SMALL MOLECULES SOLVING BIG PROBLEMS: PRESENT AND FUTURE OF DRUG DISCOVERY

  • Anna Lucia Fallacara Department of Biotechnology Chemistry and Pharmacy, University of Siena, Italy.
  • Iuni Margaret Laura Tris Department of Biotechnology Chemistry and Pharmacy, University of Siena, Italy.
  • Amalia Belfiore Department of Biotechnology Chemistry and Pharmacy, University of Siena, Italy.
  • Maurizio Botta | botta.maurizio@gmail.com Department of Biotechnology Chemistry and Pharmacy, University of Siena, Italy; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, United States.

Abstract

The Drug development process has undergone a great change over the years. The way, from haphazard discovery of new natural products with a potent biological activity to a rational design of small molecule effective against a selected target, has been long and sprinkled with difficulties. The oldest drug development models are widely perceived as opaque and inefficient, with the cost of research and development continuing to rise even if the production of new drugs remains constant. The present paper, will give an overview of the principles, approaches, processes, and status of drug discovery today with an eye towards the past and the future.

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Published
2018-10-12
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Section
Lectio Magistralis
Keywords:
drug development, in silico drug design, ADME, HIV, tyrosine kinase
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How to Cite
Fallacara, A., Tris, I., Belfiore, A., & Botta, M. (2018). SMALL MOLECULES SOLVING BIG PROBLEMS: PRESENT AND FUTURE OF DRUG DISCOVERY. Journal of the Siena Academy of Sciences, 9(1). https://doi.org/10.4081/jsas.2017.7876