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Biology of muscle atrophy and of its recovery by FES in aging and mobility impairments: roots and by-products

Ugo Carraro, Helmut Kern, Paolo Gava, Christian Hofer, Stefan Loefler, Paolo Gargiulo, Simone Mosole, Sandra Zampieri, Valerio Gobbo, Barbara Ravara, Francesco Piccione, Andrea Marcante, Alfonc Baba, Sheila Schils, Amber Pond, Francesco Gava
  • Ugo Carraro
    IRRCS Fondazione Ospedale San Camillo, Venezia; Laboratory of Translational Myology of the Interdepartmental Research Center of Myology, Department of Biomedical Science, University of Padova, Italy
  • Helmut Kern
    Institute of Physical Medicine and Rehabilitation, Wilhelminenspital, Vienna; Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Vienna, Austria
  • Paolo Gava
    Laboratory of Translational Myology of the Interdepartmental Research Center of Myology, Department of Biomedical Science, University of Padova, Italy
  • Christian Hofer
    Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Vienna, Austria
  • Stefan Loefler
    Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Vienna, Austria
  • Paolo Gargiulo
    Institute for Biomedical and Neural Engineering, Reykjavík; Landspítali, Reykjavík, Iceland
  • Simone Mosole
    Laboratory of Translational Myology of the Interdepartmental Research Center of Myology, Department of Biomedical Science, University of Padova, Italy; Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Vienna, Austria
  • Sandra Zampieri
    Laboratory of Translational Myology of the Interdepartmental Research Center of Myology, Department of Biomedical Science, University of Padova, Italy; Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Vienna, Austria
  • Valerio Gobbo
    C.N.R. Institute of Neuroscience, Department of Biomedical Science, University of Padova, Italy
  • Barbara Ravara
    Laboratory of Translational Myology of the Interdepartmental Research Center of Myology, Department of Biomedical Science, University of Padova, Italy; Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Vienna, Austria
  • Francesco Piccione
    IRRCS Fondazione Ospedale San Camillo, Venezia, Italy
  • Andrea Marcante
    IRRCS Fondazione Ospedale San Camillo, Venezia, Italy
  • Alfonc Baba
    IRRCS Fondazione Ospedale San Camillo, Venezia, Italy
  • Sheila Schils
    EquiNew, 8139 900th Street, River Falls, WI, United States
  • Amber Pond
    Anatomy Department, Southern Illinois University, School of Medicine, Carbondale, IL, United States
  • Francesco Gava
    Laboratory of Translational Myology of the Interdepartmental Research Center of Myology, Department of Biomedical Science, University of Padova, Italy; Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Vienna, Austria | francescospa@alice.it

Abstract

There is something in our genome that dictates life expectancy and there is nothing that can be done to avoid this; indeed, there is not yet any record of a person who has cheated death. Our physical prowess can vacillate substantially in our lifetime according to our activity levels and nutritional status and we may fight aging, but we will inevitably lose. We have presented strong evidence that the atrophy which accompanies aging is to some extent caused by loss of innervation. We compared muscle biopsies of sedentary seniors to those of life long active seniors, and show that these groups indeed have a different distribution of muscle fiber diameter and fiber type. The senior sportsmen have many more slow fiber-type groupings than the sedentary people which provides strong evidence of denervation-reinnervation events in muscle fibers. It appears that activity maintains the motoneurons and the muscle fibers. Premature or accelerated aging of muscle may occur as the result of many chronic diseases. One extreme case is provided by irreversible damage of the Conus and Cauda Equina, a spinal cord injury (SCI) sequela in which the human leg muscles may be completely and permanently disconnected from the nervous system with the almost complete disappearance of muscle fibers within 3-5 years from SCI. In cases of this extreme example of muscle degeneration, we have used 2D Muscle Color CT to gather data supporting the idea that electrical stimulation of denervated muscles can retain and even regain muscle. We show here that, if people are compliant, atrophy can be reversed. A further example of activity-related muscle adaptation is provided by the fact that mitochondrial distribution and density are significantly changed by functional electrical stimulation in horse muscle biopsies relative to those not receiving treatment. All together, the data indicate that FES is a good way to modify behaviors of muscle fibers by increasing the contraction load per day. Indeed, it should be possible to defer the muscle decline that occurs in aging people and in those who have become unable to participate in physical activities. Thus, FES should be considered for use in rehabilitation centers, nursing facilities and in critical care units when patients are completely inactive even for short periods of time.

Keywords

Aging decay; Muscle denervation/reinnervation; H-b FES-induced muscle recovery; Subsarcolemmal mitochondria; Equine muscle spasm

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Submitted: 2015-05-16 10:27:42
Published: 2015-08-25 00:00:00
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Copyright (c) 2015 Ugo Carraro, Helmut Kern, Paolo Gava, Christian Hofer, Stefan Loefler, Paolo Gargiulo, Simone Mosole, Sandra Zampieri, Valerio Gobbo, Barbara Ravara, Francesco Piccione, Andrea Marcante, Alfonc Baba, Sheila Schils, Amber Pond, Francesco Gava

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