Antitumoral activity of curcumin: an adjuvant therapeutic strategy

  • Giovanni Tomasello | giovanni.tomasello@unipa.it Department of Biomedical Neuroscience and Advanced Diagnosis, Italy.
  • Marco Giammanco Department of Surgical Oncological and Oral Sciences, University of Palermo, Italy.
  • Margherita Mazzola Department of Biomedical Neuroscience and Advanced Diagnosis, Italy.
  • Provvidenza Damiani University Hospital “P. Giaccone”, Palermo, Italy.
  • William Ra’ School of Medicine and Surgery, University of Palermo, Italy.
  • Paola Giammanco School of Medicine and Surgery, University of Palermo, Italy.
  • Francesca Rappa Department of Biomedical Neuroscience and Advanced Diagnosis, Italy.
  • Alessandro Pitruzzella Department of Biomedical Neuroscience and Advanced Diagnosis, Italy.
  • Dario Saguto Department of Biomedical Neuroscience and Advanced Diagnosis, Italy.
  • Benedetto Di Trapani Department of General Surgery, Torina Hospital, Palermo, Italy.
  • Giovanni Taverna School of Medicine and Surgery, University of Palermo, Italy.
  • Mike Carini University of Milano, Italy.
  • Antonio Ciulla Department of General Surgery, Torina Hospital, Palermo, Italy.
  • Francesco Carini Department of Biomedical Neuroscience and Advanced Diagnosis, Italy.

Abstract

Curcumin, an active substance contained in an Indian spice called turmeric or curcuma, is well known for its anti-inflammatory and antioxidant properties. In recent times, it was taken into account and studied as an antitumoral molecule, by relying on its interference on several biological mechanisms, such as the inhibition of inflammatory mediators, the enhancement of detoxifying enzymes’ action and processes of cell growth and proliferation. Studies show how the high dosage of curcumin in vitro inhibits colorectal tumor cells, pancreatic tumor cells, lung cancer cells and glioblastoma’s cells, interfering in signaling pathways as Wnt/β-catenin, NF-kB and PI3K/Akt and leading to cell cycle arrest and apoptosis. Furthermore, the association between curcumin and chemotherapeutic agents such as 5-fluorouracil strengthens the drug’s cytotoxicity and cells’ susceptibility towards the chemotherapeutic agent.

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Published
2021-01-21
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Section
Review Articles
Keywords:
Curcumin, colon cancer, chemoprevention, antitumor activity, 5-fluorouracil, nutrition, glioblastoma, pancreatic cancer, stomach cancer, lung cancer, therapeutic adjuvant
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How to Cite
Tomasello, G., Giammanco, M., Mazzola, M., Damiani, P., Ra’, W., Giammanco, P., Rappa, F., Pitruzzella, A., Saguto, D., Di Trapani, B., Taverna, G., Carini, M., Ciulla, A., & Carini, F. (2021). Antitumoral activity of curcumin: an adjuvant therapeutic strategy. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 93(2). https://doi.org/10.4081/jbr.2020.8252