Synergistic effect of clinically available β lactamases inhibitors on cefiderocol activity against carbapenemase producing Gram negative organisms

Published: 11 April 2023
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Citations

Kazmierczak KM, Tsuji M, Wise MG, Hackel M, Yamano Y, Echols R, et al In vitro activity of cefiderocol a siderophore
cephalosporin, against a recent collection of clinically relevant carbapenem non susceptible Gram negative bacilli, including
serine carbapenemase and metallo β lactamase producing isolates (SIDERO WT 2014 Study) Int J Antimicrob Agents 2019;53(177):84 DOI: https://doi.org/10.1016/j.ijantimicag.2018.10.007
Karakonstantis S, Rousaki M, Kritsotakis EI Cefiderocol Systematic Review of Mechanisms of Resistance, Heteroresistance and In
Vivo Emergence of Resistance Antibiotics 2022;11:723. DOI: https://doi.org/10.3390/antibiotics11060723
The European Committee on Antimicrobial Susceptibility Testing Guidance document on broth microdilution testing of
cefiderocol 2020 Available at: http :://www eucast org
Doern CD When does 2 plus 2 equal 5 A review of antimicrobial synergy testing J Clin Microbiol 2014;52(4124):8. DOI: https://doi.org/10.1128/JCM.01121-14
NCCLS 1999 Methods for determining bactericidal activity of antimicrobial agents approved guideline Document M 26 A
National Committee for Clinical Laboratory Standards, Wayne, PA

How to Cite

Bianco, G., Comini, S., Gaibani, P., Boattini, M., Banche, G., Costa, C., Nordmann, P., & Cavallo, R. (2023). Synergistic effect of clinically available β lactamases inhibitors on cefiderocol activity against carbapenemase producing Gram negative organisms. Microbiologia Medica, 38(1). https://doi.org/10.4081/mm.2023.11367