https://pagepressjournals.org/index.php/bam/issue/feed European Journal of Translational Myology 2019-03-25T17:24:45+01:00 Francesca Baccino francesca.baccino@pagepress.org Open Journal Systems <p>The <strong>European Journal of Translational Myology</strong> (formerly known as <em>Basic and Applied Myology</em>) is the European reference forum for Translational Myology. The <strong>European Journal of Translational Myology</strong>&nbsp;is a multifaceted journal studying myology from various perspectives: basic, cellular and molecular, genetic, clinical, and translational proper.</p> https://pagepressjournals.org/index.php/bam/article/view/8060 2019 Ejtm Special on Muscle Fascia 2019-03-25T17:24:40+01:00 Carla Stecco carla.stecco@unipd.it Raffaele De Caro raffaele.decaro@unipd.it <p>For many years the fasciae have been considered by the anatomists only as a “white envelope for the muscles”, that is generally removed in anatomical tables, to recognize muscle nerves and vessels. This is one of the reasons that different descriptions of the fasciae exist. On the other hand, in the last years the fasciae and their properties are becoming of central importance to clinicians practicing in various conventional and alternative therapies. The results from the worldwide research activities constitute a body of significant and important data, but this clinical interest is not supported by in-depth comprehension to how integrate the new knowledge about fasciae with the classical biomechanical models based on muscles, tendons and bones. To close this gap an Ejtm Special on “Muscle Fascia” will be published September 30, 2019, but the typescripts will be added to the Ejtm Early Release list as soon as all authors will approve their Epub papers. Deadline for original articles and reviews is June 1st, 2019, but the Editors hope that authors submit their typescripts much earlier.</p> 2019-02-28T09:45:33+01:00 ##submission.copyrightStatement## https://pagepressjournals.org/index.php/bam/article/view/7960 Therapeutic strategies against cancer cachexia 2019-03-25T17:24:40+01:00 Josep M. Argilés jargiles@ub.edu Francisco Javier López-Soriano flopez@ub.edu Britta Stemmler brittastemmler@telefonica.net Silvia Busquets silviabusquets@ub.edu <p>Cancer cachexia has two main components: anorexia and metabolic alterations. The main changes associated with the development of this multi-organic syndrome are glucose intolerance, fat depletion and muscle protein hypercatabolism. The aim of this paper is to review the more recent therapeutic approaches designed to counteract the wasting suffered by the cancer patient with cachexia. Among the most promising approaches we can include the use of ghrelin agonists, beta-blockers, beta-adrenergic agonists, androgen receptor agonists and anti-myostatin peptides. The multi-targeted approach seems essential in these treatments, which should include the combination of both nutritional support, drugs and a suitable program of physical exercise, in order to ameliorate both anorexia and the metabolic changes associated with cachexia. In addition, another very important and crucial aspect to be taken into consideration in the design of clinical trials for the treatment of cancer cachexia is to staging cancer patients in relation with the degree of cachexia, in order to start as early as possible this triple approach in the course of the disease, even before the weight loss can be detected.</p> 2019-02-27T15:23:33+01:00 ##submission.copyrightStatement## https://pagepressjournals.org/index.php/bam/article/view/8052 Comparison of single- and multi-joint lower body resistance training upon strength increases in recreationally active males and females: a within-participant unilateral training study 2019-03-25T17:24:41+01:00 Alexander Goncalves sachagoncalves@outlook.com Paulo Gentil paulogentil@hotmail.com James Steele James.steele@solent.ac.uk Jürgen Giessing giessing@uni-landau.de Antonio Paoli antonio.paoli@unipd.it James P. Fisher james.fisher@solent.ac.uk <p>The present study compared strength increases resulting from either single-joint (SJ) or multi-joint (MJ) lower body resistance exercise. A within-participants design was utilised. Ten recreationally active participants (males; n=5, and females; n=5) had their lower limbs randomly allocated to perform both unilateral MJ (leg press; LP) and unilateral SJ (knee extension; KE, and seated knee flexion; KF) exercises. Participants trained 2 d.week-1 for 6 weeks. Pre- and post-intervention maximal strength (1-repetition maximum; 1RM) was measured for leg press, knee extension, and seated knee flexion exercises. Statistically significant strength increases occurred for both SJ and MJ groups, with significantly greater increases in 1RM for the MJ compared to the SJ group (p &lt; 0.001 for all exercises). This study supports the use of MJ exercise for strength increases across lower body MJ and SJ movements, suggesting a time-efficient, and simple approach to resistance training may be efficacious. This might serve to promote greater adherence in the lay population as well as serving useful for rehabilitation professionals and strength and conditioning coaches in managing resistance exercise around skill/sport specific training.</p> 2019-02-27T15:08:21+01:00 ##submission.copyrightStatement## https://pagepressjournals.org/index.php/bam/article/view/7995 Investigation of Iranian pomegranate cultivars for wound healing components 2019-03-25T17:24:43+01:00 Mohammad Omidi Ghaleh Mohammadi m.omidighale@ut.ac.ir Sayid Mahdi Mirghazanfari smmirghazanfari@gmail.com <p>One of the most important issues which medical science has been facing is wound healing for the tissue repair with the least complications. In this study, we aimed to isolate, purify and quantitate tannins and phenolic compounds from exocarp and pulp of fruits of Iranian pomegranate cultivars. Our findings demonstrate that the highest amount of tannin extracts from ethanol extract of the black peel exocarp was 201.76 ± 1.93. The highest amount of flavonoids from the ethanol extract of Sweet Alac exocarp was119.69 ± 1.02 as well as antioxidant compounds activity in the exocarp and pulp showed that the highest activity is in the ethanol extract of the black peel was 95.65 ± 3.1. The total phenolic activity indicated that the Sour white peel ethanol extract has the highest phenolic activity 327.05 ± 863. Our data suggest that the ethanol extract of pomegranate exocarp has the higher amounts of tannins and flavonoids, compounds that are known to be beneficial for wound healing. Taken together, these data suggest that compounds isolated from Iranian pomegranate cultivars offer new options for managements of wound healing.</p> 2019-01-22T08:40:43+01:00 ##submission.copyrightStatement## https://pagepressjournals.org/index.php/bam/article/view/7873 Comparison of intradermal Dexmedmotidine and subcutaneous Ketamine for post-surgical pain management in patients with abdominal hysterectomy 2019-03-25T17:24:45+01:00 Alireza Kamali alikamaliir@yahoo.com Zahra Zarepour zahar_zarepor@yahoo.com Maryam Shokrpour Maryam_shokrpour@yahoo.com Shirin Pazuki shirin_pazoki@yahoo.com <p>Hysterectomy after cesarean section is the second most commonly used surgery for women in the United States. One of the most common problem after hysterectomy is pain. We decided to compare the effects of dexmedmotidine or ketamine on pain in patients by a double blind randomized clinical trial on 126 female candidates for abdominal hysterectomy in three groups of 42 persons referred to Taleghani hospital in Arak. For the first group, 50 micrograms of intradermal dexmedmotidine were injected, while in the second group, patients were injected with 100 mg of subcutaneous ketamine and the third group received 5 cc normal saline. Data were next analyzed by SPSS version 19. The mean age and body mass index of the patients were not significantly different in the three groups. The mean scores of pain during recovery of patients in ketamine, dexmedmotidine and placebo groups were 4.2±0.77, 2.6±0.89 and 1.3±0.87, respectively (p = 0.001). Scores of pain in patients at 4 and 8 hours after surgery showed also significant differences. In conclusion, ketamine and dexmedmotidine significantly reduce the severity of pain, but ketamine has a lower effect.</p> 2019-01-11T13:54:23+01:00 ##submission.copyrightStatement## https://pagepressjournals.org/index.php/bam/article/view/7945 Peripheral axotomy-induced changes of motor function and histological structure of spinal anterior horn 2019-03-25T17:24:44+01:00 Amir Raoofi amirrezaraoofi@yahoo.com Mohammad Amin Abdollahifar m_amin58@yahoo.com Abbas Aliaghaei aghaei60@gmail.com Abbas Piryaei piryae@sbmu.ac.ir Fatemeh Hejazi mahsa.hejazi@gmail.com Ensieh Sajadi e.sajadi111@gmail.com Ali Rashidiani-Rashidabadi ali.rashidian88@gmail.com Yousef Sadeghi dr.ysadeghi@yahoo.com <p>The aim of this study was to evaluate changes of both peripheral motor function and histology of spinal anterior horn in adult rats after unilateral sciatectomy. Ten adult healthy rats served as control group, while in the ten rat experimental group the right sciatic nerve was severed. We followed-up nerve motor function using a sciatic function index and electromyography activity of the gastrocnemious muscle. The rats of the experimental group presented the expected gross locomotor deficit and leg muscle atrophy. At 12 weeks post sciatectomy, L4 and L5 spinal cord segments were removed from the twenty rats and were analysed by istological stereological methods. In the axotomized animals volume of the anterior horn and its content of motor neurons decreased, while the content of astrocytes increased (p &lt; 0.05). Thus, in adult rats, beside the obvious peripheral nerve disfuction, the sciatic nerve axotomy have severe consequences on the soma of the injured motor neurons in the spinal anterior horn. All these quantitative analyses may be usefull to quantify changes occurring in adult animals after axotomy and eventual management to modify the final outcomes in peripheral nerve disorders.</p> 2019-01-17T09:08:57+01:00 ##submission.copyrightStatement## https://pagepressjournals.org/index.php/bam/article/view/8105 2019Spring PaduaMuscleDays: Translational Myology and Mobility Medicine 2019-03-25T17:24:42+01:00 Ugo Carraro ugo.carraro@unipd.it <p>A half-century tradition of skeletal muscles studies, started with a research on fever, is continuing under the auspices of the Interdepartmental Research Centre of Myology (CIR-Myo), Department of Biomedical Sciences, University of Padova, Italy, the AandC M-C Foundation for Translational Myology, Padova, Italy and the European Journal of Translational Myology (EJTM). This year an EJTM Special will be dedicated to Muscle Fascia, an under looked topic, which merits more attention. Furthermore, this year the 2019SpringPaduaMuscleDays: Translational Myology and Mobility Medicine, an International Conference, was held March 28-30, 2019 in Euganei Hills and Padova (Italy). The abstracts of the 2019SpPMD, that are reported in the Myology News of EJTM 29 (1), 2019, are excellent examples of translational research. Their excellent contents are at the level needed for approval by Ethical Committees, International Granting Agencies, and Editors of international journals, thanks to the high scientific profiles of researchers and clinicians who are eager to present their results at the PaduaMuscleDays.</p> 2019-02-21T09:41:17+01:00 ##submission.copyrightStatement## https://pagepressjournals.org/index.php/bam/article/view/8155 Collection of the Abstracts of the 2019Sp PMD: Translational Myology and Mobility Medicine 2019-03-25T17:24:39+01:00 Ugo Carraro ugo.carraro@unipd.it <p>The Interdepartmental Research Centre of Myology (CIR-Myo), Department of Biomedical Sciences, University of Padova, Italy and the AandC M-C Foundation for Translational Myology, Padova, Italy organized with the scientific support of Helmut Kern, Jonathan C. Jarvis, Viviana Moresi, Marco Narici, Feliciano Protasi, Marco Sandri and Ugo Carraro, the 2019SpringPaduaMuscleDays: Translational Myology and Mobility Medicine, an International Conference held March 28-30, 2019 in Euganei Hills and Padova (Italy). Presentations and discussions of the Three Physiology Lectures and of the seven Sessions (I: Spinal Cord Neuromodulation and h-bFES in SC; II: Muscle epigenetics in aging and myopathies; III: Experimental approaches in animal models; IV: Face and Voice Rejuvenation; V: Muscle Imaging; VI: Official Meeting of the EU Center of Active Aging; VII: Early Rehabilitation after knee and hip replacement) were at very high levels. This was true in the past and will be true in future events thanks to researchers and clinicians who were and are eager to attend the PaduaMuscleDays.</p> 2019-03-11T10:23:12+01:00 ##submission.copyrightStatement##