https://doi.org/10.4081/gc.2023.11066

Prolonged liver transplantation survival and aging successfully

Vol. 9 No. 1 (2023)
Submitted: 5 December 2022
Accepted: 3 March 2023
Published: 8 May 2023
aging, liver transplantation, chronic disease, multimorbidity, successful aging
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Authors

Francesco Pollicino
https://orcid.org/0009-0005-4549-0490
Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Italy.
Ligia J. Dominguez
ligia.dominguez@unipa.it
Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo; Faculty of Medicine and Surgery, Kore University, Enna, Italy.
Mario Barbagallo
Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Italy.

The traditional definition of successful aging as the absence of disease, disability, and cognitive impairment is not always applicable to patients with long survival despite complex multimorbidity. This case report details the situation of an 87-year-old man, currently partially self-sufficient and partially autonomous, without cognitive impairment, who has been affected with recurrent right knee osteomyelitis since the age of 6. A diagnosis of hepatitis C virus (HCV)-related liver cirrhosis at 41 led to liver transplantation at 56. The immunosuppressive anti-rejection therapy caused a relapse of chronic osteomyelitis and HCV infection, a major cause of graft loss and shortened survival in HCV liver transplant recipients. Other pathologies were also diagnosed during his lifetime. This patient is an example of aging successfully despite complex multimorbidity and disproves the traditional concept of successful aging formerly described in the literature.

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Crossref
Scopus
Google Scholar
Europe PMC
Rowe JW, Kahn RL. Successful aging. Gerontologist 1997;37:433-40. DOI: https://doi.org/10.1093/geront/37.4.433
Kim SH, Park S. A meta-analysis of the correlates of successful aging in older adults. Res Aging 2017;39:657-77. DOI: https://doi.org/10.1177/0164027516656040
Vetrano DL, Palmer K, Marengoni A, et al. Frailty and multimorbidity: a systematic review and meta-analysis. J Gerontol A Biol Sci Med Sci 2019;74:659-66. DOI: https://doi.org/10.1093/gerona/gly110
Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56:M146-56. DOI: https://doi.org/10.1093/gerona/56.3.M146
Blokzijl F, de Ligt J, Jager M, et al. Tissue-specific mutation accumulation in human adult stem cells during life. Nature 2016;538:260-4. DOI: https://doi.org/10.1038/nature19768
Newman AB, Arnold AM, Sachs MC, et al. Long-term function in an older cohort-the cardiovascular health study all stars study. J Am Geriatr Soc 2009;57:432-40. DOI: https://doi.org/10.1111/j.1532-5415.2008.02152.x
Britton A, Shipley M, Singh-Manoux A, et al. Successful aging: the contribution of early-life and midlife risk factors. J Am Geriatr Soc 2008;56:1098-105. DOI: https://doi.org/10.1111/j.1532-5415.2008.01740.x
Costa D, Scognamiglio M, Fiorito C, et al. Genetic background, epigenetic factors and dietary interventions which influence human longevity. Biogerontology 2019;20:605-26. DOI: https://doi.org/10.1007/s10522-019-09824-3
Cole MG, Dendukuri N. Risk factors for depression among elderly community subjects: a systematic review and meta-analysis. Am J Psychiatry 2003;160:1147-56. DOI: https://doi.org/10.1176/appi.ajp.160.6.1147
Almeida OP, Norman P, Hankey G, et al. Successful mental health aging: results from a longitudinal study of older Australian men. Am J Geriatr Psychiatry 2006;14:27-35. DOI: https://doi.org/10.1097/01.JGP.0000192486.20308.42
Fayek SA, Quintini C, Chavin KD, Marsh CL. The current state of liver transplantation in the United States: a perspective from american society of transplant surgeons (ASTS) scientific studies committee and endorsed by ASTS council. Am J Transplant 2016;16:3093-104. DOI: https://doi.org/10.1111/ajt.14017
Young Y, Frick KD, Phelan EA. Can successful aging and chronic illness coexist in the same individual? A multidimensional concept of successful aging. J Am Med Dir Assoc 2009;10:87-92. DOI: https://doi.org/10.1016/j.jamda.2008.11.003
Schmitt SK. Osteomyelitis. Infect Dis Clin North Am 2017;31:325-38. DOI: https://doi.org/10.1016/j.idc.2017.01.010
Yang LS, Shan LL, Saxena A, Morris DL. Liver transplantation: a systematic review of long-term quality of life. Liver Int 2014;34:1298-313. DOI: https://doi.org/10.1111/liv.12553
Barrera Pulido L, Alamo Martínez JM, Pareja Ciuró F, et al. Efficacy and safety of mycophenolate mofetil monotherapy in liver transplant patients with renal failure induced by calcineurin inhibitors. Transplant Proc 2008;40:2985-7. DOI: https://doi.org/10.1016/j.transproceed.2008.09.017
Lucey MR, Terrault N, Ojo L, et al. Long-term management of the successful adult liver transplant: 2012 practice guideline by the american association for the study of liver diseases and the american society of transplantation. Liver Transpl 2013;19:3-26. DOI: https://doi.org/10.1002/lt.23566
Ojo AO, Held PJ, Port FK, et al. Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med 2003;349:931-40. DOI: https://doi.org/10.1056/NEJMoa021744
Ramos-Prol A, Hervás-Marín D, García-Castell A, Merino-Torres JF. Outcomes in patients with diabetes 10 years after liver transplantation. J Diabetes 2017;9:1033-9. DOI: https://doi.org/10.1111/1753-0407.12520
Morley JE. Aging successfully: the key to aging in place. J Am Med Dir Assoc 2015;16:1005-7. DOI: https://doi.org/10.1016/j.jamda.2015.09.011
Kivimäki M, Ferrie JE. Epidemiology of healthy aging and the idea of more refined outcome measures. Int J Epidemiol 2011;40:845-7. DOI: https://doi.org/10.1093/ije/dyr114

How to Cite

Pollicino, F., Dominguez, L. J., & Barbagallo, M. (2023). Prolonged liver transplantation survival and aging successfully. Geriatric Care, 9(1). https://doi.org/10.4081/gc.2023.11066
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