A therapeutic genome editing primer for cardiologists

  • Martina Caiazza | martina.caiazza@yahoo.it Department of Cardiology, Università Degli Studi Della Campania, Luigi Vanvitelli, Naples, Italy.
  • Daniele Masarone Department of Cardiology, Università Degli Studi Della Campania, Luigi Vanvitelli, Naples, Italy.
  • Giuseppe Limongelli Department of Cardiology, Università Degli Studi Della Campania, Luigi Vanvitelli, Naples, Italy.

Abstract

Genome editing, or genome engineering is a type of genetic engineering in which DNA is inserted, deleted or replaced in the genome of a living organism using engineered nucleases, or molecular scissors. Genome editing is being rapidly adopted into all fields of biomedical research, including the cardiovascular field, where it has facilitated a greater understanding of lipid metabolism, electrophysiology, cardiomyopathies, and other cardiovascular disorders, has helped to create a wider variety of cellular and animal models, and has opened the door to a new class of therapies. In this review, we discuss the applications of in vivo genome-editing therapies for cardiovascular disorder.

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Published
2018-05-16
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Section
Review Articles
Keywords:
Therapeutic genome editing, cardiovascular disease.
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  • PDF: 246
How to Cite
Caiazza, M., Masarone, D., & Limongelli, G. (2018). A therapeutic genome editing primer for cardiologists. Cardiogenetics, 8(1). https://doi.org/10.4081/cardiogenetics.2018.7262