European Journal of Translational Myology <p>The <strong>European Journal of Translational Myology</strong> (formerly known as <em>Basic and Applied Myology</em>) is the European reference forum for Translational Myology. The <strong>European Journal of Translational Myology</strong>&nbsp;is a multifaceted journal studying myology from various perspectives: basic, cellular and molecular, genetic, clinical, and translational proper.</p> en-US <p><strong>PAGEPress</strong> has chosen to apply the&nbsp;<a href="" target="_blank" rel="noopener"><strong>Creative Commons Attribution NonCommercial 4.0 International License</strong></a>&nbsp;(CC BY-NC 4.0) to all manuscripts to be published.<br><br> An Open Access Publication is one that meets the following two conditions:</p> <ol> <li>the author(s) and copyright holder(s) grant(s) to all users a free, irrevocable, worldwide, perpetual right of access to, and a license to copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship, as well as the right to make small numbers of printed copies for their personal use.</li> <li>a complete version of the work and all supplemental materials, including a copy of the permission as stated above, in a suitable standard electronic format is deposited immediately upon initial publication in at least one online repository that is supported by an academic institution, scholarly society, government agency, or other well-established organization that seeks to enable open access, unrestricted distribution, interoperability, and long-term archiving.</li> </ol> <p>Authors who publish with this journal agree to the following terms:</p> <ol> <li>Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.</li> <li>Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.</li> <li>Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.</li> </ol> (Francesca Baccino) (Tiziano Taccini) Fri, 11 Jan 2019 00:00:00 +0100 OJS 60 2019 Ejtm Special on Muscle Fascia <p>For many years the fasciae have been considered by the anatomists only as a “white envelope for the muscles”, that is generally removed in anatomical tables, to recognize muscle nerves and vessels. This is one of the reasons that different descriptions of the fasciae exist. On the other hand, in the last years the fasciae and their properties are becoming of central importance to clinicians practicing in various conventional and alternative therapies. The results from the worldwide research activities constitute a body of significant and important data, but this clinical interest is not supported by in-depth comprehension to how integrate the new knowledge about fasciae with the classical biomechanical models based on muscles, tendons and bones. To close this gap an Ejtm Special on “Muscle Fascia” will be published September 30, 2019, but the typescripts will be added to the Ejtm Early Release list as soon as all authors will approve their Epub papers. Deadline for original articles and reviews is June 1st, 2019, but the Editors hope that authors submit their typescripts much earlier.</p> Carla Stecco, Raffaele De Caro ##submission.copyrightStatement## Thu, 28 Feb 2019 09:45:33 +0100 Therapeutic strategies against cancer cachexia <p>Cancer cachexia has two main components: anorexia and metabolic alterations. The main changes associated with the development of this multi-organic syndrome are glucose intolerance, fat depletion and muscle protein hypercatabolism. The aim of this paper is to review the more recent therapeutic approaches designed to counteract the wasting suffered by the cancer patient with cachexia. Among the most promising approaches we can include the use of ghrelin agonists, beta-blockers, beta-adrenergic agonists, androgen receptor agonists and anti-myostatin peptides. The multi-targeted approach seems essential in these treatments, which should include the combination of both nutritional support, drugs and a suitable program of physical exercise, in order to ameliorate both anorexia and the metabolic changes associated with cachexia. In addition, another very important and crucial aspect to be taken into consideration in the design of clinical trials for the treatment of cancer cachexia is to staging cancer patients in relation with the degree of cachexia, in order to start as early as possible this triple approach in the course of the disease, even before the weight loss can be detected.</p> Josep M. Argilés, Francisco Javier López-Soriano, Britta Stemmler, Silvia Busquets ##submission.copyrightStatement## Wed, 27 Feb 2019 15:23:33 +0100 Comparison of single- and multi-joint lower body resistance training upon strength increases in recreationally active males and females: a within-participant unilateral training study <p>The present study compared strength increases resulting from either single-joint (SJ) or multi-joint (MJ) lower body resistance exercise. A within-participants design was utilised. Ten recreationally active participants (males; n=5, and females; n=5) had their lower limbs randomly allocated to perform both unilateral MJ (leg press; LP) and unilateral SJ (knee extension; KE, and seated knee flexion; KF) exercises. Participants trained 2 d.week-1 for 6 weeks. Pre- and post-intervention maximal strength (1-repetition maximum; 1RM) was measured for leg press, knee extension, and seated knee flexion exercises. Statistically significant strength increases occurred for both SJ and MJ groups, with significantly greater increases in 1RM for the MJ compared to the SJ group (p &lt; 0.001 for all exercises). This study supports the use of MJ exercise for strength increases across lower body MJ and SJ movements, suggesting a time-efficient, and simple approach to resistance training may be efficacious. This might serve to promote greater adherence in the lay population as well as serving useful for rehabilitation professionals and strength and conditioning coaches in managing resistance exercise around skill/sport specific training.</p> Alexander Goncalves, Paulo Gentil, James Steele, Jürgen Giessing, Antonio Paoli, James P. Fisher ##submission.copyrightStatement## Wed, 27 Feb 2019 15:08:21 +0100 Investigation of Iranian pomegranate cultivars for wound healing components <p>One of the most important issues which medical science has been facing is wound healing for the tissue repair with the least complications. In this study, we aimed to isolate, purify and quantitate tannins and phenolic compounds from exocarp and pulp of fruits of Iranian pomegranate cultivars. Our findings demonstrate that the highest amount of tannin extracts from ethanol extract of the black peel exocarp was 201.76 ± 1.93. The highest amount of flavonoids from the ethanol extract of Sweet Alac exocarp was119.69 ± 1.02 as well as antioxidant compounds activity in the exocarp and pulp showed that the highest activity is in the ethanol extract of the black peel was 95.65 ± 3.1. The total phenolic activity indicated that the Sour white peel ethanol extract has the highest phenolic activity 327.05 ± 863. Our data suggest that the ethanol extract of pomegranate exocarp has the higher amounts of tannins and flavonoids, compounds that are known to be beneficial for wound healing. Taken together, these data suggest that compounds isolated from Iranian pomegranate cultivars offer new options for managements of wound healing.</p> Mohammad Omidi Ghaleh Mohammadi, Sayid Mahdi Mirghazanfari ##submission.copyrightStatement## Tue, 22 Jan 2019 08:40:43 +0100 Comparison of intradermal Dexmedmotidine and subcutaneous Ketamine for post-surgical pain management in patients with abdominal hysterectomy <p>Hysterectomy after cesarean section is the second most commonly used surgery for women in the United States. One of the most common problem after hysterectomy is pain. We decided to compare the effects of dexmedmotidine or ketamine on pain in patients by a double blind randomized clinical trial on 126 female candidates for abdominal hysterectomy in three groups of 42 persons referred to Taleghani hospital in Arak. For the first group, 50 micrograms of intradermal dexmedmotidine were injected, while in the second group, patients were injected with 100 mg of subcutaneous ketamine and the third group received 5 cc normal saline. Data were next analyzed by SPSS version 19. The mean age and body mass index of the patients were not significantly different in the three groups. The mean scores of pain during recovery of patients in ketamine, dexmedmotidine and placebo groups were 4.2±0.77, 2.6±0.89 and 1.3±0.87, respectively (p = 0.001). Scores of pain in patients at 4 and 8 hours after surgery showed also significant differences. In conclusion, ketamine and dexmedmotidine significantly reduce the severity of pain, but ketamine has a lower effect.</p> Alireza Kamali, Zahra Zarepour, Maryam Shokrpour, Shirin Pazuki ##submission.copyrightStatement## Fri, 11 Jan 2019 13:54:23 +0100 Peripheral axotomy-induced changes of motor function and histological structure of spinal anterior horn <p>The aim of this study was to evaluate changes of both peripheral motor function and histology of spinal anterior horn in adult rats after unilateral sciatectomy. Ten adult healthy rats served as control group, while in the ten rat experimental group the right sciatic nerve was severed. We followed-up nerve motor function using a sciatic function index and electromyography activity of the gastrocnemious muscle. The rats of the experimental group presented the expected gross locomotor deficit and leg muscle atrophy. At 12 weeks post sciatectomy, L4 and L5 spinal cord segments were removed from the twenty rats and were analysed by istological stereological methods. In the axotomized animals volume of the anterior horn and its content of motor neurons decreased, while the content of astrocytes increased (p &lt; 0.05). Thus, in adult rats, beside the obvious peripheral nerve disfuction, the sciatic nerve axotomy have severe consequences on the soma of the injured motor neurons in the spinal anterior horn. All these quantitative analyses may be usefull to quantify changes occurring in adult animals after axotomy and eventual management to modify the final outcomes in peripheral nerve disorders.</p> Amir Raoofi, Mohammad Amin Abdollahifar, Abbas Aliaghaei, Abbas Piryaei, Fatemeh Hejazi, Ensieh Sajadi, Ali Rashidiani-Rashidabadi, Yousef Sadeghi ##submission.copyrightStatement## Thu, 17 Jan 2019 09:08:57 +0100 2019Spring PaduaMuscleDays: Translational Myology and Mobility Medicine <p>A half-century tradition of skeletal muscles studies, started with a research on fever, is continuing under the auspices of the Interdepartmental Research Centre of Myology (CIR-Myo), Department of Biomedical Sciences, University of Padova, Italy, the AandC M-C Foundation for Translational Myology, Padova, Italy and the European Journal of Translational Myology (EJTM). This year an EJTM Special will be dedicated to Muscle Fascia, an under looked topic, which merits more attention. Furthermore, this year the 2019SpringPaduaMuscleDays: Translational Myology and Mobility Medicine, an International Conference, was held March 28-30, 2019 in Euganei Hills and Padova (Italy). The abstracts of the 2019SpPMD, that are reported in the Myology News of EJTM 29 (1), 2019, are excellent examples of translational research. Their excellent contents are at the level needed for approval by Ethical Committees, International Granting Agencies, and Editors of international journals, thanks to the high scientific profiles of researchers and clinicians who are eager to present their results at the PaduaMuscleDays.</p> Ugo Carraro ##submission.copyrightStatement## Thu, 21 Feb 2019 09:41:17 +0100 Collection of the Abstracts of the 2019Sp PMD: Translational Myology and Mobility Medicine <p>The Interdepartmental Research Centre of Myology (CIR-Myo), Department of Biomedical Sciences, University of Padova, Italy and the AandC M-C Foundation for Translational Myology, Padova, Italy organized with the scientific support of Helmut Kern, Jonathan C. Jarvis, Viviana Moresi, Marco Narici, Feliciano Protasi, Marco Sandri and Ugo Carraro, the 2019SpringPaduaMuscleDays: Translational Myology and Mobility Medicine, an International Conference held March 28-30, 2019 in Euganei Hills and Padova (Italy). Presentations and discussions of the Three Physiology Lectures and of the seven Sessions (I: Spinal Cord Neuromodulation and h-bFES in SC; II: Muscle epigenetics in aging and myopathies; III: Experimental approaches in animal models; IV: Face and Voice Rejuvenation; V: Muscle Imaging; VI: Official Meeting of the EU Center of Active Aging; VII: Early Rehabilitation after knee and hip replacement) were at very high levels. This was true in the past and will be true in future events thanks to researchers and clinicians who were and are eager to attend the PaduaMuscleDays.</p> Ugo Carraro ##submission.copyrightStatement## Mon, 11 Mar 2019 10:23:12 +0100