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Stem cells and tissue niche: two faces of the same coin of muscle regeneration

Bianca Maria Scicchitano, Gigliola Sica, Antonio Musarò
  • Bianca Maria Scicchitano
    Institute of Histology and Embryology, Catholic University School of Medicine, Rome, Italy
  • Gigliola Sica
    Institute of Histology and Embryology, Catholic University School of Medicine, Rome, Italy


Capacity of adult muscle to regenerate in response to injury stimuli represents an important homeostatic process. Regeneration is a highly coordinated program that partially recapitulates the embryonic developmental program. However, muscle regeneration is severely compromised in several pathological conditions. It is likely that the restricted tissue repair program under pathological conditions is due to either progressive loss of stem cell populations or to missing signals that limit the damaged tissues to efficiently activate a regenerative program. It is therefore plausible that loss of control over these cell fates might lead to a pathological cell transdifferentiation, limiting the ability of a pathological muscle to sustain an efficient regenerative process. The critical role of microenvironment on stem cells activity and muscle regeneration is discussed.


Muscle regeneration; Tissue niche; Muscle pathologies; Satellite cells; IGF-1

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Submitted: 2016-07-04 12:16:05
Published: 2016-12-15 00:00:00
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Copyright (c) 2016 Bianca Maria Scicchitano, Antonio Musaro

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