan assay is less invasive for patients and diagnosis can be made in a relatively shorter time compared to other techniques used in diagnosing invasive pulmonary aspergillosis.</p> ER -