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Flutamide-induced hepatotoxicity: A case report

Vol. 95 No. 2 (2022)
Submitted: January 20, 2022
Accepted: May 12, 2022
Published: June 10, 2022
Flutamide, liver, prostate
Abstract Views: 1506
PDF: 206
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Authors

Omer M. Kassid
Department of Medicine, College of Medicine, University of Misan, Misan, Iraq.
Samih A. Odhaib
https://orcid.org/0000-0002-7212-4358
Adult Endocrinologist, Thi Qar Specialized Diabetes Endocrine and Metabolism Center (TDEMC), Thi Qar Health Directorate, Thi Qar, Iraq.
Mahmood Thamer Altemimi
mahmoodaltimimi83@gmail.com
Adult Endocrinologist, Thi Qar Specialized Diabetes Endocrine and Metabolism Center (TDEMC), Thi Qar Health Directorate, Thi Qar, Iraq.

Flutamide is a non-steroidal anti-androgen drug effective in the management of prostatic carcinoma. The drug appears to be well tolerated with mild gastrointestinal adverse events and gynecomastia. Flutamide-induced hepatotoxicity may range from minor elevation in liver enzymes to hepatic failure. Here, we tried to discuss the possibility of hepatotoxicity induced by flutamide as antiandrogen therapy in a patient with prostatic adenocarcinoma. Here we present a 75-year-old man who commenced flutamide as a postoperative anti-androgen for prostatic adenocarcinoma for two months. He had markedly elevated levels of liver enzymes due to acute liver failure and subsequent multi-organ failure. The patient died after the failure of the resuscitation measures. The temporal relationship between the flutamide initiation and the emergence of hepatotoxicity is not clear, with a possible latency of 12-16 weeks. Careful monitoring of liver function test during flutamide therapy is essential to prevent serious hepatotoxicity.

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How to Cite

Kassid, O. M., Odhaib, S. A., & Altemimi, M. T. . (2022). Flutamide-induced hepatotoxicity: A case report. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 95(2). https://doi.org/10.4081/jbr.2022.10371
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