Inhibitory effect of plant extracts on the cytotoxicity of eurytele nematocysts from Pelagia noctiluca

  • Rossana Morabito Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
  • Laura Cornara Department of Earth, Environment and Life Sciences, University of Genova, Genova, Italy.
  • Giuseppina La Spada Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
  • Angela Marino Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
  • Gian Luigi Mariottini | Gian.Luigi.Mariottini@unige.it Department of Earth, Environment and Life Sciences, University of Genova, Genova, Italy.
  • Alessia Remigante Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
  • Bruno Burlando Department of Pharmacy, University of Genova, Genova, Italy.

Abstract

Some species of Cnidarians, well known venomous organisms, are able to induce serious health problems as well as economic and social trouble. A lot of data show that cnidarian venoms can be cytotoxic to cultured cells. Therefore, a priority of the research is to find tools which could counteract the damaging activity of venoms. In this connection, the modulatory effects exerted by extracts of plants Ananas comosus (L.) and Carica papaya (L.) on cytotoxicity of heterotrichous microbasic eurytele nematocysts isolated from the jellyfish Pelagia noctiluca was evaluated. The nematocyst extract induced strong cytotoxicity at highest tested doses with reduction of cell survival below 40% and IC50 value of 40×103 nematocysts/mL. Both plant extracts significantly improved the survival of cells, so that the IC50 resulted 74×103 and 100×103 nematocysts/mL in the presence of A. comosus and C. papaya extracts, respectively, both used at 10 and 100 μg/mL. Taking into account that heterotrichous microbasic eurytele nematocysts are present mainly in tentacles, which Pelagia noctiluca utilizes both for predation and defence, this result is particularly interesting from both ecological and sanitary point of view and demonstrates the potential of these plants extracts against cnidarian venoms.

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Published
2021-01-13
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Original Articles
Keywords:
Jellyfish, nematocysts, cytoxicity, plant extracts, venom inactivation
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How to Cite
Morabito, R., Cornara, L., La Spada, G., Marino, A., Mariottini, G. L., Remigante, A., & Burlando, B. (2021). Inhibitory effect of plant extracts on the cytotoxicity of eurytele nematocysts from <em>Pelagia noctiluca</em&gt;. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 93(2). https://doi.org/10.4081/jbr.2020.9136

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