TY - JOUR AU - Perletti, Gianpaolo AU - Magri, Vittorio AU - Vral, Anne AU - Stamatiou, Konstantinos AU - Trinchieri, Alberto PY - 2019/10/02 Y2 - 2024/03/29 TI - Green tea catechins for chemoprevention of prostate cancer in patients with histologically-proven HG-PIN or ASAP. Concise review and meta-analysis JF - Archivio Italiano di Urologia e Andrologia JA - Arch Ital Urol Androl VL - 91 IS - 3 SE - Original Papers - Prostate DO - 10.4081/aiua.2019.3.153 UR - https://www.pagepressjournals.org/aiua/article/view/aiua.2019.3.153 SP - AB - <p>A focused, single outcome meta-analysis on the protective role of extracts of green tea catechins against prostate cancer. Randomized, placebo-controlled studies enrolling patients with a histologically confirmed diagnosis of high-grade Prostate Intraepithelial Neoplasia or Atypical Small Acinar proliferation but no prostate cancer were included. Meta-analysis for binary data was performed using Mantel-Haenszel statistics, using a random-effects model. Heterogeneity was investigated by calculating the I2. Four studies matched the inclusion criteria for the review. The pooled population was 223 patients; 114 and 109 patients were randomized to catechin and placebo groups, respectively. Nine cases of prstate cancer occurred in the catechin arm (7.9%), and 24 cases were reported in the placebo arm (22%). Pooled analysis resulted in a significant reduction of cancer risk in favor of the catechin arm (risk-ratio = 0.41; 95% CI: 0.19- 0.86; I2 = 0). In conclusion, our data suggest that the intake of concentrated green tea catechin preparations may confer a significant protective effect to carriers of early neoplastic lesions in the prostate. The quality of the evidence is moderate, and additional, largescale studies are warranted to substantiate these preliminary findings.</p> ER -