@article{Maioli_Coppo_Barbieri_Canepa_Gualco_Pruzzo_Debbia_Marchese_2010, title={In vitro activity of tigecycline against 313 Gram-positive and Gram-negative clinical isolates}, volume={25}, url={https://www.pagepressjournals.org/mm/article/view/mm.2010.2482}, DOI={10.4081/mm.2010.2482}, abstractNote={Objectives. In this study the in vitro activity of tigecycline, member of a new class of antimicrobial agents, the glycylcyclines, was evaluated against clinical isolates collected in Italy. Study Design. A total of 313 clinical pathogens were collected and identified in our Institution during 2007-2008. Minimum inhibitory concentrations (MICs) of the antimicrobial agents were determined by the CLSI (2007) recommended broth microdilution method. Results. Globally 205 Gram-negative and 108 Gram-positive pathogens were evaluated.Tigecycline demonstrated excellent inhibitory activity against Acinetobacter spp., H. influenzae, E. coli, Enterococcus spp., S. aureus, S. agalactiae and S. pneumoniae with MIC90 ≤1mg/l. Conclusion. Tigecycline exhibited potent in vitro antibacterial activity (comparable to or greater than most commonly employed antimicrobials) against both Gram-positive and negative clinical pathogens.These data suggest that tigecycline, with an expanded broad-spectrum antimicrobial activity, may be an effective empiric therapeutic option for the treatment of serious infections caused by clinically relevant pathogens.}, number={1}, journal={Microbiologia Medica}, author={Maioli, Elisabetta and Coppo, Erika and Barbieri, Ramona and Canepa, Elisabetta and Gualco, Laura and Pruzzo, Carla and Debbia, Eugenio A. and Marchese, Anna}, year={2010}, month={Mar.} }