Correlation between polymorphism of TYMS gene and toxicity response to treatment with 5-fluoruracil and capecitabine


https://doi.org/10.4081/ejtm.2020.8970
Vol. 30 No. 3 (2020)
Submitted: 19 March 2020
Accepted: 13 May 2020
Published: 4 August 2020
Cancer, genetics, thymidylate synthase, polymorphisms, toxicity
Abstract Views: 877
PDF: 499
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Authors

  • Stefano Vitello Regional Hospital S. Elia, Caltanissetta, Italy.
  • Italia Di Liegro Department of Experimental Biomedicine and Clinical Neurosciences (BIONEC), University of Palermo, Palermo, Italy.
  • Maria Rita Ricciardi Regional Hospital S. Elia, Caltanissetta, Italy.
  • Chiara Verga Regional Hospital S. Elia, Caltanissetta, Italy.
  • Alessandra Amato Department of Psychological, Pedagogical and Educational Sciences, Sport and Exercise Sciences Research Unit, University of Palermo, Palermo, Italy.
  • Gabriella Schiera Department of Biological Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy.
  • Carlo Di Liegro Department of Biological Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy.
  • Giuseppe Messina
    giuseppe.messina17@unipa.it
    Department of Psychological, Pedagogical and Educational Sciences, Sport and Exercise Sciences Research Unit, University of Palermo, Palermo, Italy.
  • Patrizia Proia Department of Psychological, Pedagogical and Educational Sciences, Sport and Exercise Sciences Research Unit, University of Palermo, Palermo, Italy.

Tumorigenesis is a multiphasic process in which genetic alterations guide the progressive transformation in cancer cells1. In order to evaluate the possible correlation between some gene variants and the risk of the toxicity development onset, two of the polymorphisms of the thymidylate synthase (TYMS), rs34743033 (2R/3R) and rs16430 (DEL/INS) were investigated. We enrolled in our study 47 patients from the Hospital of Sicily. Our preliminary findings suggest that there could be a linkage between the genotypes discussed and the development of the toxicity following the chemotherapy treatment. These results need to be confirmed by further studies, however this short paper offers some initial insight into the relationships between genetic background and the better outcome for patients.


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Vitello, S., Di Liegro, I., Ricciardi, M. R., Verga, C., Amato, A., Schiera, G., Di Liegro, C., Messina, G., & Proia, P. (2020). Correlation between polymorphism of TYMS gene and toxicity response to treatment with 5-fluoruracil and capecitabine. European Journal of Translational Myology, 30(3). https://doi.org/10.4081/ejtm.2020.8970

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