Cover Image

Of faeces and sweat. How much a mouse is willing to run: having a hard time measuring spontaneous physical activity in different mouse sub-strains

Dario Coletti, Sergio Adamo, Viviana Moresi
  • Dario Coletti http://orcid.org/0000-0001-7373-1953
    Sorbonne Universités, UPMC Univ Paris 06 (CNRS, UMR 8256, INSERM ERL U1164), Institut Biologie Paris-Seine, Paris, France; Dept. of Anatomy, Histology, Forensic Medicine & Orthopedics, School of Medicine Sapienza University of Rome; Interuniversity Institute of Myology, Italy | dario.coletti@uniroma1.it
  • Sergio Adamo
    Dept. of Anatomy, Histology, Forensic Medicine & Orthopedics, School of Medicine Sapienza University of Rome, Italy; Interuniversity Institute of Myology, Italy
  • Viviana Moresi
    Dept. of Anatomy, Histology, Forensic Medicine & Orthopedics, School of Medicine Sapienza University of Rome, Italy; Interuniversity Institute of Myology, Italy

Abstract

Physical activity has multiple beneficial effects in the physiology and pathology of the organism. In particular, we and other groups have shown that running counteracts cancer cachexia in both humans and rodents. The latter are prone to exercise in wheel-equipped cages even at advanced stages of cachexia. However, when we wanted to replicate the experimental model routinely used at the University of Rome in a different laboratory (i.e. at Paris 6 University), we had to struggle with puzzling results due to unpredicted mouse behavior. Here we report the experience and offer the explanation underlying these apparently irreproducible results. The original data are currently used for teaching purposes in undergraduate student classes of biological sciences.

Keywords

BALB/c mice; Murine sub-strains; Inbred mouse strains; Running behavior; Endurance exercise

Full Text:

PDF
HTML
Submitted: 2016-12-16 16:10:39
Published: 2017-03-27 13:53:49
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
392

Views:
PDF
302
HTML
143

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2017 Dario Coletti, Sergio Adamo, Viviana Moresi

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185     •     Privacy