TY - JOUR AU - Lin, Lijun AU - Ma, Siqing AU - Yao, Yongli AU - Luo, Junming AU - Shi, Qingjun AU - Chen, Qiang PY - 2018/09/11 Y2 - 2024/03/28 TI - Study on improvement of recruitment maneuvers and extravascular lung water in oxygenation of high altitude acute respiratory distress syndrome JF - Chest Disease Reports JA - Chest Dis Rep VL - 8 IS - 1 SE - Original Articles DO - 10.4081/cdr.8.7028 UR - https://www.pagepressjournals.org/chest/article/view/7028 SP - AB - <p>To understand the improvement of recruitment maneuvers and extravascular lung water in oxygenation of high altitude acute respiratory distress syndrome, 30 HARDS patients were enrolled&nbsp;in the study from May 2012 to October 2013 from Qinghai Provincial People’s&nbsp;Hospital.&nbsp;All the patients received recruitment maneuvers and Pulse Contour Cardiac Output, hemodynamics monitoring including intrathoracic Blood Volume Index; Global End-diastolic Volume Index; Global ejection fraction; Pulmonary Vascular Permeability Index; Extravascular Lung Water Index; Pulse indicates cardiac Index; Stroke Volume Variation; Pulse pressure variation; Maximum pressure to increase speed; Systemic Venous Resistance Index, oxygenation and hemodynamics were determined before and after 72 hours of recruitment maneuvers.&nbsp;The results showed that after treatment with recruitment maneuvers&nbsp;and capacity limitation, PaO<sub>2</sub>/FiO<sub>2</sub>&nbsp;was increased significantly compared with those before treatment [PaO<sub>2</sub>/FiO<sub>2</sub> (mmHg): 124.70±43.37 <em>vs</em> 186.87±41.20, <em>t</em>=9.43, P&lt;0.001], ITBVI, GEDVI, PVPI, EVLWI, SVV were reduced significantly compared with those before treatment[ITBVI (ml/m<sup>2</sup>): 1031.00±275.88 <em>vs</em> 907.13±242.56, t=1.26, P=0.041; GEDVI (ml/m<sup>2</sup>): 822.40±143.30 <em>vs</em> 722.83±169.65, t=1.75, P=0.016; PVPI (ml/kg): 2.71±1.21 <em>vs</em> 1.98±0.65, t=2.86, P=0.001; EVLWI (ml/kg): 12.30±4.19 <em>vs</em> 8.12±2.94, t=8.27, P&lt;0.001; SVV (%):17.30±5.65 <em>vs</em> 10.33±3.47, t=9.17, P&lt;0.001]. Our results indicated that recruitment maneuvers and capacity limitation have been improved oxygenation in HARDS, extravascular lung water reduced, and lung capillary permeability also improved.</p> ER -