https://doi.org/10.4081/ejtm.2023.11557

Combined effect of medical therapy and rehabilitation in Chronic Ataxic Neuropathy with anti-Disialosyl IgM Antibodies (CANDA): a case report

Vol. 33 No. 3 (2023)
Submitted: 30 June 2023
Accepted: 17 July 2023
Published: 31 July 2023
chronic ataxic neuropathy, CANDA, anti-disialosyl antibodies, rehabilitation, muscle exercise
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Authors

Giulio Balestro
https://orcid.org/0009-0008-7271-9352
Unit of Neurorehabilitation, Department of Neurosciences, Biomedicine and Movement Sciences, University Hospital of Verona, University of Verona, Verona, Italy.
Alessandro Picelli
Unit of Neurorehabilitation, Department of Neurosciences, Biomedicine and Movement Sciences, University Hospital of Verona, University of Verona, Verona, Italy.
Luca Ortolani
https://orcid.org/0009-0009-2412-6410
U.O.C. Recovery and Functional Rehabilitation – Lonigo, Ulss8 Berica, Italy.
Andrea Marcante
andrea.marcante@aulss8.veneto.it
U.O.C. Recovery and Functional Rehabilitation – Lonigo, Ulss8 Berica, Italy.

Chronic Ataxic Neuropathy with anti-Disialosyl IgM Antibodies (CANDA) is a rare form of immune-mediated sensory ataxic neuropathy. We describe the case of a 45-year-old man, who was diagnosed with CANDA in October 2018. Since then, he has been treated with monthly courses of intravenous immunoglobulin administration (IV Ig) and, in October 2022, he underwent plasmapheresis, reporting a sudden worsening of clinical and motor picture. After a new IV Ig cycle admission, the patient was hospitalized to perform intensive rehabilitation, involving two individual sessions per day (90 minutes each) for 5 days a week. During hospitalization it was registered a relevant improvement in the muscle strength of the lower limbs (LLs). Furthermore, progressive improvements were recorded both in patient's motor performance and in his level of autonomy in activities of daily living. These results had a positive impact on his quality of life and made it possible to reduce the frequency of IV Ig treatments. This is the first case in literature reporting the combined effect of rehabilitation treatment and medical therapy in CANDA neuropathy.

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How to Cite

Balestro, G., Picelli, A., Ortolani, L., & Marcante, A. (2023). Combined effect of medical therapy and rehabilitation in Chronic Ataxic Neuropathy with anti-Disialosyl IgM Antibodies (CANDA): a case report. European Journal of Translational Myology, 33(3). https://doi.org/10.4081/ejtm.2023.11557
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