Abstracts of the 22nd Meeting of the Interuniversity Institute of Myology

• Welcome to the 22^nd Meeting of the Interuniversity Institute of Myology!

  Francesca Colli, Cesare Gargioli

  https://doi.org/10.4081/ejtm.2026.15249

  138

• 01 | Investigating skeletal muscle-endothelial cell crosstalk in plasticity and disease José Fernández-Martínez^1|2, A. Gensel^1|2, E. Germinario², R.E. Oberkersch³, M.M. Santoro³, B. Blaauw^1|2 | ¹Veneto Institute of Molecular Medicine, Padua, Italy; ²Department of Biomedical Sciences, University of Padua, Italy; ³Department of Biology, University of Padua, Italy. | José Fernández-Martínez and A. Gensel contributed equally to this work.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15449

  140

• 02 | Entrainment of skeletal muscle circaldian clock by 2-hydroxybutyrate, a noval exerkine Taoyue Yang^1|2, L. Matta¹, A. Bartelt^1|3, K. Dyar¹ | ¹Institute for Diabetes and Cancer, Helmholtz Munich, Germany; ²Faculty of Medicine, Ludwig-Maximilian-Universität München, Germany; ³Traslational Nutritional Medicine, Technical University of Munich, Germany.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15450

  128

• 03 | The muscle out of breath? Limitations and adaptations in chronic diseases Angèle N. Merlet^1|2, L.A Messonnier^3|4, L. Féasson^1|2 | ¹Unité de Myologie, Service de Physiologie Clinique et de l'Exercice, Centre Référent Maladies Neuromusculaires Rares – Euro-NmD, Hôpital Universitaire de Saint-Etienne, Saint-Etienne, France; ²Laboratoire Interuniversitaire de Biologie de la Motricité, EA 7424, F-42023, Université de Lyon, UJM-Saint- Etienne, France; ³Univ. Savoie Mont Blanc, Laboratoire Interuniversitaire de Biologie de la Motricité, Chambéry, France; ⁴Institut Universitaire de France (IUF).

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15451

  108

• 04 | CD90 identifies distinct fractions of muscle stem cells with different modalities of activation and quiescence maintenance Lorenzo Marramiero^1|2, S. Di Savino^1|2, E. Kheir^1|2, M. Libergoli^1|2, S. Metti³, A. Zola^1|2, J.B. Jensen^4|5, J.Wang⁵, N. Jessen^4|5|6, F. Florio^1|2, F. Murganti^1|2, M. Belicchi ^7|8, C. Villa⁸, K. Vissing⁹, M. Verma¹⁰, L. Giordani¹¹, P. Bonaldo³, Y. Torrente^7|8, J. Farup⁴, S. Biressi^1|2 | ¹Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Povo, Italy; ²Dulbecco Telethon Institute at University of Trento, Povo, Italy; ³Department of Molecular Medicine, University of Padova, Italy; ⁴Department of Biomedicine, Aarhus University, Denmark; ⁵Steno Dia,5betes Center Aarhus, Denmark; ⁶Department of Clinical Pharmacology, Aarhus University Hospital, Denmark; ⁷Neurology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; ⁸Stem Cell Laboratory, Dino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, Italy; ⁹Department of Public Health, Aarhus University, Denmark; ¹⁰University of Texas Southwestern Medical Center, Dallas, USA; ¹¹Centre de Recherche en Myologie, Sorbonne Universités,Paris, France.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15452

  101

• 05 | Stimulation of muscle stem cells using side-streams from animal and plant production N.T. Solberg¹, J. Matic¹, G.I. Borge², K. Aabye², V. Høst¹, S.G. Wubshet¹, Mona Elisabeth Pedersen¹ | ¹Nofima AS, Ås, Norway.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15453

  94

• 06 | Pharmacological AMPK activation promotes higher levels of Pax7 expression in human muscle stem cells D. Michel¹, A. Bouche^1|2, R. Mounier³, D. Hannouche^1|2, Thomas Laumonier^1|2 | ¹Cell Therapy and Musculoskeletal Disorders Laboratory, Department of Orthopedic Surgery, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland; ²Department of Cell Physiology and Metabolism, Faculty of Medicine, Geneva, Switzerland; ³Institut Neuromyogène, CNRS 5261 – INSERM U1315 - UCBL1, Lyon, France.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15454

  90

• 07 | Role of GDF5 on macrophage polarization in the maintenance of muscle mass and function and during aging Maxime Gelin¹, E. Hemery¹, F. Truffault¹, G. Juban², C. Perrotta³, F. Pietri-Rouxel¹, M. Traoré¹, S. Falcone¹ | ¹Centre de Recherche en Myologie – U974 INSERM, Sorbonne Université, Institut de Myologie, Paris, France; ²Institut NeuroMyoGène, Physiopathologie et Génétique du Neurone et du Muscle Université Claude Bernard Lyon 1, CNRS U5261, Inserm U1315, University Lyon, Lyon, France; ³Department of Biomedical and Clinical Sciences Università degli Studi di Milano, Milan, Italy. | M. Traoré and S. Falcone contributed equally to this work and corresponding authors. s.falcone@institut-myologie.org; m.traore@institut-myologie.org.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15455

  89

• 08 | Combination therapy targeting HDAC8 and SIRT1 improves muscle integrity in a Duchenne muscular dystrophy zebrafish model Sabrina Carbone¹, A. Brix¹, L. Lociuro¹, O. Gjana¹, L. Belleri², M. Schiavone³, A. Marozzi¹, F. Del Bene², C. De Palma¹, A. Pezzotta¹, A. Pistocchi¹ | ¹Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy; ²Sorbonne Université, INSERM U968, CNRS UMR 7210, Institut de la Vision, Paris, France; ³Department of Molecular and translational medicine, Università degli Studi di Brescia, Brescia, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15456

  98

• 09 | Identification of CaVβ1 isoforms required for neuromuscular junction formation and maintenance A. Vergnol¹, A. Bourguiba¹, S. Bauché¹, M. Traoré¹, M. Gelin¹, C. Gentil¹, S. Pezet¹, L. Saillard¹, P. Meunier¹, M. Lemaitre², J. Perronnet², F. Tores³, C. Gautier⁴, Z. Guesmia¹, E. Allemand⁴, E. Batsché⁵, F. Pietri-Rouxel¹, Sestina Falcone¹ | ¹Centre de Recherche en Myologie – U974 INSERM, Sorbonne Université, Institut de Myologie, Paris, France; ²Phénotypage du petit animal – UM28 INSERM, Sorbonne Université, Paris, France; ³Institut Imagine – BIP-D Plateforme de Bioinformatique, Université Paris Cité, Paris, France; ⁴Institut Imagine – U1163 INSERM, Université Paris Cité, Paris, France; ⁵Institut de Biologie Paris-Seine (IBPS)– UMR 7238 CNRS, Sorbonne Université, Paris, France. | Corresponding authors are F. Pietri-Rouxel and S. Falcone; A. Bourguiba, S. Bauché, F. Pietri-Rouxel and S. Falcone contributed equally to this work.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15457

  90

• 10 | Human myogenic progenitor and 3D bioprinting for volumetric muscle loss recovery in swine model Rebecca Deodati, F. De Paolis, E. Guarnaccia, B. Corci, S. Bernardini, M. Costantini, C. Fuoco, C. Gargioli | Dept. of Biology, University of Tor Vergata, Rome, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15458

  84

• 11 | Human immortalized myoblasts/induced pluripotent stem cell derived skeletal muscle model to investigate cystinosis myopathy Jianhao Zhang¹, R. Mora De La Serna², M. Smits², V. Marini¹, A. Wang¹, M. Biglietto¹, M. Campaner Socias¹, L. Rinvenuto¹, Z. Ge¹, R. Gijsbers^2|3, M. Sampaolesi^1|4 | ¹Translational Cardiomyology Laboratory, Stem Cell and Developmental Biology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; ²Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium; ³Leuven Viral Vector Core, KU Leuven, Leuven, Belgium; ⁴Histology and Medical Embryology Unit, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Rome, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15459

  101

• 12 | In vitro study emulating muscle response to stimuli exploiting 3D tissue model Elena Guarnaccia, R. Deodati, F. De Paolis, B. Corci, S. Bernardini, C. Fuoco, C. Gargioli | Dept. of Biology, University of Tor Vergata, Rome, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15460

  95

• 13 | Generation of human stem cell-derived cardiac in vitro models to investigate the role of epicardial activation in adverse cardiac remodeling Margalida Campaner Socias¹, V. Marini¹, L. Rinvenuto¹, A. Wang¹, J. Zhang¹, S. Morri¹, D. Stalkopf¹, R. Oida¹, B. Sampaio¹, M. Sampaolesi^1|2 | ¹Laboratory of Translational Cardiomyology, Stem Cell and Developmental Biology Unit, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; ²Histology and Medical Embryology Unit, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, Rome, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15461

  84

• 14 | Extracellular matrix guides human neuromuscular organoid morphogenesis Beatrice Auletta^1|2|3, P. Chiolerio^1|2, G. Cecconi^1|2, L. Sartore^1|2, L. Rossi^1|2, E. Maghin⁴, S. Angiolillo^3|5, S. Calabrò¹, O. Gagliano^3|5, C. Laterza^3|5, M. Cescon¹, Y. Torrente^6|7, C. Luni⁸, M. Piccoli⁴, N. Elvassore^3|5, A. Urciuolo^1|2 | ¹Department of Molecular Medicine, University of Padova, Padova, Italy; ²Neuromuscular Engineering lab, Istituto di Ricerca Pediatrica, Città della Speranza, Padova, Italy; ³Department of Industrial Engineering, University of Padova, Padova, Italy; ⁴Tissue Engineering lab, Istituto di Ricerca Pediatrica, Città della Speranza, Padova, Italy; ⁵Veneto Institute of Molecular Medicine, Padova, Italy; ⁶Stem Cell Laboratory, Dino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; ⁷Neurology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; ⁸Department of Civil, Chemical, Environmental and Materials Engineering (DICAM), University of Bologna, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15462

  97

• 15 | GDF5 therapeutic potential for Duchenne muscular dystrophy C. Gentil, A. Bourguiba, A. Vergnol, B. Cadot, Z. Guesmia, L. Saillard, P. Meunier, S. Falcone, L. Giordani, France Pietri-Rouxel | Sorbonne Université, INSERM, Institut de Myologie, Centre de Recherche en Myologie, Paris, France.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15463

  100

• 16 | Immunoproteasome inhibition positively impacts the gut-muscle axis in Duchenne muscular dystrophy Debora Mostosi¹, A. Farini², F. Strati³, M. Molinaro², S. Saccone², C. Amoroso³, B. Cassani⁴, E. Leonetti¹, F. Caprioli⁵, F. Facciotti³, Y. Torrente^1|2 | ¹Stem Cell Laboratory, Dino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; ²Neurology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; ³Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy; ⁴Department of Medical Biotechnologies and Translational Medicine, University of Milan, Italy; ⁵Department of Pathophysiology and Transplantation, University of Milan, Unit of Gastroenterology and Endoscopy, Fondazione IRCCS Ca’ Granda, Ospedale Policlinico di Milano, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15464

  86

• 17 | The evolving role of patient organizations in neuromuscular research: integrating the patient voice through registries and collaborative initiatives Ilaria Zito, F. de Angelis, F. Mattei | Parent Project aps, Roma, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15465

  77

• 18 | Double-edge sword of ketogenic diet: hepatic improvement at the expense of musculoskeletal health Alessandro Antonioli¹, T. Raiteri², A. Provera¹, S. Reano³, S. Tini¹, S. Sutti¹, N. Filigheddu³, F. Prodam¹ | ¹Department of Health Sciences, University of Piemonte Orientale, Novara, Italy; ²Department of Medicine and Surgery, University of Perugia, Perugia, Italy; ³Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15466

  102

• 19 | Cachexia displays a unique pattern of gait alterations indicating a neurodegenerative condition Gaelle Revet¹, K. Jangwa-Etame¹, P. Joanne¹, A. Diko¹, M. Mangone², A. Molfino², Z. Li¹, O. Agbulut¹, D. Coletti² | ¹Sorbonne University, Paris, France; ²Sapienza University of Rome, Rome, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15467

  85

• 20 | Exercise preserves purkinje cells' integrity from paraneoplastic cerebellar degeneration in a mouse model of cachexia Francesco Paolo Zummo, V. Sagagandomabadi, R. Barone, F. Macaluso, D. D'Amico, M. Sausa, F. Carini, V. Di Felice, S. David | Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15468

  91

• 21 | Transcriptional and metabolic analyses of cardiac mononucleated cells in dystrophic mdx mice upon treatment with a specific monoamino oxidase B inhibitor Francesca Fontana^1|2, F.C. Venegas^3|4, E. Baldisseri^3|4, R. Sánchez-Rodríguez^3|4, A. Reggio⁵, A. Palma⁶, M. Canton^3|4, L. Vitiello¹ | ¹Department of Biology, University of Padova, Italy; ²Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Italy; ³Fondazione Istituto di Ricerca Pediatrica Città della Speranza, IRP, Italy; ⁴Department of Biomedical Sciences, University of Padova, Italy; ⁵Saint Camillus International University of Health Sciences, Italy; ⁶Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15469

  97

• 22 | Subcutaneous injection of microencapsulated Sertoli cells is more efficacious than deflazacort treatment in mdx mice Sara Chiappalupi^1|2, G. Gentili^1|2, L. Salvadori^2|3, I. Arato¹, F. Mancuso¹, M. Paiella^1|2, F. Riuzzi^1|2, R. Calafiore¹, G. Luca¹, G. Sorci^1|2 | ¹Department of Medicine and Surgery, University of Perugia, Italy; ²Interuniversity Institute of Myology (IIM), Perugia, Italy; ³Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy. | S. Chiappalupi and G. Sorci shared Senior authorship; S. Chiappalupi and G. Gentili contributed equally.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15470

  90

• 23 | Preclinical evaluation of 3s-HMGB1 as a therapeutic strategy for Duchenne muscular dystrophy Federica Esposito¹, E. Sbolli¹, S. Curtarello¹, E. Ruggieri^1|2, M. Patrone^1|2, M. Rodrigues³, V. Taglietti³, F. Relaix³, E. Vénéreau^1|2 | ¹Unit, Division of Genetics and Cellular Biology, IRCCS Ospedale San Raffaele, Milan, Italy; ²University Vita-Salute San Raffaele, Milan, Italy; ³Univ Paris-Est Créteil, INSERM, U955 IMRB, Créteil, France.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15471

  83

• 24 | Smooth muscle cells from human vagina express functional transient receptor potential channels Francesco Palmieri¹, R. Garella¹, I. Cellai², G. Guarnieri¹, E. Maseroli², S. Cipirani², M. Annunziato², P. Comeglio², A. Morelli¹, M. Maggi², L. Vignozzi², R. Squecco¹ | ¹Dip. di Medicina Sperimentale e Clinica, Università di Firenze, Italy; ²Dip. di Scienze Biomediche Sperimentali e Cliniche, Università di Firenze, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15472

  85

• 25 | Target adipogenic progenitors to cure Duchenne muscular dystrophy Luca Sali¹, B. Periou², A. Cojocaru¹, E. Giry¹, G. Severa², L. Giordani³, V. Taglietti¹, E. Malfatti^1|2 | ¹Univ. Paris-Est Créteil, INSERM, U955 IMRB, Créteil, France; ²Assistance Publique-Hôpitaux de Paris, Centre de Référence de Pathologie Neuromusculaire Nord-Est-Ile-de-France, Filnemus, Hôpital Henri Mondor, Créteil, France; European Reference Center for Neuromuscular Disorders, EURO-NMD, France; ³Sorbonne Université, INSERM UMRS 974, Association Institut de Myologie, Centre de Recherche en Myologie, Paris, France.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15473

  86

• 26 | Validation of a new multi-target antioxidant treatment for the therapy of Duchenne muscular dystrophy F. Fontana^1|2, F. Carozzi¹, G. Piccoli³, L. Nogara³, G. Romagnoli², E. Petricci², B. Blaauw³, M. Canton³, Libero Vitiello¹, F. Galvagni² | ¹Dept. of Biology, Univ. of Padova, Italy; ²Dept. of Biotechnology, Chemistry and Pharmacy, Univ. of Siena, Italy; ³Dept. of Biomedical Sciences, Univ. of Padova, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15474

  89

• 27 | Polymeric nanoparticles as a favorable delivery system to enhance the anti-inflammatory action of n-palmitoylethanolamide, an endocannabinoid-like molecule E. Maretti¹, C. Rustichelli¹, B. Recchia¹, G. Battaglia, E. de Nicola¹, C. Fuoco², A. Votta³, C. Gargioli², E. Ferraro³, E. Leo¹, Susanna Molinari¹ | ¹Dept. of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy; ²Dept. Of Biology, Tor Vergata Rome University, Rome, Italy; ³Dept. of Biology, University of Pisa, Pisa, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15475

  87

• 28 | Impairment of skeletal muscle force and mitochondrial respiratory capacity precedes muscle mass loss in an aged murine model of diet-induced obesity Clara Sciorati¹, R. De Lorenzo^1|2, A. Avola¹, M. Giovarelli³, C. De Palma³, E. Clementi³, C. Lanzani¹, P. Rovere-Querini^1|2 | ¹IRCCS San Raffaele Hospital Scientific Institute, Milan, Italy; ²Vita-Salute San Raffaele University, Milan, Italy; ³Department of Biomedical and Clinical Science, University of Milan, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15476

  88

• 29 | RNA-based combinatorial multi-target therapy for the treatment of Duchenne muscular dystrophy Mathieu Horeau, C. Pezzini, M. Sandri | Department of Biomedical Sciences, University of Padova, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15477

  92

• 30 | The advanced glycation end-products (ages)/rage axis drives sarcobesity, which is restrained by Vaccinium macrocarpon extract Martina Paiella^1|2, L. Salvadori^2|3, T. Raiteri^1|2, G. Gentili^1|2, S. Chiappalupi^1|2, T. Manenti⁴, G. Sorci^1|2, F. Prodam⁵, N. Filigheddu^2|3, F. Riuzzi^1|2 | ¹Dept. Medicine and Surgery, Univ. Perugia, Perugia, Italy; ²Interuniversity Institute of Myology (IIM), Perugia, Italy; ³Dept. Translational Medicine, Univ. Piemonte Orientale, Novara, Italy; ⁴Laboratori Biokyma srl, Anghiari, Italy; ⁵Dept. Health Science, Univ. Piemonte Orientale, Novara, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15478

  97

• 31 | Exon skipping peptide-conjugated morpholinos downregulate dynamin 2 to rescue centronuclear myopathy Foteini Moschovaki-Filippidou¹, J. de Carvalho Neves¹, N. Diedhiou¹, Y. Jad^2|3, J. Böhm¹, M.J.A. Wood^2|3, M.A. Varela^2|3, J. Laporte¹ | ¹IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, Illkirch, France; ²Department of Paediatrics, Institute of Developmental and Regenerative Medicine (IDRM), University of Oxford, UK; ³MDUK Oxford Neuromuscular Centre, Oxford, UK.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15479

  90

• 32 | Trifolium pratense extract mitigates skeletal muscle atrophy: a nutraceutical approach for the prevention of sarcopenia Tommaso Raiteri¹, H. Meskine², M. Paiella¹, A. Trabalzini¹, I. Varfaj⁴, L. Salvadori², F. Riuzzi¹, R. Sardella⁴, F. Orlandi³, N. Filigheddu², G. Sorci¹ | ¹Department of Medicine and Surgery, University of Perugia, Italy; ²Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy; ³Department of Civil and Environmental Engineering, University of Perugia, Italy; ⁴Department of Pharmaceutical Sciences, University of Perugia, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15480

  93

• 33 | Identification of mTORC1-dependent muscle-specific factors involved in neuromuscular junction maintenance Paula Aranda-Martínez¹, M. Baraldo², S. Zorzato¹, H. Nolte³, B. Blaauw¹ | ¹Department of Biomedical Sciences, Padua Univ., Italy; ²Biozentrum, Basel Univ., Basel; ³Max Planck Institute for Biology of Ageing, Cologne.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15481

  92

• 34 | Hyaluronan enhances proliferation and myogenic differentiation of C2C12 murine myoblasts under inflammatory stress Fabio Ferrini, G. Annibalini, M. Battistelli, F. Fanelli, S. Moosavi, R. Osman, I. Capparucci, P. Sestili, E. Barbieri | Dept. of biomolecular sciences, University of Urbino, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15482

  86

• 35 | A novel 3D skeletal muscle model to study cancer cachexia R. Wüst¹, L. Terrie¹, A. Weisrock^1|2, L. Thorrez¹, Emanuele Berardi¹ | ¹Tissue Engineering Lab, Department of Development and Regeneration, KU Leuven Kulak, Kortrijk, Belgium; ²Univ. Lille, CNRS, Centrale Lille, UMR 9013, LaMcube, Lille, France.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15483

  83

• 36 | The effects of heat stress and exercise on skeletal muscle Chiara Malerba¹, A. Laurino¹, M. Serano, C. Pranzo¹, F. Fiore¹, E. Pierantozzi¹, D. Rossi^1|2, V. Sorrentino^1|2 | ¹Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy; ²Azienda Ospedaliero Universitaria Senese, Siena, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15484

  93

• 37 | Characterization of novel cancer cachexia preclinical models implementing chemotherapy and surgery Emma Elisabeth Cappellato, C. Fornelli, N.E. Cortez, V. Schiavo, P. Costelli, F. Penna | Department of Clinical and Biological Sciences, University of Torino, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15485

  84

• 38 | Effects of chronic treatment with conjugated linoleic acid on antioxidant gene expression and oxidative stress in SOD1-G93A mouse model of amyotrophic lateral sclerosis Letizia Claudione¹, B. Boccanegra¹, P. Mantuano¹, F. Bacchetti², M. Milanese², P. Bergamo³, A. De Luca¹, S. Pierno¹ | ¹Section of Pharmacology, Dept. of Pharmacy and Drug Sciences, University of Bari Aldo Moro, Bari, Italy; ²Dept. of Pharmacy, University of Genova, Genova, Italy; ³Institute of Biosciences and Bio-Resources, CNR, Napoli, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15486

  86

• 39 | Exploring the role of the chemokine receptor CXCR2 in muscle stem cell heterogeneity Angela Gambardella, G. Andolfi, G. Minchiotti, O. Guardiola | Stem Cell Fate Laboratory, Institute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Naples, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15487

  86

• 40 | Role of glucocorticoids in cancer cachexia: focus on lipocalin 2 and iron homeostasis E. Wyart¹, Giada Fregnan¹, M. Colombera¹, A. Scalera¹, A. Menga², P.E. Porporato¹ | ¹Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, Italy; ²Department of Health Sciences, Center for translational Research on Autoimmune & Allergic Diseases, University of Eastern Piedmont, Novara, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15488

  90

• 41 | SRT2104 improves muscle and cognitive outcomes and has the potential to enhance μDys gene therapy in Duchenne muscular dystrophy Laura Lociuro¹, A. Arcari², O. Gjana¹, G. Scolari¹, S.R. Casati^1|2, S. Zecchini², M. Giovarelli², C. Perrotta², C. De Palma¹ | ¹Department of Medical Biotechnology and Translational Medicine (BioMeTra), Università degli Studi di Milano, Segrate (MI), Italy; ²Department of Biomedical and Clinical Sciences "Luigi Sacco" (DIBIC), Università degli Studi di Milano, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15489

  83

• 42 | RAGE-ablated skeletal muscles resist cancer-induced atrophy through Akt-GSK-3β-PGC-1α pathway and fast-to-slow myofiber transition Giulia Gentili^1|2, S. Chiappalupi^1|2, L. Salvadori^1|3, M. Paiella^1|2, K. Mangar⁴, A.M. Schmidt⁴, M. Muscaritoli⁵, F. Riuzzi^1|2, G. Sorci^1|2 | ¹Department of Medicine and Surgery, University of Perugia, Perugia, Italy; ²Interuniversity Institute of Myology (IIM), Perugia, Italy; ³Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy; ⁴Department of Medicine, NYU Grossman School of Medicine, New York, USA; ⁵Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy; Giulia Gentili and S. Chiappalupi contributed equally; F. Riuzzi and G. Sorci Shared Senior authorship.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15490

  92

• 43 | Synergistic negative effects of advanced glycation end products and tumor-conditioned medium on C2C12 myotubes and the protective activity of Vaccinium macrocarpon T. Raiteri², Hajar Meskine¹, L. Salvadori¹, M. Paiella², F. Prodam³, F. Riuzzi², N. Filigheddu¹ | ¹Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy; ²Department of Medicine and Surgery, University of Perugia, Perugia, Italy; ³Department of Health Science, University of Piemonte Orientale, Novara, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15491

  87

• 44 | Targeted delivery of mir-486 to skeletal muscle: efficacy, tropism, and integrin dependency of MYOAAV2A vs. AAV9 Chiara Ricciardi¹, S. Perni¹, V. Sorrentino^1|2 | ¹Department of Molecular and Developmental Medicine, University of Siena, Italy; ²Interdepartmental Program of Molecular Diagnosis and Pathogenetic Mechanisms of Rare Genetic Diseases, Azienda Ospedaliera Universitaria Senese, Italy.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15492

  100

• 45 | Interleukin-4 prevents cancer-induced muscle wasting and promotes exercise-like metabolic adaptations Giacomo Rubini¹, E. E. Cappellato¹, L. C. Botinas¹, S. Reano², N. Filigheddu², A. Bonetto³, F. Penna¹, P. Costelli ¹ | ¹Dept. of Clinical and Biological Sciences, University of Turin, Italy; ²Dept. of Translational Medicine, University of Piemonte Orientale, Italy; ³Dept. of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15493

  98

• 46 | Investigating the impact of the tumor secretome on in vitro human skeletal and cardiac muscle models of cancer-induced cachexia Ashley Ju-Wei Wang¹, L. Yedigaryan ^1|2, M. Campaner Socias¹, J. Zhang¹, F. Palmieri³, L. Rinvenuto¹, V. Marini¹, R. Squecco³, M. Seelaender⁴, M. Sampaolesi^1|5 | ¹Laboratory of Translational Cardiomyology, Stem Cell Institute Leuven, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; ²IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, Illkirch, France; ³Department of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence, Italy; ⁴Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, São Paulo SP, Brazil; ⁵Histology and Medical Embryology Unit, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, Rome, Italy. | Correspondence to A. Ju-Wei Wang and M. Sampaolesi, ashley.wang@kuleuven.be; maurilio.sampaolesi@kuleuven.be.

  Interuniversity Institute of Myology

  https://doi.org/10.4081/ejtm.2026.15494

  106