Comparison of three assays currently used for diagnosis of legionellosis

Maria Chiucini; Anna Fabio; Marisa Meacci; Barbara Meccugni; Valentina Gilioli; Valeria Petocchi; Giuliana Fabio; Anna Maria Teresa Sabbatini; Sara Tagliazucchi; Sandra Mattioli; Fabio Rumpianesi

doi:10.4081/mm.2010.2407

Comparison of three assays currently used for diagnosis of legionellosis

https://doi.org/10.4081/mm.2010.2407

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Vol. 25 No. 4 (2010)

Submitted: 14 February 2014
Accepted: 14 February 2014

Published: 31 December 2010

Legionella pneumophila, cultures, urinary antigen, antibody research

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Authors

The laboratory diagnosis of Legionnaires’ disease is extremely complex due to the difficulty of isolating and identifying the etiological agent in a short time and also for the frequent late appearance of antibodies. For this reason it should use not only the cultures but also other diagnostic tests such as urinary antigen and antibody research. Our study evaluated the performance of these methods.We calculated the positive predictive value (PPV) and negative predictive value (NPV), sensitivity and specificity of each test.

Chiucini, M., Fabio, A., Meacci, M., Meccugni, B., Gilioli, V., Petocchi, V., Fabio, G., Sabbatini, A. M. T., Tagliazucchi, S., Mattioli, S., & Rumpianesi, F. (2010). Comparison of three assays currently used for diagnosis of legionellosis. Microbiologia Medica, 25(4). https://doi.org/10.4081/mm.2010.2407