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Neurohypophyseal hormones and skeletal muscle: a tale of two faces

Authors

Alexandra Benoni
https://orcid.org/0000-0003-3283-8660
Histology and Embryology Section, Dept. AHFOS, Sapienza University of Rome, France.
Alessandra Renzini
https://orcid.org/0000-0002-4265-7188
Histology and Embryology Section, Dept. AHFOS, Sapienza University of Rome, Italy.
Giorgia Cavioli
Histology and Embryology Section, Dept. AHFOS, Sapienza University of Rome, Italy.
Sergio Adamo
sergio.adamo@uniroma1.it
http://orcid.org/0000-0002-1409-0452
Histology and Embryology Section, Dept. AHFOS, Sapienza University of Rome, Italy.

The neurohypophyseal hormones vasopressin and oxytocin were invested, in recent years, with novel functions upon striated muscle, regulating its differentiation, trophism, and homeostasis. Recent studies highlight that these hormones not only target skeletal muscle but represent novel myokines. We discuss the possibility of exploiting the muscle hypertrophying activity of oxytocin to revert muscle atrophy, including cancer cachexia muscle wasting. Furthermore, the role of oxytocin in cardiac homeostasis and the possible role of cardiac atrophy as a concause of death in cachectic patients is discussed.

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Supporting Agencies

Sapienza University

How to Cite

Benoni, A., Renzini, A., Cavioli, G., & Adamo, S. (2020). Neurohypophyseal hormones and skeletal muscle: a tale of two faces. European Journal of Translational Myology, 30(1), 53–57. https://doi.org/10.4081/ejtm.2019.8899

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