https://doi.org/10.4081/jbr.2021.9954

Omega-3 PUFAs and gut microbiota: A preventive approach for colorectal cancer

Vol. 94 No. 2 (2021)
Submitted: July 6, 2021
Accepted: November 20, 2021
Published: November 24, 2021
ω-3 PUFAs, colorectal cancer, prevention, gut microbiota, Mucosal Associated Lymphatic Tissue (MALT)
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Authors

Marco Giammanco
Department of Surgery, Oncologicical and Stomatological Sciences (Di.Chir.On.S), University Hospital Policlinico Paolo Giaccone of Palermo, Palermo, Italy.
Margherita Mazzola
margheritamazzola@hotmail.it
Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, (BIND), University Hospital Policlinico Paolo Giaccone of Palermo, Palermo, Italy.
Manfredi Marco Giammanco
Department of Human Pathology in Adulthood and Childhood “G. Barresi”, Medical School University of Messina, Messina, Italy.
Giovanni Tomasello
Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, (BIND), University Hospital Policlinico Paolo Giaccone of Palermo, Palermo, Italy.
Francesco Carini
Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, (BIND), University Hospital Policlinico Paolo Giaccone of Palermo, Palermo, Italy.

The influence of diet on the composition of the intestinal microbiota and related pathologies has been known for some time. Some classes of nutrients, such as fatty acids belonging to the omega 3 series, have particular effects on the bacteria that make up the intestinal microbiota. ω-3 PUFAs affect the gut microbiota in three different ways: by modulating the type and abundance of intestinal bacteria, by regulate SCFAs levels, and by alter the levels of proinflammatory mediators. Through these modalities, ω-3 PUFAs could be useful for the prevention of intestinal diseases such as Colorectal Cancer (CRC). The ability of ω-3 PUFAs to modulate the intestinal inflammatory response, to preserve the integrity of the intestinal mucosa and to modulate the bacterial composition of the intestine, could be useful as a preventive strategic approach to hinder the development of CRC.

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How to Cite

Giammanco, M., Mazzola, M., Giammanco, M. M., Tomasello, G., & Carini, F. (2021). Omega-3 PUFAs and gut microbiota: A preventive approach for colorectal cancer. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 94(2). https://doi.org/10.4081/jbr.2021.9954

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