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Physical activity counteracts tumor cell growth in colon carcinoma C26-injected muscles: an interim report

Charlotte Hiroux, Tijs Vandoorne, Katrien Koppo, Stefan De Smet, Peter Hespel, Emanuele Berardi
  • Charlotte Hiroux
    Exercise Physiology Research Group, Department of Kinesiology, KU Leuven, Belgium
  • Tijs Vandoorne
    Exercise Physiology Research Group, Department of Kinesiology, KU Leuven, Belgium
  • Katrien Koppo
    Exercise Physiology Research Group, Department of Kinesiology, KU Leuven, Belgium
  • Stefan De Smet
    Exercise Physiology Research Group, Department of Kinesiology, KU Leuven, Belgium
  • Peter Hespel
    Exercise Physiology Research Group, Department of Kinesiology, KU Leuven, Belgium

Abstract

Skeletal muscle tissue is a rare site of tumor metastasis but is the main target of the degenerative processes occurring in cancer-associated cachexia syndrome. Beneficial effects of physical activity in counteracting cancer-related muscle wasting have been described in the last decades. Recently it has been shown that, in tumor xeno-transplanted mouse models, physical activity is able to directly affect tumor growth by modulating inflammatory responses in the tumor mass microenvironment. Here, we investigated the effect of physical activity on tumor cell growth in colon carcinoma C26 cells injected tibialis anterior muscles of BALB/c mice. Histological analyses revealed that 4 days of voluntary wheel running significantly counteracts tumor cell growth in C26-injected muscles compared to the non-injected sedentary controls. Since striated skeletal muscle tissue is the site of voluntary contraction, our results confirm that physical activity can also directly counteract tumor cell growth in a metabolically active tissue that is usually not a target for metastasis.

Keywords

Cancer cachexia; Colon carcinoma C26 cells; Tumor cell growth; Muscle inflammation; Voluntary running

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Submitted: 2016-04-28 16:11:55
Published: 2016-06-13 16:48:18
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Copyright (c) 2016 Charlotte Hiroux, Tijs Vandoorne, Katrien Koppo, Stefan De Smet, Peter Hespel, Emanuele Berardi

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