Tavares-da-Silva, Edgar, Urology and Transplantation Department, Coimbra Hospital and University Centre, Coimbra; Institute of Biophysics, Faculty of Medicine, University of Coimbra, Coimbra; Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO) Faculty of Medicine University of Coimbra, Portugal