European Journal of Translational Myology <p>The <strong>European Journal of Translational Myology</strong> (formerly known as <em>Basic and Applied Myology</em>) is the European reference forum for Translational Myology. The <strong>European Journal of Translational Myology</strong>&nbsp;is a multifaceted journal studying myology from various perspectives: basic, cellular and molecular, genetic, clinical, and translational proper.</p> PAGEPress Scientific Publications, Pavia, Italy en-US European Journal of Translational Myology 2037-7452 <p><strong>PAGEPress</strong> has chosen to apply the&nbsp;<a href="" target="_blank" rel="noopener"><strong>Creative Commons Attribution NonCommercial 4.0 International License</strong></a>&nbsp;(CC BY-NC 4.0) to all manuscripts to be published.<br><br> An Open Access Publication is one that meets the following two conditions:</p> <ol> <li>the author(s) and copyright holder(s) grant(s) to all users a free, irrevocable, worldwide, perpetual right of access to, and a license to copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship, as well as the right to make small numbers of printed copies for their personal use.</li> <li>a complete version of the work and all supplemental materials, including a copy of the permission as stated above, in a suitable standard electronic format is deposited immediately upon initial publication in at least one online repository that is supported by an academic institution, scholarly society, government agency, or other well-established organization that seeks to enable open access, unrestricted distribution, interoperability, and long-term archiving.</li> </ol> <p>Authors who publish with this journal agree to the following terms:</p> <ol> <li>Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.</li> <li>Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.</li> <li>Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.</li> </ol> 2020 Distance Meeting: Farewell to Professor David Yaffe - A pillar of the Myogenesis Field <p>David Yaffe, PhD passed away on July 3, 2020 at the age of 91. His funeral and burial were held at his kibbutz in Israel, Givat Brenner. At the time of his death, he was emeritus professor of molecular cell biology at the Weizmann Institute of Science. If there is one word to describe David, it would be “pioneer”, Halutz in Hebrew. He participated in the birth of his country as a soldier during the War of Independence, contributed his efforts to expanding the kibbutz movement and the nascent scientific community in Israel. He was a major figure in creating the field of muscle cell biology by generating the immortalized cell lines that could be induced to differentiate into muscle fibers in tissue culture. This made myogenesis a prime candidate for studying cell differentiation, accessible to hundreds of scientists during the dawn of molecular cell biology. Many prominent scientists, among them students of David made their careers on studying the molecular events that occurred as the myoblast cell lines developed into the syncytial myofibers that twitched spontaneously. This opened the field to studies on muscle diseases, such as muscular dystrophy, that could then be addressed through a tractable model for molecular studies. David claimed he was never paid for his scientific activities; his salary at the Weizmann Institute went directly to the kibbutz in compensation for his time taken away from work there. He never knew what his salary was, he said, since it was negotiated between the kibbutz and the Weizmann. Even so, he had to take off weeks from his science occasionally to perform daily tasks, usually in the kibbutz dining hall washing dishes. Disconnected from the material aspects of life, David was driven solely by his love for nature and science, which he continued until the very end. David remains an inspiration to all of us. In this issue several of David Yaffe’s lab members, pupils, coauthors and colleagues meet at a “David Yaffe myogenesis distance meeting" to pay tribute with their collective reflections.</p> Robert H. Singer Copyright (c) 2020 The Authors 2020-09-09 2020-09-09 30 3 10.4081/ejtm.2020.9327 Neuro-mechanical aspects of playing-related mobility disorders in orchestra violinists and upper strings players: a review <p>Orchestra musicians are at high risk of neuro-mechanical disorders due to the intense stresses their body withstand, leading to pain and injury. This review presents a comprehensive account of the works on the circumstances and types of playing related mobility disorders of upper strings players, as well as on the relevant neuro-mechanical factors and perspectives to those disorders. The following aspects are considered: asymmetry and imbalance in the musculo-skeletal system, muscle-bone-joint interactions, repetitive overloading and fatigue. An additional factor relates to neuro-muscular redundancy in the motor system, whereby more muscles and tendons than strictly necessary are engaged in performing a motor task, thus making the system indeterminate, with no unique solution. This same task can be performed with different muscle combinations. It is thus of interest to verify whether playing disorders may be alleviated by considering alternative techniques of performance.</p> Joseph Mizrahi Copyright (c) 2020 The Authors 2020-08-04 2020-08-04 30 3 10.4081/ejtm.2020.9095 Muscle hypertrophy and muscle strength: dependent or independent variables? A provocative review <p>The question whether the muscle hypertrophy induced by resistance training, hormone administration or genetic manipulation is accompanied by a proportional increase in muscle strength is still open. This review summarizes and analyses data obtained in human and rodent muscles in studies that have monitored in parallel changes in muscle size and changes in muscle force, measured in isometric contractions in vivo, in isolated muscles ex vivo (in rodents) and in single muscle fibers. Although a general positive relation exists among the two variables, a number of studies show a clear dissociation with increase of muscle size with no change or even decrease in strength and, vice versa, increase in strength without increase in size. The possible mechanisms of such dissociation, which involves neural motor control and/or cellular and molecular adaptations of muscle fibers, are briefly discussed.</p> Carlo Reggiani Stefano Schiaffino Copyright (c) 2020 The Authors 2020-09-09 2020-09-09 30 3 10.4081/ejtm.2020.9311 Effect of adding dexmedetomidine or remifentanil to thiopental in patients with mood disorder candidate for electroconvulsive therapy <p>Electroconvulsive therapy (ECT) is one of the appropriate treatments for many neuropsychiatric patients, especially those with mood disorders. Short-term complications of ECT include agitation and postictal. In this study, we compared the addition of dexmedetomidine or remifentanil to thiopental as the main anaesthetic used in ECT. In this double-blind randomised clinical trial, 90 patients with mood disorders (candidates for ECT) were divided into two groups based on their therapy: dexmedetomidine or remifentanil. In the first group (DG), patients were slowly injected intravenously with 0.5 μg/kg dexmedetomidine before induction of anesthesia. In the second group (GR), 100 μg of remifentanil was slowly injected intravenously.In addition, we collected demographic information such as respiratory rate, heart pulse rate, seizure time, mean of arterial blood pressure, recovery duration and the oxygen arterial saturation recorded after recovery. Data obtained were analysed by use of statistical software, SPSS-23. The mean age of both groups was approximately 37 years with the majority being men. There was no significant difference between the two groups in terms of age and sex, blood pressure, heart rate, duration of seizures and arterial oxygen saturation before ECT. The mean blood pressure and heart rate in the recovery group were lower in the dexmedetomidine group than in the remifentanil group and the hemodynamics in the dexmedetomidine group were more stable. The recovery time in the dexmedetomidine group was longer than that of the remifentanil group (p = 0.001). Both groups had approximately the same satisfaction and the rate of agitation after ECT was the same. Both remifentanil and dexmedetomidine as adjuvants lead to a decrease in patients' post-ECT hyperdynamic responses. In our study, we demonstrated that the effect of dexmedetomidine is greater than remifentanil. On the other hand, neither dexmedetomidine nor remifentanil had a negative effect on seizure duration, but dexmedetomidine significantly prolonged recovery time, when compared to remifentanil.</p> Faezeh Heidarbeigi Hamidreza Jamilian Anita Alaghemand Alireza Kamali Copyright (c) 2020 The Authors 2020-08-04 2020-08-04 30 3 10.4081/ejtm.2020.8877 Correlation between polymorphism of TYMS gene and toxicity response to treatment with 5-fluoruracil and capecitabine <p>Tumorigenesis is a multiphasic process in which genetic alterations guide the progressive transformation in cancer cells1. In order to evaluate the possible correlation between some gene variants and the risk of the toxicity development onset, two of the polymorphisms of the thymidylate synthase (TYMS), rs34743033 (2R/3R) and rs16430 (DEL/INS) were investigated. We enrolled in our study 47 patients from the Hospital of Sicily. Our preliminary findings suggest that there could be a linkage between the genotypes discussed and the development of the toxicity following the chemotherapy treatment. These results need to be confirmed by further studies, however this short paper offers some initial insight into the relationships between genetic background and the better outcome for patients.</p> Stefano Vitello Italia Di Liegro Maria Rita Ricciardi Chiara Verga Alessandra Amato Gabriella Schiera Carlo Di Liegro Giuseppe Messina Patrizia Proia Copyright (c) 2020 The Authors 2020-08-04 2020-08-04 30 3 10.4081/ejtm.2020.8970 Analysis of the role of social support - cognitive psychology and emotional process approach <p>The eyes are extremely important for communication. The muscles around the eyes express emotional states, and the size of the pupil signals whether a person is aroused and alert or bored and fatigued. Pupil size is an overlooked social signal, yet is readily picked up by observers. Observers mirror their pupil sizes in response, which can influence social impressions. Pupil diameter is enhanced in a variety of emotional contexts, including viewing pictures, listening to sounds, and during the threat of shock. This study shows that people associate positive faces with large pupil sizes and negative faces with small pupil sizes. Although workplace social support has been described as a profoundly emotional activity, little is known about the emotional demands faced by employees or how these impacts on their well-being. This study examined relationships between ‘emotional labor,’ burnout (emotional exhaustion, depersonalization, and personal accomplishment), and job satisfaction in a sample of an employee who works in the banking sector or manufacturing sector. Also examined was whether workplace social support moderated any relationships found between emotional labor and strain. The relationship between job experience and emotional labor was also investigated.</p> Mohammad Heydari Zhou Xiaohu Mahdiye Saeidi Kin Keung Lai Yufan Shang Zheng Yuxi Copyright (c) 2020 The Authors 2020-06-23 2020-06-23 30 3 10.4081/ejtm.2020.8975 Sporadic late onset nemaline myopathy with monoclonal gammopathy of undetermined significance: two cases with long term stability <p>Monoclonal gammopathy of undetermined significance (MGUS) associated to sporadic late onset nemaline myopathy (SLONM) is a rare and severely disabling condition of quickly progressive limb girdle acquired myopathy. It is believed by some authors to be due to myotoxicity of light chain deposits. Two female patients were diagnosed with MGUS associated SLONM. In the first case, diagnosis was delayed by 6 years thus giving time for a severe generalized myopathy and cardiomyopathy to develop. A single anti-myeloma chemotherapy with lenalidomide markedly improved and stabilized the patient’s condition despite respiratory and cardiac insufficiency. In our second patient the condition was identified one year after onset of the first symptom and markedly improved after autologous bone marrow transplantation and lenalidomide. Clinicians should be aware of monoclonal gammopathy associated sporadic late onset nemaline myopathy as this acquired muscle disorder, although extremely rare, may be reversed by adequate management.</p> André Truffert Ruxandra Iancu Ferfoglia Johannes Alexander Lobrinus Kaveh Samii André Kohler Copyright (c) 2020 The Authors 2020-09-16 2020-09-16 30 3 10.4081/ejtm.2020.9225 Farewell to Professor David Yaffe – A Pillar of the Myogenesis Field <p>It is with great sadness that we have learned about the passing of Professor David Yaffe (1929-2020, Israel). Yehi Zichro Baruch - May his memory be a blessing. David was a man of family, science and nature. A native of Israel, David grew up in the historic years that preceded the birth of the State of Israel. He was a member of the group that established Kibbutz Revivim in the Negev desert, and in 1948 participated in Israel’s War of Independence. David and Ruth eventually joined Kibbutz Givat Brenner by Rehovot, permitting David to be both a kibbutz member and a life-long researcher at the Weizmann Institute of Science, where David received his PhD in 1959. David returned to the Institute after his postdoc at Stanford. Here, after several years of researching a number of tissues as models for studying the process of differentiation, David entered the myogenesis field and stayed with it to his last day. With his dedication to the field of myogenesis and his commitment to furthering the understanding of the People and the Land of Israel throughout the international scientific community, David organized the first ever myogenesis meeting that took place in Shoresh, Israel in 1975. This was followed by the 1980 myogenesis meeting at the same place and many more outstanding meetings, all of which brought together myogenesis, nature and scenery. Herein, through the preparation and publication of this current manuscript, we are meeting once again at a “David Yaffe myogenesis meeting". Some of us have been members of the Yaffe lab, some of us have known David as his national and international colleagues in the myology field. One of our contributors has also known (and communicates here) about David Yaffe’s earlier years as a kibbutznick in the Negev. Our collective reflections are a tribute to Professor David Yaffe. We are fortunate that the European Journal of Translational Myology has provided us with tremendous input and a platform for holding this 2020 distance meeting "Farwell to Professor David Yaffe - A Pillar of the Myogenesis Field".</p> Zipora Yablonka-Reuveni Frank Stockdale Uri Nudel David Israeli Helen M. Blau Asher Shainberg Sara Neuman Gania Kessler-Icekson Erica Meghid Krull Bruce Paterson Ora Saxel Fuchs David Greenberg Rachel Sarig Orna Halevy Eijiro Ozawa Don J. Katcoff Copyright (c) 2020 The Authors 2020-08-18 2020-08-18 30 3 10.4081/ejtm.2020.9306 Balance and muscle strength tests in patients with osteoporotic vertebral fractures to develop tailored rehabilitation programs <p>Authors perform a cross-sectional study of functional abilities of the patients with osteoporotic VF. Trunk muscle isometric strength and balance impairments were estimated. The development of osteoporotic VFs is associated with a significant decrease in strength of all the body muscles, especially the deep spinal stabilization system (TE, TF), where the VFs contribute to inappropriate distribution of back muscle strength with TE:TF ration of 1:1 instead of 3:2, observed both normally and in patients with uncomplicated osteoporosis. There is also a deterioration of stabilometry and functional balance assessment tests in patients with pathological VFs, which indicates abnormalities of both static and dynamic balance. The obtained data should be taken into account when developing rehabilitation programmes for patients with osteoporosis who have suffered compression VFs.</p> Ekaterina V Makarova Larisa A Marchenkova Mikhail A Eryomushkin Elena M Styazkina Ekaterina I Chesnikova Copyright (c) 2020 The Authors 2020-09-09 2020-09-09 30 3 10.4081/ejtm.2020.9236 Prospects of plasmapheresis for patients with severe COVID-19 <p>On February 11, 2020, the World Health Organization officially named the infection caused by the new coronavirus “Coronavirus disease 2019” (COVID-19). On February 11, 2020, the International Committee on Taxonomy of Viruses (ICTV) officially named the infectious matter “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2). Emergence of severe complications with new coronavirus disease is due to the development of hypercytokinaemia, also known as “cytokine storm”. These complications comprise acute respiratory distress syndrome (ARDS), respiratory failure and death. Emerging data point to the logic of using extracorporeal haemocorrection to normalise cytokine levels and reduce the severity of organ disorders. The analysis of the literature indicates that to date, a certain positive experience has been accumulated in the world in the application of extracorporeal methods in clinical practice in patients with COVID-19.</p> Ilmira R. Gilmutdinova Maksim Yu. Yakovlev Petr S. Eremin Anatoliy D. Fesun Copyright (c) 2020 The Authors 2020-09-09 2020-09-09 30 3 10.4081/ejtm.2020.9165 16th Meeting of the Interuniversity Institute of Myology (IIM) - Assisi (Italy), October 17-20, 2019: Foreword, Program and Abstracts <p>The 16th Meeting of the Interuniversity Institute of Myology (IIM), October 17-20, 2019, Assisi, Italy brought together scientists, pharma and patient organization representatives discussing new results on muscle research. Internationally renowned Keynote speakers presented advances on muscle development, homeostasis, metabolism, and disease. Speakers selected among submitted abstracts presented their new, unpublished data in seven scientific sessions. The remaining abstracts were showcased in two poster sessions. Young trainees where directly involved in the selection of keynote speakers, the organizing scientific sessions and roundtables discussions tailored to the interests of their peers. A broad Italian, European and North-American audience participated to the different initiatives. The meeting allowed muscle biology researchers to discuss ideas and scientific collaborations aimed at better understanding the mechanisms underlaying muscle diseases in order to develop better therapeutic strategies. The active participation of young trainees was facilitated by the friendly and inclusive atmosphere, which fostered lively discussions identifying emerging areas of myology research and stimulated scientific cross-fertilization. The meeting was a success and the IIM community will continue to bring forward significant contributions to the understanding of muscle development and function, the pathogenesis of muscular diseases and the development of novel therapeutic approaches. Here, we report abstracts of the meeting illustrating novel results of basic, translational, and clinical research, which confirms that the Myology field is strong and healthy.</p> Davide Gabellini Antonio Musarò Copyright (c) 2020 The Authors 2020-09-15 2020-09-15 30 3 10.4081/ejtm.2020.9345 A case report of severe veno-occlusive disease following autologous stem cell transplantation successfully treated with Defibrotide <p>Veno-occlusive disease (VOD) is one of the complications of hematopoietic stem cell transplantation that can also be caused by high-dose chemotherapy. This complication can lead to high mortality following bone marrow transplantation. It is more common after allogeneic stem cell transplantation, and is rare after autologous stem cell transplantation. While mild cases of VOD may reduce over a period of a few weeks, very severe cases can cause multi-organ damage, which has a high mortality. is therefore required with early diagnosis and treatment of this complication. In this paper, we present a sever VOD case after autologous stem cell transplantation, that was treated successfully with Defibrotide. The patient was a 14-month-old girl who has neuroblastoma with bone metastasis. VOD should be considered in the differential diagnosis of haematopoietic stem cell transplantation recipients who present with unexplained liver injuries, ascites and/or multi organ failure. Recipients of haematopoeitic stem cell transplantation who present with unexplained liver injuries, ascites and/or multi organ failure should have VOD considered in their differential diagnosis. If there is severe VOD diagnosed, then Defibrotide could be an option for treatment.</p> Gholamreza Bahoush Maryam Vafapour Copyright (c) 2020 The Authors 2020-09-15 2020-09-15 30 3 10.4081/ejtm.2020.9161