https://doi.org/10.4081/ejtm.2021.10200

Length-dependent changes of lower limb muscle morphology in Chronic Inflammatory Demyelinating Polyneuropathy assessed with magnetic resonance imaging

Vol. 31 No. 4 (2021)
Submitted: 12 October 2021
Accepted: 11 November 2021
Published: 18 November 2021
Chronic inflammatory demyelinating polyneuropathy, CIDP, muscle quality, muscle composition, MRI
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Authors

Jacob Fanous
jfanous3@uwo.ca
School of Kinesiology, The University of Western Ontario, London, ON, Canada.
Alexander M. Zero
https://orcid.org/0000-0001-7962-4147
School of Kinesiology, The University of Western Ontario, London, ON, Canada.
Kevin J. Gilmore
Department of Surgery, University of Toronto, Toronto, ON, Canada.
Timothy J. Doherty
Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada ; Department of Physical Medicine and Rehabilitation, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada.
Charles L. Rice
School of Kinesiology, The University of Western Ontario, London, ON, Canada; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada.

The objective of the present study was to assess muscle quantity of the thigh and leg in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) compared to age and sex matched controls in exploring length-dependent changes of innervated muscles. In five people with CIDP and seven controls, magnetic resonance imaging was used to assess muscle morphology of the four parts of the quadriceps and medial hamstring muscles. Findings were compared to the triceps surae from a subset of participants. The CIDP group had less contractile tissue in the quadriceps (11.5%, P<0.05), hamstrings (15.6%, P<0.05) and triceps surae (35.9%, P<0.05) compared to controls. Additionally, CIDP had less contractile tissue (18.7%) in the triceps surae compared to the hamstrings (P<0.05). Muscle quantity in the quadriceps and hamstrings in CIDP was less than controls, but differences were greater for the distal triceps surae. These findings support a length-dependent affect of CIDP on limb musculature composition.

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How to Cite

Fanous, J., Zero, A. M., Gilmore, K. J., Doherty, T. J., & Rice, C. L. (2021). Length-dependent changes of lower limb muscle morphology in Chronic Inflammatory Demyelinating Polyneuropathy assessed with magnetic resonance imaging. European Journal of Translational Myology, 31(4). https://doi.org/10.4081/ejtm.2021.10200

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