SELECTIVE INFLUENCES IN THE B-CELL RECEPTOR IMMUNOGLOBULIN HEAVY AND LIGHT CHAIN IN HAIRY CELL LEUKEMIA


https://doi.org/10.4081/jsas.2009.352
Vol. 1 No. 1 (2009)
Submitted: 10 January 2012
Accepted: 10 January 2012
Published: 10 January 2012
Abstract Views: 709
PDF: 952
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

  • F. Forconi
    info@pagepress.org
    Ematology Unit, Dept. of Clinical Medicine and Immunological Sciences, University of Siena, Italy.
  • T. Amato Ematology Unit, Dept. of Clinical Medicine and Immunological Sciences, University of Siena, Italy.
  • E. Sozzi Ematology Unit, Dept. of Clinical Medicine and Immunological Sciences, University of Siena, Italy.
  • E. Cencini Ematology Unit, Dept. of Clinical Medicine and Immunological Sciences, University of Siena, Italy.
  • D. Raspadori Ematology Unit, Dept. of Clinical Medicine and Immunological Sciences, University of Siena, Italy.
  • F. Lauria Ematology Unit, Dept. of Clinical Medicine and Immunological Sciences, University of Siena, Italy.
Hairy cell leukemia (HCL) is a rare, chronic B-cell neoplasm characterized by leukemic hairy cells (HCs) present in blood, bone marrow, and splenic red pulp, with atrophy of white pulp. Lymph node involvement is infrequent. HCL is typically associated with markers of activation, that include expression of CD25, CD11c, FMC7, and CD103 at high intensity. A distinctive feature of HCL is expression of multiple surface immunoglobulin (sIg) isotypes, although its prevalence in HCL is not fully mapped.

Forconi, F., Amato, T., Sozzi, E., Cencini, E., Raspadori, D., & Lauria, F. (2012). SELECTIVE INFLUENCES IN THE B-CELL RECEPTOR IMMUNOGLOBULIN HEAVY AND LIGHT CHAIN IN HAIRY CELL LEUKEMIA. Journal of the Siena Academy of Sciences, 1(1), 18–26. https://doi.org/10.4081/jsas.2009.352

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC