European Journal of Translational Myology 2019-05-20T17:31:58+02:00 Francesca Baccino Open Journal Systems <p>The <strong>European Journal of Translational Myology</strong> (formerly known as <em>Basic and Applied Myology</em>) is the European reference forum for Translational Myology. The <strong>European Journal of Translational Myology</strong>&nbsp;is a multifaceted journal studying myology from various perspectives: basic, cellular and molecular, genetic, clinical, and translational proper.</p> Investigation into Breast Cancer and Partial Breast Reconstruction: A Review 2019-05-20T17:31:52+02:00 Mohammad Reza Ebadi Maryam Kazemi Aghdam Zeinab Safarpour Lima Ladan Younesi <p>Growing increasingly in South America, Africa and Asia, breast cancer is known as the dominant type of cancer in women. Different treatments are available for breast cancer, among which surgery is the most widely used, but researchers are trying to develop new strategies. One of the most prominent surgical methods is referred to as oncoplastic surgery, that helps to remove segments of malignant breast tissue. This type of surgery aims to obtain vast surgical margins, while the remaining tissue is rearranged so that the better cosmetic outcome is obtained. This review will investigate the breast cancer and then discuss partial breast reconstruction. Before outlining the procedures, the different types of partial breast reconstruction will be discussed. Finally, advantages and disadvantages will be outlined. MEDLINE database was used to conduct the search. The main terms used were ‘Conservation Breast Surgery Reconstruction’ AND ‘Oncoplastic Surgery’, ‘Partial Mastectomy Reconstruction’ AND ‘Conservative Breast Surgery Reconstruction’, ‘oncoplastic’ [All Fields], ‘breast’ AND ‘surgery’ OR ‘surgery’ operative’, ‘oncoplastic’ (‘breast’)’. The bibliographies of relevant papers were manually searched up to October 2018, but more recent voices are also included.</p> 2019-05-16T15:55:45+02:00 ##submission.copyrightStatement## A proposed role for non-junctional transverse tubules in skeletal muscle as flexible segments allowing expansion of the transverse network 2019-05-20T17:31:53+02:00 Manuela Lavorato Ramesh Iyer Clara Franzini-Armstrong <p>Using a variety of technical approaches, we have detected the presence of continuous triads that cover the entire length of T tubules in the main white body muscles of several small fish. This is in contrast to the discontinuous association of SR with T tubules in the red muscles from the same fish as well as in all other previously described muscles in a large variety of skeletal muscles. We suggest that continuous triads are permissible only in muscle fibers that are not normally subject to significant changes in sarcomere length during normal <em>in vivo</em> activity, as is the case for white muscles in the trunk of fish.</p> 2019-05-16T14:17:44+02:00 ##submission.copyrightStatement## Relevance of lactate level detection in migrane and fibromyalgia 2019-05-20T17:31:56+02:00 Patrizia Proia Alessandra Amato Valentina Contrò Alessandra Lo Monaco Jessica Brusa Filippo Brighina Giuseppe Messina <p>The aim of this study was to determine the blood lactate levels in healthy and pathological subjects, particularly with migraine and fibromyalgia. Moreover we investigated the possible correlation between lactate concentration, postural stability and balance disorders; the composition of the groups were: migraine (n = 25; age 49.7 ± 12.5), fibromyalgia (n = 10; age 43.7 ± 21.2), control group (n = 16 age 28.52 ± 2.4). The results showed that patients with fibromyalgia (FG) had higher lactate levels compared to migraine (MG) and control group (CG) (mean ± sd: FG = 1.78 ± 0.9 mmol/L; MG = 1.45±1 mmol/L; CG = 0,85 ± 0,07 mmol/L). The same situation was highlighted about the sway path length with eyes closed (FG = 518 ± 195 mm; MG = 465 ± 165 mm; CG = 405 ± 94,72 mm) and with eyes open (FG = 430 ± 220 mm; MG = 411 ± 143 mm; CG = 389 ± 107 mm). This can be explained by the fact that energy-intensive postural strategies must be used to optimize both static and dynamic coordination, in particular with repeated contractions of tonic oxidative muscle cells responsible for postural control.</p> 2019-05-09T09:40:59+02:00 ##submission.copyrightStatement## Urinary antigene and PCR can both be used to detect Legionella pneumophila in children's hospital-acquired pneumonia 2019-05-20T17:31:58+02:00 Sayed-Yousef Mojtahedi Aliakbar Rahbarimanesh Samileh Noorbakhsh Hossein Shokri Saeedreza Jamali-Moghadam-Siyahkali Anahita Izadi <p><em>Legionella pneumophila</em> is the causative agent of more than 95% cases of severe <em>Legionella pneumonia.</em> Nosocomial pneumonias in different hospital wards is an important medical and pharmaceutical concern. This study aimed to detect <em>Legionella</em> with two methods: polymerase chain reaction [PCR] and detection of urine antigenic test [UAT] in patients suffering from nosocomial pneumonia admitted to pediatric intensive care unit [PICU] of children hospitals. This study was conducted in PICU wards of Rasool Akram and Bahrami children hospitals, Tehran, Iran during 2013 - 2014. In patients diagnosed with hospital-acquired pneumonia, intratracheal secretion samples for PCR and urine sample for urinary antigen test [UTA] were taken. Simultaneously, PCR and urinary antigen test were conducted using commercial kits. The results of urinary antigen test and PCR were analyzed by SPSS v.19 for statistical comparison. In this study, 96 patients aging 2.77 years on average with two age peaks of less than 1 year and 7-8 year were enrolled. More than half of the patients were under 1 year old. The most common underlying diseases were seizure, Acute Lymphoblastic Lymphoma, Down syndrome and metabolic syndromes. The positivity rate of <em>Legionella</em> urinary antigen test was 16.7% and positivity rate of PCR test was 19.8%. There were no significant associations between the results obtained by both assays with age, gender or underlying diseases. In conclusion, PCR is a better detection method for Legionella infection than urinary antigen test, but the difference between the two methods was not significant.</p> 2019-05-07T12:07:56+02:00 ##submission.copyrightStatement## Natural host preferences of parasitoid wasps (Hymenoptera: Pteromalidae) on synanthropic flies 2019-05-20T17:31:57+02:00 Mehdi Khoobdel Hossein Sobati Omid Dehghan Kamran Akbarzadeh Ehsan Radi <p>Synanthropic flies are members of order Diptera and considered as medical and veterinary pests. In this study, parasitoid wasps were determined and their natural host preferences in order to select a suitable agent for biological control of flies. The pupae of three species of flies; <em>Musca domestica</em>, <em>Lucilia sericata</em> and <em>Sarcophaga haemorrhoidalis</em> were used as hosts for natural parasitoids. For this issue, as much as 50 pupae of each fly species put in three separate dishes with covered top by a net. These dishes were placed in the field to attract parasitoid wasps. The most parasitic rate was related to <em>N. vitripennis</em> (%17.2). Host preferences of <em>N. vitripennis</em> on <em>M. domestica</em> pupae were higher than observed parasitism on <em>L. sericata</em> and <em>S. haemorrhoidalis</em>. The emerging rate of two parasitoids; <em>P. vindemmiae</em> and <em>S. nigroaenea</em> were one per host pupae. According to the result, <em>N. vitripennis</em> can be an appropriate candidate for use as natural enemy which expected to be effective in controlling various species of synanthropic flies. Therefore, <em>S. nigroaenea</em> was more suitable to biological control of housefly populations.</p> 2019-05-07T12:18:12+02:00 ##submission.copyrightStatement## Comparison of sublingual Buprenorphine and intravenous Morphine in reducing bone metastases associated pain in cancer patients 2019-05-20T17:31:54+02:00 Seyed Mohammad Jamalian Mohammad Sotodeh Fathollah Mohaghegh <p>Bone metastases is one of the most common causes of pain in cancer patients and have a significant effect on their quality of life. The most common symptom of bone metastases is pain that gradually develops. Morphine is used to relieve pain in these patients, poorly accepted by patients due to its adverse events. Therefore, the current study was aimed to compare the effect of sublingual buprenorphine, with certainly lower complications with morphine. Fourth patients were divided into 2 groups. In group A, metastatic cancer patients received 2.5 mg of intravenous (IV) morphine. Furthermore, in group B, sublingual tablet of buprenorphine (one-fourth of a 500 μg tablet) was administered sublingually. Pain was measured 15, 30, and 45 minutes after the onset of pain using visual analog scale (VAS) Ruler. Based on the obtained data, two groups A and B were compared using SPSS 23 software. There was a significant difference between the patient's pain intensity after 15 and 30 minutes from the onset of pain in both groups. Due to the fact that the duration of the effect of morphine is 3-4 hours and the duration of the effect of sublingual buprenorphine is 6-8 hours, therefore, morphine showed fast acting forms of opioids (P= 0.001). The required dose level on the first day was similar in both groups and there was no statistically significant difference between the two groups. While on the second and third days, the median dose in group A (morphine) was greater than group B (buprenorphine), indicating prolonged duration of action for buprenorphine compared with morphine, thus requiring a lower subsequent doses. The results of this study suggested that sublingual buprenorphine is a higher effective drug compared to intravenous morphine during after operation. With regard to easy and painless administration, it seems that its use can be useful in controlling pain due to bone metastases in cancer patients.</p> 2019-05-13T08:44:53+02:00 ##submission.copyrightStatement##