Assessment of serum Aspergillus galactomannan expression and associated risk factors among patients living with HIV at Ilorin, Nigeria

  • Hafeez Aderinsayo Adekola Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, University of Ilorin, Nigeria.
  • Olajide Olubunmi Agbede Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, University of Ilorin, Nigeria.
  • Idris Nasir Abdullahi | eedris888@yahoo.com Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria.
  • Lawal O. Olayemi 3Department of Medicine, National University of Samoa, Samoa.
  • Anthony Uchenna Emeribe Department of Medical Laboratory Science, University of Calabar, Nigeria.
  • Amos Dangana Department of Medical Laboratory Services, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.
  • Thairu Yunusa Department of Medical Microbiology and Parasitology, University of Abuja, Nigeria.

Abstract

Invasive pulmonary aspergillosis still constitutes a diagnostic challenge for clinicians due to its non-specific symptoms. HIV infection represents one of the major risk factors due to the progressive failure of the immune system. In this study, Aspergillus serum galactomannan enzyme linked immunosorbent assay was used for the diagnosis of invasive pulmonary aspergillosis in patients living with HIV/AIDS attending University of Ilorin Teaching Hospital Antiretroviral Therapy Clinic, Nigeria. Blood samples were collected from 97 patients affected by HIV/AIDS. Age range of the study population was between 0 and 79 years. Length of the study: 3 weeks. Three out of the 97 samples were positive for the galactomannan assay with an optical density index of 1.1, 0.9 and 1.1 using the 0.5 cut-off optical density value; the concentration level of galactomannan antigen was therefore 2.20 μg/L, 1 μg/L and 2.19 μg/L, respectively. A prevalence of 3.1 % (3/97) was detected; all positive participants have been on ART for more than 3 years (P<0.0001), and 2 out of the 3 had CD4 count higher than 200 cells/mm3 (P<0.0001). Serum Aspergillus galactomannan assay is less invasive for patients and diagnosis can be made in a relatively shorter time compared to other techniques used in diagnosing invasive pulmonary aspergillosis.

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Author Biography

Thairu Yunusa, Department of Medical Microbiology and Parasitology, University of Abuja

Department of Medical Microbiology

University of Abuja, Abuja, Nigeria

Published
2019-11-06
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Original Articles
Keywords:
Pulmonary Aspergillosis, HIV co-infection, Mycosis, Immunosuppression
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How to Cite
Adekola, H., Agbede, O., Abdullahi, I., Olayemi, L., Emeribe, A., Dangana, A., & Yunusa, T. (2019). Assessment of serum Aspergillus galactomannan expression and associated risk factors among patients living with HIV at Ilorin, Nigeria. Microbiologia Medica, 34(2). https://doi.org/10.4081/mm.2019.8158

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