Effect of exercise training on gene expression of adiponectin and its receptors in testicles and sex hormones in diabetic rats
Adiponectin and its receptors are expressed in the male reproductive system, which play a role in regulating male sex hormones and fertility. Diabetes was induced by Streptozotocin-Nicotinamide (STZ-NA i.p) in rats and after performing the trainings, adiponectin gene expression and its receptors in the testis were evaluated using real time PCR, and blood serum was then used in order to assess FSH, LH and testosterone. The STZ-NA significantly increased the fasting blood glucose, gene expression of adiponectin AdipoR1 in the testicles of diabetic rats. A significant reduction in serum testosterone and LH levels were observed in the diabetic group. Resistance and endurance training decreased blood glucose, adiponectin and AdipoR1 gene, and also increased the serum testosterone and LH levels in diabetic rats. Overall, our data suggest the role played by training in improve expression of adiponectin and AdipoR1 gene by increasing the serum testosterone and LH levels in type 2 diabetic rats.
Vaziri P, Vahedi M, Abdollahzadeh S, et al. Evaluation of salivary albumin in diabetic patients. Iranian J Public Health 2009;38:54-9.
Boyle JP, Honeycutt AA, Narayan KV, et al. Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the US. Diabetes Care 2001;24:1936-40. DOI: https://doi.org/10.2337/diacare.24.11.1936
Arulrayan N, Rangasamy S, James E, Pitchai D. A database for medicinal plants used in the treatment of diabetes and its secondary complications. Bioinformation 2007;2:22-3. DOI: https://doi.org/10.6026/97320630002022
Ramalho-Santos J, Amaral S, Oliveira PJ. Diabetes and the impairment of reproductive function: possible role of mitochondria and reactive oxygen species. Current Diabetes Rev 2008;4:46-54. DOI: https://doi.org/10.2174/157339908783502398
Roessner C, Paasch U, Kratzsch J, et al. Sperm apoptosis signalling in diabetic men. Reprod Biomed Online 2012;25:292-9. DOI: https://doi.org/10.1016/j.rbmo.2012.06.004
Chandrashekar V, Bartke A. The impact of altered insulin-like growth factor-I secretion on the neuroendocrine and testicular functions. Minerva Ginecol 2005;57:87-97.
Yang WS, Lee WJ, Funahashi T, et al. Plasma adiponectin levels in overweight and obese Asians. Obesity Res 2002;10:1104-10. DOI: https://doi.org/10.1038/oby.2002.150
Karbowska J, Kochan Z. Role of adiponectin in the regulation of carbohydrate and lipid metabolism. J Physiol Pharmacol 2006;57:103.
Caminos J, Nogueiras R, Gaytán F, et al. Novel expression and direct effects of adiponectin in the rat testis. Endocrinology 2008;149:3390-402. DOI: https://doi.org/10.1210/en.2007-1582
Yang B, Chen L, Qian Y, et al. Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats. Biochem Biophys Res Comm 2006;341:209-17. DOI: https://doi.org/10.1016/j.bbrc.2005.12.172
Martin LJ. Implications of adiponectin in linking metabolism to testicular function. Endocrine 2014;46:16-28. DOI: https://doi.org/10.1007/s12020-013-0102-0
Boudou P, Sobngwi E, Mauvais-Jarvis F, et al. Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men. Eur J Endocrinol 2003;149:421-4. DOI: https://doi.org/10.1530/eje.0.1490421
Simpson KA, Singh MAF. Effects of exercise on adiponectin: a systematic review. Obesity 2008;16:241-56. DOI: https://doi.org/10.1038/oby.2007.53
Satheesh MA, Pari L. Effect of pterostilbene on lipids and lipid profiles in streptozotocin-nicotinamide induced type 2 diabetes mellitus. J Applied Biomed 2008;6:31-7. DOI: https://doi.org/10.32725/jab.2008.005
Parastesh M, Heidarianpour A. Effects of endurance training on the serum level of sex hormones and sperm parameters after diabetic induction by streptozotocin-nicotinamide. J Shahrekord Uuniversity Med Sci 2017;19.
Parastesh M, Saremi A, Ahmadi A, Kaviani M. The effect of aerobic training on serum levels of adiponectin, hypothalamic-pituitary-gonadal axis and sperm quality in diabetic rats. Urology J 2019;16:592-7.
Parastesh M, Heidarianpour A, Bayat M, Saremi A. Effects of Resistance Training on Serum Level of Reproductive Hormones and Sperm Parameters in Type 2 Diabetes Rats. J Arak University Med Sci 2016;19:26-36.
Du Plessis SS, Kashou A, Vaamonde D, Agarwal A. Is there a link between exercise and male factor infertility. Open Reprod Sci J 2011;3:105-13. DOI: https://doi.org/10.2174/1874255601103010105
Cnop M, Havel P, Utzschneider K, et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 2003;46:459-69. DOI: https://doi.org/10.1007/s00125-003-1074-z
Broedl UC, Lehrke M, Fleischer-Brielmaier E, et al. Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome. Cardiovascular Diabetol 2006;5:11. DOI: https://doi.org/10.1016/S1567-5688(06)80562-3
Körner A, Kratzsch J, Gausche R, et al. New predictors of the metabolic syndrome in children—role of adipocytokines. Pediatric Research 2007;61:640. DOI: https://doi.org/10.1203/01.pdr.0000262638.48304.ef
Kadivar A, Khoei HH, Hassanpour H, et al. Correlation of adiponectin mRNA abundance and its receptors with quantitative parameters of sperm motility in rams. International J Fertil Steril 2016;10:127.
Ocon-Grove OM, Krzysik-Walker SM, Maddineni SR, Hendricks GL, Ramachandran R. Adiponectin and its receptors are expressed in the chicken testis: influence of sexual maturation on testicular ADIPOR1 and ADIPOR2 mRNA abundance. Reproduction 2008;136:627-38. DOI: https://doi.org/10.1530/REP-07-0446
Amaral S, Moreno AJ, Santos MS, Seiça R, Ramalho-Santos J. Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetes. Theriogenology 2006;66:2056-67. DOI: https://doi.org/10.1016/j.theriogenology.2006.06.006
Alves M, Martins A, Rato L, Moreira P, Socorro S, Oliveira P. Molecular mechanisms beyond glucose transport in diabetes-related male infertility. Biochim Biophys Acta 2013;1832:626-35. DOI: https://doi.org/10.1016/j.bbadis.2013.01.011
Pitteloud N, Hardin M, Dwyer AA, et al. Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men. J Clini Endocrinol Metab 2005;90:2636-41. DOI: https://doi.org/10.1210/jc.2004-2190
Manders R, Van JD. Low-intensity exercise reduces the prevalence of hyperglycemia in type 2 diabetes. Med Sci Sports Exerc 2010;42:219-25. DOI: https://doi.org/10.1249/MSS.0b013e3181b3b16d
Garekani ET, Mohebbi H, Kraemer RR, Fathi R. Exercise training intensity/volume affects plasma and tissue adiponectin concentrations in the male rat. Peptides 2011;32:1008-12. DOI: https://doi.org/10.1016/j.peptides.2011.01.027
Tremblay MS, Copeland JL, Van Helder W. Influence of exercise duration on post-exercise steroid hormone responses in trained males. European J Appl Physiol 2005;94:505-13. DOI: https://doi.org/10.1007/s00421-005-1380-x
Kraemer WJ, Ratamess NA. Hormonal responses and adaptations to resistance exercise and training. Sports Med 2005;35:339-61. DOI: https://doi.org/10.2165/00007256-200535040-00004
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