Antibiotic resistance of bacteria responsible of acute respiratory tract infections in children

  • Makhtar Camara | camaramakhtar@yahoo.fr Bacteriology and Virology Laboratory, Le Dantec Teaching Hospital, Dakar, Senegal.
  • Assane Dieng Bacteriology and Virology Laboratory, Le Dantec Teaching Hospital, Dakar, Senegal.
  • Abdoulaye Diop Bacteriology and Virology Laboratory, Le Dantec Teaching Hospital, Dakar, Senegal.
  • Amadou Diop Bacteriology and Virology Laboratory, Le Dantec Teaching Hospital, Dakar, Senegal.
  • Amadou Diop Bacteriology and Virology Laboratory, Albert Royer teaching Hospital, Dakar, Senegal.
  • Djibril Boiro Paediatric Unit, Abass NDAO Teaching Hospital, Dakar, Senegal.
  • Jean Baptisse Niokhor Diouf Paediatric Unit, Roi Baudouin Hospital, Dakar, Senegal.
  • Amary Fall Medical Virology Unit, Institute Pasteur, Dakar, Senegal.
  • Ousmane Ndiaye Paediatric Unit, Abass NDAO Teaching Hospital, Dakar, Senegal.
  • Mbayame Niang Medical Virology Unit, Institute Pasteur, Dakar, Senegal.
  • Cheikh Saad Bouh Boye Bacteriology and Virology Laboratory, Le Dantec Teaching Hospital, Dakar, Senegal.

Abstract

Background and aims. Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis are the most common causative agents of acute respiratory tract infections (RTIs). The objective of this study was to assess their susceptibility to several antibiotics.
Materials and methods. A total of 58 strains (16 S. pneumoniae, 19 H. influenzae and 23 M. catarrhalis) were isolated from samples collected in two paediatric centres, and their susceptibility to commonly used antibiotics tested by E-test.
Results. Among H. influenzae isolates, 10.5% were resistant to ampicillin (all β-lactamase-positive), and 88.9% were susceptible to cefaclor. High β-lactam resistance rates (penicillin: 31.3% and cephalosporins: 18.7 to 31.3%) had been observed among S. pneumonia strains. Only 50% of isolates were susceptible to azithromycine. 91.3% of M. catarrhalis isolates β-lactamases producers were resistant to ampicillin while susceptible to the most tested antibiotics.
Conclusions. Except M. catarrhalis β-lactamases producing strains, frequency of antibiotic resistance was mainly observed among S. pneumoniae, and to a lesser extent among H. influenzae clinical isolates, suggesting the need for continuous surveillance of antimicrobial resistance patterns in the management of RTIs.

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Published
2017-03-28
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Section
Original Articles
Supporting Agencies
GlaxoSmithKline (GSK)
Keywords:
Respiratory tract infections, Haemophilus influenza, Moraxella catarrhalis, Streptococcus pneumoniae, Antibiotic resistance
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How to Cite
Camara, M., Dieng, A., Diop, A., Diop, A., Diop, A., Boiro, D., Diouf, J., Fall, A., Ndiaye, O., Niang, M., & Boye, C. (2017). Antibiotic resistance of bacteria responsible of acute respiratory tract infections in children. Microbiologia Medica, 32(1). https://doi.org/10.4081/mm.2017.6489

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