In vitro activity of tigecycline against 313 Gram-positive and Gram-negative clinical isolates

  • Elisabetta Maioli |
  • Erika Coppo
  • Ramona Barbieri
  • Elisabetta Canepa
  • Laura Gualco
  • Carla Pruzzo
  • Eugenio A. Debbia
  • Anna Marchese


Objectives. In this study the in vitro activity of tigecycline, member of a new class of antimicrobial agents, the glycylcyclines, was evaluated against clinical isolates collected in Italy. Study Design. A total of 313 clinical pathogens were collected and identified in our Institution during 2007-2008. Minimum inhibitory concentrations (MICs) of the antimicrobial agents were determined by the CLSI (2007) recommended broth microdilution method. Results. Globally 205 Gram-negative and 108 Gram-positive pathogens were evaluated.Tigecycline demonstrated excellent inhibitory activity against Acinetobacter spp., H. influenzae, E. coli, Enterococcus spp., S. aureus, S. agalactiae and S. pneumoniae with MIC90 ≤1mg/l. Conclusion. Tigecycline exhibited potent in vitro antibacterial activity (comparable to or greater than most commonly employed antimicrobials) against both Gram-positive and negative clinical pathogens.These data suggest that tigecycline, with an expanded broad-spectrum antimicrobial activity, may be an effective empiric therapeutic option for the treatment of serious infections caused by clinically relevant pathogens.



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Original Articles
tigecycline, broad-spectrum activity, antibiotic-resistance
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How to Cite
Maioli, E., Coppo, E., Barbieri, R., Canepa, E., Gualco, L., Pruzzo, C., Debbia, E. A., & Marchese, A. (2010). In vitro activity of tigecycline against 313 Gram-positive and Gram-negative clinical isolates. Microbiologia Medica, 25(1).

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