Elevated levels of proinflammatory and anti-inflammatory cytokines in patients with bladder cancer depending on a tumor stage

Submitted: October 21, 2019
Accepted: February 18, 2020
Published: July 9, 2020
Abstract Views: 715
PDF: 391
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Bladder Cancer (BC) is a common disease worldwide. Chronic inflammation is one of the key mechanisms for the development of BC. This study enrolled 40 patients. Preoperative plasma levels of IL-1β, IL-4, IL-6, IL-10, IL-12β, TNF-α and IFN-γ were determined by ELISA. In our study, we observed diverse changes in the levels of cytokines in patients with BC Stage I, II, III and IV. The levels of IL-1β was increased for stage I, stage II, and stage III. The level of TNF-α was increased for stage II, stage III, stage IV. The levels of IL-4, IL-6, IL-10 and IL-12β were increased in patients with stage III and IV only. The levels of IFN- γ declined for stage II, stage III and stage IV with the lowest levels in patients with Stage IV. In our study, we investigated alteration in levels of Th-1 and Th-2-like cytokine profile, but some deficiency in Th1- status discovered in patients with BC.

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Dmytryk, V., Luhovska, T., Yakovlev, P., Savchuk, O., Ostapchenko, L., Halenova, T., Raksha, N., Tomchuk, V., & Vovk, T. (2020). Elevated levels of proinflammatory and anti-inflammatory cytokines in patients with bladder cancer depending on a tumor stage. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 93(1). https://doi.org/10.4081/jbr.2020.8632