Significance of the “isolated EBNA-1 IgG” pattern in past EBV infection

Abstract

The ELISA screening detection of anti-EBNA-1 IgG in the absence of VCA IgG and IgM is rare but may lead to doubts in interpretation.We used immunoblotting to characterise 23 serum samples with “isolated EBNA-1 IgG” upon ELISA screening, and found that all showed VCA anti-p23 and 13 (56.6%) also showed VCA anti-p18 antibodies. It therefore seems impossible for a sample to show anti-EBNA-1 IgG without anti-VCA IgG antibodies. Furthermore, although anti-p18 antibodies are thought to develop later and therefore considered to be markers of past infection, about 1% of all previously infected EBNA-1 IgG-positive patients do not have them.

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Published
2009-03-31
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Section
Short Communications
Keywords:
immunoblotting, EBNA-1, EBV, mononucleosis, serological pattern
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How to Cite
De Paschale, M., Cagnin, D., Manco, M. T., & Clerici, P. (2009). Significance of the “isolated EBNA-1 IgG” pattern in past EBV infection. Microbiologia Medica, 24(1). https://doi.org/10.4081/mm.2009.2553

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