Effect of exercise training on gene expression of adiponectin and its receptors in testicles and sex hormones in diabetic rats

  • Zahra Nadi Department of Anatomy, School of Medicine, Arak University, Arak, Iran, Islamic Republic of.
  • Mohammad Bayat Department of Anatomy, School of Medicine, Arak University, Arak, Iran, Islamic Republic of.
  • Hadi Karami Department of Molecular Medicine and Biotechnology, Faculty of Medicine, Arak University, Arak, Iran, Islamic Republic of.
  • Mohamad Parastesh Department of Sport Physiology, Faculty of Sport Sciences, Arak University, Arak, Iran, Islamic Republic of.
  • Parvin Dokht Bayat | Dr.bayat@arakmu.ac.ir Department of Anatomy, School of Medicine, Arak University, Arak, Iran, Islamic Republic of.


Adiponectin and its receptors are expressed in the male reproductive system, which play a role in regulating male sex hormones and fertility. Diabetes was induced by Streptozotocin-Nicotinamide (STZ-NA i.p) in rats and after performing the trainings, adiponectin gene expression and its receptors in the testis were evaluated using real time PCR, and blood serum was then used in order to assess FSH, LH and testosterone. The STZ-NA significantly increased the fasting blood glucose, gene expression of adiponectin AdipoR1 in the testicles of diabetic rats. A significant reduction in serum testosterone and LH levels were observed in the diabetic group. Resistance and endurance training decreased blood glucose, adiponectin and AdipoR1 gene, and also increased the serum testosterone and LH levels in diabetic rats. Overall, our data suggest the role played by training in improve expression of adiponectin and AdipoR1 gene by increasing the serum testosterone and LH levels in type 2 diabetic rats.



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Original Articles
Diabetes, adiponectin, Adipor1 and Adipor2, sex hormones, training
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How to Cite
Nadi, Z., Bayat, M., Karami, H., Parastesh, M., & Bayat, P. D. (2021). Effect of exercise training on gene expression of adiponectin and its receptors in testicles and sex hormones in diabetic rats. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 94(1). https://doi.org/10.4081/jbr.2021.9287