https://doi.org/10.4081/gc.2023.11021

Association between nutritional status and cognitive decline in non-institutionalized elderly patients evaluated in a geriatric outpatient setting

Vol. 9 No. 1 (2023)
Submitted: 7 December 2022
Accepted: 6 April 2023
Published: 8 May 2023
dementia, malnutrition, frailty, aged, cognitive decline, disability
Abstract Views: 1486
PDF: 313
HTML: 47
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Raffaele Pagliuca
rafpag2010@hotmail.it
Department of Geriatric Medicine, A.O.R.N. Caserta; Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.
Stefano Cacciatore
https://orcid.org/0000-0001-7504-3775
Department of Geriatrics and Orthopedics, Università Cattolica del Sacro Cuore, Rome, University Policlinic Foundation Agostino Gemelli, Rome, Italy.
Mario Virgilio Papa
https://orcid.org/0000-0002-1579-2202
Department of Medical and Surgical Sciences, University of Padua, Italy.
Eugenio Boccalone
https://orcid.org/0000-0003-1113-0196
ASL, Benevento, Italy.
Mena Ilaria Pagliuca
Department of Pharmacology University of Naples Federico II, Naples, Italy.
Federica Virginia Papa
https://orcid.org/0000-0003-4931-525X
Local health authority (ASL), Caserta, Italy.
Antonio Gambardella
https://orcid.org/0000-0002-4125-0618
Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.

This study aims to assess the relationship between nutritional status and cognitive decline in a population of non-institutionalized elderly patients evaluated in a geriatric outpatient setting. Data from 144 patients admitted to the general geriatric outpatient services of Luigi Vanvitelli University Hospital (Naples, Italy) and San Felice a Cancello Hospital (San Felice a Cancello, Italy) were collected between January 1 and December 31, 2017. Cognitive function was evaluated through the mini-mental state examination and nutritional status was assessed through mini nutritional assessment. Logistic regression was used to assess the association between clinical characteristics and nutritional status, and it is reported as unadjusted, adjusted for age and sex, and adjusted for other potential confounding factors. In the unadjusted model, poor nutritional status was associated with a worse cognitive deficit (odds ratio (OR)=2.36; 95% confidence interval (CI)=1.77-3.55). The association remained significant after adjusting for age and sex (OR=2.36; 95% CI=1.77-3.55) and in the fully adjusted model (OR=2.92; 95% CI=1.90-5.64). In patients with dementia, malnutrition represents a significant burden that grows heavier as the disease progresses.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Landi F, Picca A, Calvani R, Marzetti E. Anorexia of aging: assessment and management. Clin Geriatr Med 2017;33:315-23. DOI: https://doi.org/10.1016/j.cger.2017.02.004
Sulo S, Vargas J, Gomez G, et al. Hospital nutrition care informs potential cost-savings for healthcare: a budget impact analysis. Clin Nutr ESPEN 2021;42:195-200. DOI: https://doi.org/10.1016/j.clnesp.2021.01.041
Ishida Y, Maeda K, Nonogaki T, et al. Malnutrition at admission predicts in-hospital falls in hospitalized older adults. Nutrients 2020;12:541. DOI: https://doi.org/10.3390/nu12020541
Donini LM, De Bernardini L, De Felice MR, et al. Effect of nutritional status on clinical outcome in a population of geriatric rehabilitation patients. Aging Clin Exp Res 2004;16:132-8. DOI: https://doi.org/10.1007/BF03324542
Landi F, Camprubi-Robles M, Bear DE, et al. Muscle loss: the new malnutrition challenge in clinical practice. Clin Nutr 2019;38:2113-20. DOI: https://doi.org/10.1016/j.clnu.2018.11.021
Yu Z, Kong D, Peng J, et al. Association of malnutrition with all-cause mortality in the elderly population: a 6-year cohort study. Nutr Metab Cardiovasc Dis 2021;31:52-9. DOI: https://doi.org/10.1016/j.numecd.2020.08.004
Uhl S, Siddique SM, Bloschichak A, et al. Interventions for malnutrition in hospitalized adults: a systematic review and meta-analysis. J Hosp Med 2022;17:556-64. DOI: https://doi.org/10.1002/jhm.12891
Bellanti F, Lo Buglio A, Quiete S, Vendemiale G. Malnutrition in hospitalized old patients: screening and diagnosis, clinical outcomes, and management. Nutrients 2022;14:910. DOI: https://doi.org/10.3390/nu14040910
Norman K, Haß U, Pirlich M. Malnutrition in older adults-recent advances and remaining challenges. Nutrients 2021;13:2764. DOI: https://doi.org/10.3390/nu13082764
O'Keeffe M, Kelly M, O'Herlihy E, et al. Potentially modifiable determinants of malnutrition in older adults: a systematic review. Clin Nutr 2019;38:2477-98. DOI: https://doi.org/10.1016/j.clnu.2018.12.007
Corish CA, Bardon LA. Malnutrition in older adults: screening and determinants. Proc Nutr Soc 2019;78:372-9. DOI: https://doi.org/10.1017/S0029665118002628
Besora-Moreno M, Llauradó E, Tarro L, Solà R. Social and economic factors and malnutrition or the risk of malnutrition in the elderly: a systematic review and meta-analysis of observational studies. Nutrients 2020;12:737. DOI: https://doi.org/10.3390/nu12030737
Folstein MF, Folstein SE, McHugh PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98. DOI: https://doi.org/10.1016/0022-3956(75)90026-6
Measso G, Cavarzeran F, Zappalà G, et al. The mini-mental state examination: normative study of an italian random sample. Dev Neuropsychol 1993;9:77-85. DOI: https://doi.org/10.1080/87565649109540545
Carpinelli Mazzi M, Iavarone A, Russo G, et al. Mini-mental state examination: new normative values on subjects in southern Italy. Aging Clin Exp Res 2020;32:699-702. DOI: https://doi.org/10.1007/s40520-019-01250-2
Vellas B, Guigoz Y, Garry PJ, et al. The mini nutritional assessment (MNA) and its use in grading the nutritional state of elderly patients. Nutrition 1999;15:116-22. DOI: https://doi.org/10.1016/S0899-9007(98)00171-3
Sheikh JI, Yesavage JA. Geriatric depression scale (GDS): recent evidence and development of a shorter version. Clin Gerontologist 1986;5:165-73. DOI: https://doi.org/10.1300/J018v05n01_09
Coelho-Júnior HJ, Trichopoulou A, Panza F. Cross-sectional and longitudinal associations between adherence to Mediterranean diet with physical performance and cognitive function in older adults: a systematic review and meta-analysis. Ageing Res Rev 2021;70:101395. DOI: https://doi.org/10.1016/j.arr.2021.101395
Jang JW, Kim Y, Choi YH, et al. Association of nutritional status with cognitive stage in the elderly Korean population: the Korean brain aging study for the early diagnosis and prediction of Alzheimer's disease. J Clin Neurol 2019;15:292-300. DOI: https://doi.org/10.3988/jcn.2019.15.3.292
Kimura A, Sugimoto T, Kitamori K, et al. Malnutrition is associated with behavioral and psychiatric symptoms of dementia in older women with mild cognitive impairment and early-stage Alzheimer's disease. Nutrients 2019;11:1951. DOI: https://doi.org/10.3390/nu11081951
Borda MG, Ayala Copete AM, Tovar-Rios DA, et al. Association of malnutrition with functional and cognitive trajectories in people living with dementia: a five-year follow-up study. J Alzheimers Dis 2021;79:1713-22. DOI: https://doi.org/10.3233/JAD-200961
Sanders CL, Wengreen HJ, Schwartz S, et al. Nutritional status is associated with severe dementia and mortality: the cache county dementia progression study. Alzheimer Dis Assoc Disord 2018;32:298-304. DOI: https://doi.org/10.1097/WAD.0000000000000274
Coelho-Júnior HJ, Calvani R, Landi F, et al. Protein intake and cognitive function in older adults: a systematic review and meta-analysis. Nutr Metab Insights 2021;14:11786388211022373. DOI: https://doi.org/10.1177/11786388211022373
Volkert D, Chourdakis M, Faxen-Irving G, et al. ESPEN guidelines on nutrition in dementia. Clin Nutr 2015;34:1052-73. DOI: https://doi.org/10.1016/j.clnu.2015.09.004
Marshall KA, Burson R, Gall K, Saunders MM. Hospital admissions for malnutrition and dehydration in patients with dementia. Home Healthc Now 2016;34:32-7. DOI: https://doi.org/10.1097/NHH.0000000000000327
Fostinelli S, De Amicis R, Leone A, et al. Eating behavior in aging and dementia: the need for a comprehensive assessment. Front Nutr 2020;7:604488. DOI: https://doi.org/10.3389/fnut.2020.604488
Hum A, Tay RY, Wong YKY, et al. Advanced dementia: an integrated homecare programme. BMJ Support Palliat Care 2020;10:e40. DOI: https://doi.org/10.1136/bmjspcare-2019-001798
Soysal P, Dokuzlar O, Erken N, et al. The relationship between dementia subtypes and nutritional parameters in older adults. J Am Med Dir Assoc 2020;21:1430-5. DOI: https://doi.org/10.1016/j.jamda.2020.06.051
Volkert D, Beck AM, Cederholm T, et al. ESPEN guideline on clinical nutrition and hydration in geriatrics. Clin Nutr 2019;38:10-47 DOI: https://doi.org/10.1016/j.clnu.2018.05.024

How to Cite

Pagliuca, R., Cacciatore, S., Papa, M. V., Boccalone, E., Pagliuca, M. I., Papa, F. V., & Gambardella, A. (2023). Association between nutritional status and cognitive decline in non-institutionalized elderly patients evaluated in a geriatric outpatient setting. Geriatric Care, 9(1). https://doi.org/10.4081/gc.2023.11021
Copyright (c) 2023 the Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.


Similar Articles

You may also start an advanced similarity search for this article.