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Role of interleukin-4 and their antagonistic effect in asthma

Authors

Muhammad Usman Ali Khan
usman.a.khan415@gmail.com
Department of Pharmacology University of Health Sciences Lahore, Pakistan.
Tasleem Akhtar
CIMS, Multan, Pakistan.
Muhammad Yasoob Ali Khan
Department of Hematology University of Health Sciences Lahore, Pakistan.
Muhammad Asif Faheem
Department of Pharmacology University of Health Sciences Lahore, Pakistan.
Zari Salahuddin
Department of Pharmacology University of Health Sciences Lahore, Pakistan.
Nasir Muhammad
Department of Hematology University of Health Sciences Lahore, Pakistan.

Asthma is a chronic inflammatory disease of the lower airways, characterize by wheezing cough, chest tightness along with inflammation of airway and shortness of breath. Allergens like environmental substance are predispose asthmatics patients to allergy. Mast cells produced interleukin (IL)- 4 which either activate signal transducer and activator of transcription 6 (STAT-6) pathway that involved in differentiation of na ve T-cells to TH2 or activation of TH2 cells indirectly. The aim of the current context is to present role of IL-4 in asthma and effect as antagonist. IL-4 results in increased mucus production and involve in IgE synthesis from B cells. IL4 facilitate chemotaxis and aid in displaying of VCAM-1 which attract eosinophil basophils monocytes T-lymphocytes to blood vessel. IL4 inhibit apoptosis either by preventing decrease in BCL-2 level or binding of FasL to Fas (cd32) receptor which result in acute allergic response. Elevated level of IL-4 has greatly adverse impact on asthmatic patients so by decreasing the level of IL-4 will greatly reduce asthma phenotype.

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How to Cite

Khan, M. U. A., Akhtar, T., Khan, M. Y. A., Faheem, M. A., Salahuddin, Z. ., & Muhammad, N. (2022). Role of interleukin-4 and their antagonistic effect in asthma. Geriatric Care, 8(1). https://doi.org/10.4081/gc.2022.10150

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