CADASIL: A HEREDITARY CEREBROVASCULAR DISEASE AS MODEL FOR COMMON VASCULAR ISCHEMIC DEMENTIA
AbstractTogether with Alzheimer’s disease, vascular dementia (VD) is the most frequent cause of progressive cognitive deterioration. The most common form of VD, subcortical vascular ischemic disease of the brain (SVIDB), affects elderly subjects who generally have a medical history of common vascular risk factors, especially hypertension. The clinical picture is generally progressive or stepwise due to recurrent stroke, and besides cognitive deterioration includes depression and problems with walking, swallowing and sphincter control. Magnetic resonance imaging (MRI), which is crucial in the diagnosis and follow-up of SVIDB, shows small subcortical infarcts (ischemic lacunae) and diffuse vascular damage in the
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Copyright (c) 2012 Maria Teresa Dotti
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