European Journal of Translational Myology 2019-01-20T17:20:03+01:00 Francesca Baccino Open Journal Systems <p>The <strong>European Journal of Translational Myology</strong> (formerly known as <em>Basic and Applied Myology</em>) is the European reference forum for Translational Myology. The <strong>European Journal of Translational Myology</strong>&nbsp;is a multifaceted journal studying myology from various perspectives: basic, cellular and molecular, genetic, clinical, and translational proper.</p> Comparison of Intradermal Dexmedmotidine and Subcutaneous Ketamine for Post-surgical Pain Management in Patients with Abdominal Hysterectomy 2019-01-20T17:20:03+01:00 Alireza Kamali Maryam Shokrpour Zahra Zarepour Shirin Pazuki <p>Hysterectomy after cesarean section is the second most commonly used surgery for women in the United States. One of the most common problem after hysterectomy is pain. We decided to compare the effects of dexmedmotidine or ketamine on pain in patients by a double blind randomized clinical trial on 126 female candidates for abdominal hysterectomy in three groups of 42 persons referred to Taleghani hospital in Arak. For the first group, 50 micrograms of intradermal dexmedmotidine were injected, while in the second group, patients were injected with 100 mg of subcutaneous ketamine and the third group received 5 cc normal saline. Data were next analyzed by SPSS version 19. The mean age and body mass index of the patients were not significantly different in the three groups. The mean scores of pain during recovery of patients in ketamine, dexmedmotidine and placebo groups were 4.2±0.77, 2.6±0.89 and 1.3±0.87, respectively (p = 0.001). Scores of pain in patients at 4 and 8 hours after surgery showed also significant differences. In conclusion, ketamine and dexmedmotidine significantly reduce the severity of pain, but ketamine has a lower effect.</p> 2019-01-11T13:54:23+01:00 ##submission.copyrightStatement## Peripheral axotomy-induced changes of motor function and histological structure of spinal anterior horn 2019-01-20T17:20:02+01:00 Amir Raoofi Mohammad Amin Abdollahifar Abbas Aliaghaei Abbas Piryaei Fatemeh Hejazi Ensieh Sajadi Ali Rashidiani-Rashidabadi Yousef Sadeghi <p>The aim of this study was to evaluate changes of both peripheral motor function and histology of spinal anterior horn in adult rats after unilateral sciatectomy. Ten adult healthy rats served as control group, while in the ten rat experimental group the right sciatic nerve was severed. We followed-up nerve motor function using a sciatic function index and electromyography activity of the gastrocnemious muscle. The rats of the experimental group presented the expected gross locomotor deficit and leg muscle atrophy. At 12 weeks post sciatectomy, L4 and L5 spinal cord segments were removed from the twenty rats and were analysed by istological stereological methods. In the axotomized animals volume of the anterior horn and its content of motor neurons decreased, while the content of astrocytes increased (p&lt;0.05). Thus, in adult rats, beside the obvious peripheral nerve disfuction, the sciatic nerve axotomy have severe consequences on the soma of the injured motor neurons in the spinal anterior horn. All these quantitative analyses may be usefull to quantify changes occurring in adult animals after axotomy and eventual management to modify the final outcomes in peripheral nerve disorders.</p> 2019-01-17T09:08:57+01:00 ##submission.copyrightStatement##