Isolation of multidrug-resistant Enterobacter cloacae and comparison among clavulanate-tazobactam and sulbactam-synergy by using a double-disk synergy test

Vincenzo Savini; Fabio Febbo; Andrea Balbinot; Marzia Talia; Chiara Catavitello; Assunta Manna; Fabio Di Berardino; Francesca Fioritoni; Daniela Carlino; Giovanni Di Bonaventura; Domenico D’Antonio

doi:10.4081/mm.2008.2587

Isolation of multidrug-resistant Enterobacter cloacae and comparison among clavulanate-tazobactam and sulbactam-synergy by using a double-disk synergy test

https://doi.org/10.4081/mm.2008.2587

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Vol. 23 No. 2 (2008)

Submitted: 17 February 2014
Accepted: 17 February 2014

Published: 30 June 2008

Enterobacter cloacae, ESBLs, double-disk synergy test

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False negative results of double-disk synergy test with Enterobacter cloacae are common, as AmpC-enzymes may mask ESBLs elaboration. We increased the sensitivity of the method by using both clavulanate- and tazobactam/sulbactam; hence, we suggest to use all the three inhibitors to screen ESBLs in AmpC ß-lactamases producing organisms.

Savini, V., Febbo, F., Balbinot, A., Talia, M., Catavitello, C., Manna, A., Di Berardino, F., Fioritoni, F., Carlino, D., Di Bonaventura, G., & D’Antonio, D. (2008). Isolation of multidrug-resistant Enterobacter cloacae and comparison among clavulanate-tazobactam and sulbactam-synergy by using a double-disk synergy test. Microbiologia Medica, 23(2). https://doi.org/10.4081/mm.2008.2587