FOR AUTHORS
Vol. 36 No. s2 (2026): 22nd Meeting of the Interuniversity Institute of Myology, Assisi, Italy, 11-14 September 2025
Published:
07-04-2026
Abstracts of the 22nd Meeting of the Interuniversity Institute of Myology
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01 | Investigating skeletal muscle-endothelial cell crosstalk in plasticity and disease José Fernández-Martínez1|2, A. Gensel1|2, E. Germinario2, R.E. Oberkersch3, M.M. Santoro3, B. Blaauw1|2 | 1Veneto Institute of Molecular Medicine, Padua, Italy; 2Department of Biomedical Sciences, University of Padua, Italy; 3Department of Biology, University of Padua, Italy. | José Fernández-Martínez and A. Gensel contributed equally to this work.
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02 | Entrainment of skeletal muscle circaldian clock by 2-hydroxybutyrate, a noval exerkine Taoyue Yang1|2, L. Matta1, A. Bartelt1|3, K. Dyar1 | 1Institute for Diabetes and Cancer, Helmholtz Munich, Germany; 2Faculty of Medicine, Ludwig-Maximilian-Universität München, Germany; 3Traslational Nutritional Medicine, Technical University of Munich, Germany.
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03 | The muscle out of breath? Limitations and adaptations in chronic diseases Angèle N. Merlet1|2, L.A Messonnier3|4, L. Féasson1|2 | 1Unité de Myologie, Service de Physiologie Clinique et de l'Exercice, Centre Référent Maladies Neuromusculaires Rares – Euro-NmD, Hôpital Universitaire de Saint-Etienne, Saint-Etienne, France; 2Laboratoire Interuniversitaire de Biologie de la Motricité, EA 7424, F-42023, Université de Lyon, UJM-Saint- Etienne, France; 3Univ. Savoie Mont Blanc, Laboratoire Interuniversitaire de Biologie de la Motricité, Chambéry, France; 4Institut Universitaire de France (IUF).
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04 | CD90 identifies distinct fractions of muscle stem cells with different modalities of activation and quiescence maintenance Lorenzo Marramiero1|2, S. Di Savino1|2, E. Kheir1|2, M. Libergoli1|2, S. Metti3, A. Zola1|2, J.B. Jensen4|5, J.Wang5, N. Jessen4|5|6, F. Florio1|2, F. Murganti1|2, M. Belicchi 7|8, C. Villa8, K. Vissing9, M. Verma10, L. Giordani11, P. Bonaldo3, Y. Torrente7|8, J. Farup4, S. Biressi1|2 | 1Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Povo, Italy; 2Dulbecco Telethon Institute at University of Trento, Povo, Italy; 3Department of Molecular Medicine, University of Padova, Italy; 4Department of Biomedicine, Aarhus University, Denmark; 5Steno Dia,5betes Center Aarhus, Denmark; 6Department of Clinical Pharmacology, Aarhus University Hospital, Denmark; 7Neurology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; 8Stem Cell Laboratory, Dino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, Italy; 9Department of Public Health, Aarhus University, Denmark; 10University of Texas Southwestern Medical Center, Dallas, USA; 11Centre de Recherche en Myologie, Sorbonne Universités,Paris, France.
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06 | Pharmacological AMPK activation promotes higher levels of Pax7 expression in human muscle stem cells D. Michel1, A. Bouche1|2, R. Mounier3, D. Hannouche1|2, Thomas Laumonier1|2 | 1Cell Therapy and Musculoskeletal Disorders Laboratory, Department of Orthopedic Surgery, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland; 2Department of Cell Physiology and Metabolism, Faculty of Medicine, Geneva, Switzerland; 3Institut Neuromyogène, CNRS 5261 – INSERM U1315 - UCBL1, Lyon, France.
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07 | Role of GDF5 on macrophage polarization in the maintenance of muscle mass and function and during aging Maxime Gelin1, E. Hemery1, F. Truffault1, G. Juban2, C. Perrotta3, F. Pietri-Rouxel1, M. Traoré1, S. Falcone1 | 1Centre de Recherche en Myologie – U974 INSERM, Sorbonne Université, Institut de Myologie, Paris, France; 2Institut NeuroMyoGène, Physiopathologie et Génétique du Neurone et du Muscle Université Claude Bernard Lyon 1, CNRS U5261, Inserm U1315, University Lyon, Lyon, France; 3Department of Biomedical and Clinical Sciences Università degli Studi di Milano, Milan, Italy. | M. Traoré and S. Falcone contributed equally to this work and corresponding authors. s.falcone@institut-myologie.org; m.traore@institut-myologie.org.
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08 | Combination therapy targeting HDAC8 and SIRT1 improves muscle integrity in a Duchenne muscular dystrophy zebrafish model Sabrina Carbone1, A. Brix1, L. Lociuro1, O. Gjana1, L. Belleri2, M. Schiavone3, A. Marozzi1, F. Del Bene2, C. De Palma1, A. Pezzotta1, A. Pistocchi1 | 1Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy; 2Sorbonne Université, INSERM U968, CNRS UMR 7210, Institut de la Vision, Paris, France; 3Department of Molecular and translational medicine, Università degli Studi di Brescia, Brescia, Italy.
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09 | Identification of CaVβ1 isoforms required for neuromuscular junction formation and maintenance A. Vergnol1, A. Bourguiba1, S. Bauché1, M. Traoré1, M. Gelin1, C. Gentil1, S. Pezet1, L. Saillard1, P. Meunier1, M. Lemaitre2, J. Perronnet2, F. Tores3, C. Gautier4, Z. Guesmia1, E. Allemand4, E. Batsché5, F. Pietri-Rouxel1, Sestina Falcone1 | 1Centre de Recherche en Myologie – U974 INSERM, Sorbonne Université, Institut de Myologie, Paris, France; 2Phénotypage du petit animal – UM28 INSERM, Sorbonne Université, Paris, France; 3Institut Imagine – BIP-D Plateforme de Bioinformatique, Université Paris Cité, Paris, France; 4Institut Imagine – U1163 INSERM, Université Paris Cité, Paris, France; 5Institut de Biologie Paris-Seine (IBPS)– UMR 7238 CNRS, Sorbonne Université, Paris, France. | Corresponding authors are F. Pietri-Rouxel and S. Falcone; A. Bourguiba, S. Bauché, F. Pietri-Rouxel and S. Falcone contributed equally to this work.
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10 | Human myogenic progenitor and 3D bioprinting for volumetric muscle loss recovery in swine model Rebecca Deodati, F. De Paolis, E. Guarnaccia, B. Corci, S. Bernardini, M. Costantini, C. Fuoco, C. Gargioli | Dept. of Biology, University of Tor Vergata, Rome, Italy.
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11 | Human immortalized myoblasts/induced pluripotent stem cell derived skeletal muscle model to investigate cystinosis myopathy Jianhao Zhang1, R. Mora De La Serna2, M. Smits2, V. Marini1, A. Wang1, M. Biglietto1, M. Campaner Socias1, L. Rinvenuto1, Z. Ge1, R. Gijsbers2|3, M. Sampaolesi1|4 | 1Translational Cardiomyology Laboratory, Stem Cell and Developmental Biology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; 2Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium; 3Leuven Viral Vector Core, KU Leuven, Leuven, Belgium; 4Histology and Medical Embryology Unit, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Rome, Italy.
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12 | In vitro study emulating muscle response to stimuli exploiting 3D tissue model Elena Guarnaccia, R. Deodati, F. De Paolis, B. Corci, S. Bernardini, C. Fuoco, C. Gargioli | Dept. of Biology, University of Tor Vergata, Rome, Italy.
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13 | Generation of human stem cell-derived cardiac in vitro models to investigate the role of epicardial activation in adverse cardiac remodeling Margalida Campaner Socias1, V. Marini1, L. Rinvenuto1, A. Wang1, J. Zhang1, S. Morri1, D. Stalkopf1, R. Oida1, B. Sampaio1, M. Sampaolesi1|2 | 1Laboratory of Translational Cardiomyology, Stem Cell and Developmental Biology Unit, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; 2Histology and Medical Embryology Unit, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, Rome, Italy.
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14 | Extracellular matrix guides human neuromuscular organoid morphogenesis Beatrice Auletta1|2|3, P. Chiolerio1|2, G. Cecconi1|2, L. Sartore1|2, L. Rossi1|2, E. Maghin4, S. Angiolillo3|5, S. Calabrò1, O. Gagliano3|5, C. Laterza3|5, M. Cescon1, Y. Torrente6|7, C. Luni8, M. Piccoli4, N. Elvassore3|5, A. Urciuolo1|2 | 1Department of Molecular Medicine, University of Padova, Padova, Italy; 2Neuromuscular Engineering lab, Istituto di Ricerca Pediatrica, Città della Speranza, Padova, Italy; 3Department of Industrial Engineering, University of Padova, Padova, Italy; 4Tissue Engineering lab, Istituto di Ricerca Pediatrica, Città della Speranza, Padova, Italy; 5Veneto Institute of Molecular Medicine, Padova, Italy; 6Stem Cell Laboratory, Dino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; 7Neurology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; 8Department of Civil, Chemical, Environmental and Materials Engineering (DICAM), University of Bologna, Italy.
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15 | GDF5 therapeutic potential for Duchenne muscular dystrophy C. Gentil, A. Bourguiba, A. Vergnol, B. Cadot, Z. Guesmia, L. Saillard, P. Meunier, S. Falcone, L. Giordani, France Pietri-Rouxel | Sorbonne Université, INSERM, Institut de Myologie, Centre de Recherche en Myologie, Paris, France.
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16 | Immunoproteasome inhibition positively impacts the gut-muscle axis in Duchenne muscular dystrophy Debora Mostosi1, A. Farini2, F. Strati3, M. Molinaro2, S. Saccone2, C. Amoroso3, B. Cassani4, E. Leonetti1, F. Caprioli5, F. Facciotti3, Y. Torrente1|2 | 1Stem Cell Laboratory, Dino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; 2Neurology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; 3Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy; 4Department of Medical Biotechnologies and Translational Medicine, University of Milan, Italy; 5Department of Pathophysiology and Transplantation, University of Milan, Unit of Gastroenterology and Endoscopy, Fondazione IRCCS Ca’ Granda, Ospedale Policlinico di Milano, Italy.
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18 | Double-edge sword of ketogenic diet: hepatic improvement at the expense of musculoskeletal health Alessandro Antonioli1, T. Raiteri2, A. Provera1, S. Reano3, S. Tini1, S. Sutti1, N. Filigheddu3, F. Prodam1 | 1Department of Health Sciences, University of Piemonte Orientale, Novara, Italy; 2Department of Medicine and Surgery, University of Perugia, Perugia, Italy; 3Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
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19 | Cachexia displays a unique pattern of gait alterations indicating a neurodegenerative condition Gaelle Revet1, K. Jangwa-Etame1, P. Joanne1, A. Diko1, M. Mangone2, A. Molfino2, Z. Li1, O. Agbulut1, D. Coletti2 | 1Sorbonne University, Paris, France; 2Sapienza University of Rome, Rome, Italy.
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20 | Exercise preserves purkinje cells' integrity from paraneoplastic cerebellar degeneration in a mouse model of cachexia Francesco Paolo Zummo, V. Sagagandomabadi, R. Barone, F. Macaluso, D. D'Amico, M. Sausa, F. Carini, V. Di Felice, S. David | Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy.
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21 | Transcriptional and metabolic analyses of cardiac mononucleated cells in dystrophic mdx mice upon treatment with a specific monoamino oxidase B inhibitor Francesca Fontana1|2, F.C. Venegas3|4, E. Baldisseri3|4, R. Sánchez-Rodríguez3|4, A. Reggio5, A. Palma6, M. Canton3|4, L. Vitiello1 | 1Department of Biology, University of Padova, Italy; 2Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Italy; 3Fondazione Istituto di Ricerca Pediatrica Città della Speranza, IRP, Italy; 4Department of Biomedical Sciences, University of Padova, Italy; 5Saint Camillus International University of Health Sciences, Italy; 6Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Italy.
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22 | Subcutaneous injection of microencapsulated Sertoli cells is more efficacious than deflazacort treatment in mdx mice Sara Chiappalupi1|2, G. Gentili1|2, L. Salvadori2|3, I. Arato1, F. Mancuso1, M. Paiella1|2, F. Riuzzi1|2, R. Calafiore1, G. Luca1, G. Sorci1|2 | 1Department of Medicine and Surgery, University of Perugia, Italy; 2Interuniversity Institute of Myology (IIM), Perugia, Italy; 3Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy. | S. Chiappalupi and G. Sorci shared Senior authorship; S. Chiappalupi and G. Gentili contributed equally.
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23 | Preclinical evaluation of 3s-HMGB1 as a therapeutic strategy for Duchenne muscular dystrophy Federica Esposito1, E. Sbolli1, S. Curtarello1, E. Ruggieri1|2, M. Patrone1|2, M. Rodrigues3, V. Taglietti3, F. Relaix3, E. Vénéreau1|2 | 1Unit, Division of Genetics and Cellular Biology, IRCCS Ospedale San Raffaele, Milan, Italy; 2University Vita-Salute San Raffaele, Milan, Italy; 3Univ Paris-Est Créteil, INSERM, U955 IMRB, Créteil, France.
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24 | Smooth muscle cells from human vagina express functional transient receptor potential channels Francesco Palmieri1, R. Garella1, I. Cellai2, G. Guarnieri1, E. Maseroli2, S. Cipirani2, M. Annunziato2, P. Comeglio2, A. Morelli1, M. Maggi2, L. Vignozzi2, R. Squecco1 | 1Dip. di Medicina Sperimentale e Clinica, Università di Firenze, Italy; 2Dip. di Scienze Biomediche Sperimentali e Cliniche, Università di Firenze, Italy.
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25 | Target adipogenic progenitors to cure Duchenne muscular dystrophy Luca Sali1, B. Periou2, A. Cojocaru1, E. Giry1, G. Severa2, L. Giordani3, V. Taglietti1, E. Malfatti1|2 | 1Univ. Paris-Est Créteil, INSERM, U955 IMRB, Créteil, France; 2Assistance Publique-Hôpitaux de Paris, Centre de Référence de Pathologie Neuromusculaire Nord-Est-Ile-de-France, Filnemus, Hôpital Henri Mondor, Créteil, France; European Reference Center for Neuromuscular Disorders, EURO-NMD, France; 3Sorbonne Université, INSERM UMRS 974, Association Institut de Myologie, Centre de Recherche en Myologie, Paris, France.
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26 | Validation of a new multi-target antioxidant treatment for the therapy of Duchenne muscular dystrophy F. Fontana1|2, F. Carozzi1, G. Piccoli3, L. Nogara3, G. Romagnoli2, E. Petricci2, B. Blaauw3, M. Canton3, Libero Vitiello1, F. Galvagni2 | 1Dept. of Biology, Univ. of Padova, Italy; 2Dept. of Biotechnology, Chemistry and Pharmacy, Univ. of Siena, Italy; 3Dept. of Biomedical Sciences, Univ. of Padova, Italy.
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27 | Polymeric nanoparticles as a favorable delivery system to enhance the anti-inflammatory action of n-palmitoylethanolamide, an endocannabinoid-like molecule E. Maretti1, C. Rustichelli1, B. Recchia1, G. Battaglia, E. de Nicola1, C. Fuoco2, A. Votta3, C. Gargioli2, E. Ferraro3, E. Leo1, Susanna Molinari1 | 1Dept. of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy; 2Dept. Of Biology, Tor Vergata Rome University, Rome, Italy; 3Dept. of Biology, University of Pisa, Pisa, Italy.
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28 | Impairment of skeletal muscle force and mitochondrial respiratory capacity precedes muscle mass loss in an aged murine model of diet-induced obesity Clara Sciorati1, R. De Lorenzo1|2, A. Avola1, M. Giovarelli3, C. De Palma3, E. Clementi3, C. Lanzani1, P. Rovere-Querini1|2 | 1IRCCS San Raffaele Hospital Scientific Institute, Milan, Italy; 2Vita-Salute San Raffaele University, Milan, Italy; 3Department of Biomedical and Clinical Science, University of Milan, Italy.
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29 | RNA-based combinatorial multi-target therapy for the treatment of Duchenne muscular dystrophy Mathieu Horeau, C. Pezzini, M. Sandri | Department of Biomedical Sciences, University of Padova, Italy.
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30 | The advanced glycation end-products (ages)/rage axis drives sarcobesity, which is restrained by Vaccinium macrocarpon extract Martina Paiella1|2, L. Salvadori2|3, T. Raiteri1|2, G. Gentili1|2, S. Chiappalupi1|2, T. Manenti4, G. Sorci1|2, F. Prodam5, N. Filigheddu2|3, F. Riuzzi1|2 | 1Dept. Medicine and Surgery, Univ. Perugia, Perugia, Italy; 2Interuniversity Institute of Myology (IIM), Perugia, Italy; 3Dept. Translational Medicine, Univ. Piemonte Orientale, Novara, Italy; 4Laboratori Biokyma srl, Anghiari, Italy; 5Dept. Health Science, Univ. Piemonte Orientale, Novara, Italy.
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31 | Exon skipping peptide-conjugated morpholinos downregulate dynamin 2 to rescue centronuclear myopathy Foteini Moschovaki-Filippidou1, J. de Carvalho Neves1, N. Diedhiou1, Y. Jad2|3, J. Böhm1, M.J.A. Wood2|3, M.A. Varela2|3, J. Laporte1 | 1IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, Illkirch, France; 2Department of Paediatrics, Institute of Developmental and Regenerative Medicine (IDRM), University of Oxford, UK; 3MDUK Oxford Neuromuscular Centre, Oxford, UK.
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32 | Trifolium pratense extract mitigates skeletal muscle atrophy: a nutraceutical approach for the prevention of sarcopenia Tommaso Raiteri1, H. Meskine2, M. Paiella1, A. Trabalzini1, I. Varfaj4, L. Salvadori2, F. Riuzzi1, R. Sardella4, F. Orlandi3, N. Filigheddu2, G. Sorci1 | 1Department of Medicine and Surgery, University of Perugia, Italy; 2Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy; 3Department of Civil and Environmental Engineering, University of Perugia, Italy; 4Department of Pharmaceutical Sciences, University of Perugia, Italy.
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33 | Identification of mTORC1-dependent muscle-specific factors involved in neuromuscular junction maintenance Paula Aranda-Martínez1, M. Baraldo2, S. Zorzato1, H. Nolte3, B. Blaauw1 | 1Department of Biomedical Sciences, Padua Univ., Italy; 2Biozentrum, Basel Univ., Basel; 3Max Planck Institute for Biology of Ageing, Cologne.
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34 | Hyaluronan enhances proliferation and myogenic differentiation of C2C12 murine myoblasts under inflammatory stress Fabio Ferrini, G. Annibalini, M. Battistelli, F. Fanelli, S. Moosavi, R. Osman, I. Capparucci, P. Sestili, E. Barbieri | Dept. of biomolecular sciences, University of Urbino, Italy.
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35 | A novel 3D skeletal muscle model to study cancer cachexia R. Wüst1, L. Terrie1, A. Weisrock1|2, L. Thorrez1, Emanuele Berardi1 | 1Tissue Engineering Lab, Department of Development and Regeneration, KU Leuven Kulak, Kortrijk, Belgium; 2Univ. Lille, CNRS, Centrale Lille, UMR 9013, LaMcube, Lille, France.
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36 | The effects of heat stress and exercise on skeletal muscle Chiara Malerba1, A. Laurino1, M. Serano, C. Pranzo1, F. Fiore1, E. Pierantozzi1, D. Rossi1|2, V. Sorrentino1|2 | 1Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy; 2Azienda Ospedaliero Universitaria Senese, Siena, Italy.
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37 | Characterization of novel cancer cachexia preclinical models implementing chemotherapy and surgery Emma Elisabeth Cappellato, C. Fornelli, N.E. Cortez, V. Schiavo, P. Costelli, F. Penna | Department of Clinical and Biological Sciences, University of Torino, Italy.
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38 | Effects of chronic treatment with conjugated linoleic acid on antioxidant gene expression and oxidative stress in SOD1-G93A mouse model of amyotrophic lateral sclerosis Letizia Claudione1, B. Boccanegra1, P. Mantuano1, F. Bacchetti2, M. Milanese2, P. Bergamo3, A. De Luca1, S. Pierno1 | 1Section of Pharmacology, Dept. of Pharmacy and Drug Sciences, University of Bari Aldo Moro, Bari, Italy; 2Dept. of Pharmacy, University of Genova, Genova, Italy; 3Institute of Biosciences and Bio-Resources, CNR, Napoli, Italy.
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39 | Exploring the role of the chemokine receptor CXCR2 in muscle stem cell heterogeneity Angela Gambardella, G. Andolfi, G. Minchiotti, O. Guardiola | Stem Cell Fate Laboratory, Institute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Naples, Italy.
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40 | Role of glucocorticoids in cancer cachexia: focus on lipocalin 2 and iron homeostasis E. Wyart1, Giada Fregnan1, M. Colombera1, A. Scalera1, A. Menga2, P.E. Porporato1 | 1Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, Italy; 2Department of Health Sciences, Center for translational Research on Autoimmune & Allergic Diseases, University of Eastern Piedmont, Novara, Italy.
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41 | SRT2104 improves muscle and cognitive outcomes and has the potential to enhance μDys gene therapy in Duchenne muscular dystrophy Laura Lociuro1, A. Arcari2, O. Gjana1, G. Scolari1, S.R. Casati1|2, S. Zecchini2, M. Giovarelli2, C. Perrotta2, C. De Palma1 | 1Department of Medical Biotechnology and Translational Medicine (BioMeTra), Università degli Studi di Milano, Segrate (MI), Italy; 2Department of Biomedical and Clinical Sciences "Luigi Sacco" (DIBIC), Università degli Studi di Milano, Italy.
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42 | RAGE-ablated skeletal muscles resist cancer-induced atrophy through Akt-GSK-3β-PGC-1α pathway and fast-to-slow myofiber transition Giulia Gentili1|2, S. Chiappalupi1|2, L. Salvadori1|3, M. Paiella1|2, K. Mangar4, A.M. Schmidt4, M. Muscaritoli5, F. Riuzzi1|2, G. Sorci1|2 | 1Department of Medicine and Surgery, University of Perugia, Perugia, Italy; 2Interuniversity Institute of Myology (IIM), Perugia, Italy; 3Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy; 4Department of Medicine, NYU Grossman School of Medicine, New York, USA; 5Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy; Giulia Gentili and S. Chiappalupi contributed equally; F. Riuzzi and G. Sorci Shared Senior authorship.
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43 | Synergistic negative effects of advanced glycation end products and tumor-conditioned medium on C2C12 myotubes and the protective activity of Vaccinium macrocarpon T. Raiteri2, Hajar Meskine1, L. Salvadori1, M. Paiella2, F. Prodam3, F. Riuzzi2, N. Filigheddu1 | 1Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy; 2Department of Medicine and Surgery, University of Perugia, Perugia, Italy; 3Department of Health Science, University of Piemonte Orientale, Novara, Italy.
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44 | Targeted delivery of mir-486 to skeletal muscle: efficacy, tropism, and integrin dependency of MYOAAV2A vs. AAV9 Chiara Ricciardi1, S. Perni1, V. Sorrentino1|2 | 1Department of Molecular and Developmental Medicine, University of Siena, Italy; 2Interdepartmental Program of Molecular Diagnosis and Pathogenetic Mechanisms of Rare Genetic Diseases, Azienda Ospedaliera Universitaria Senese, Italy.
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45 | Interleukin-4 prevents cancer-induced muscle wasting and promotes exercise-like metabolic adaptations Giacomo Rubini1, E. E. Cappellato1, L. C. Botinas1, S. Reano2, N. Filigheddu2, A. Bonetto3, F. Penna1, P. Costelli 1 | 1Dept. of Clinical and Biological Sciences, University of Turin, Italy; 2Dept. of Translational Medicine, University of Piemonte Orientale, Italy; 3Dept. of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
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46 | Investigating the impact of the tumor secretome on in vitro human skeletal and cardiac muscle models of cancer-induced cachexia Ashley Ju-Wei Wang1, L. Yedigaryan 1|2, M. Campaner Socias1, J. Zhang1, F. Palmieri3, L. Rinvenuto1, V. Marini1, R. Squecco3, M. Seelaender4, M. Sampaolesi1|5 | 1Laboratory of Translational Cardiomyology, Stem Cell Institute Leuven, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; 2IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, Illkirch, France; 3Department of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence, Italy; 4Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, São Paulo SP, Brazil; 5Histology and Medical Embryology Unit, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, Rome, Italy. | Correspondence to A. Ju-Wei Wang and M. Sampaolesi, ashley.wang@kuleuven.be; maurilio.sampaolesi@kuleuven.be.
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