https://doi.org/10.4081/aiua.2022.3.319

Effects of long term sildenafil on the acute phase of Peyronie’s disease in a combination treatment

Vol. 94 No. 3 (2022)
Published: September 26, 2022
Peyronie; Oral treatment; Fibrosis; Antifibrotic treatment.
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Authors

Murat Topcuoglu
muraturo@yahoo.com
Department of Urology, Alaaddin Keykubat University Alanya Training and Research Hospital, Antalya, Turkey.
Murat Çakan
Department of Urology, Dıs¸kapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.

Objectives: The aim of this study was to investigate the impact of the addition of 50 mg daily sildenafil to pentoxifylline-colchicine combination ther-apy on the Peyronie's plaque features in patients with the acute phase of Peyronie's disease (PD).
Methods: In this retrospective and non-randomized clinical study, patients were divided into 2 groups as group 1; (n = 107) who received colchicine and pentoxyfillin plus 50 mg daily oral sildenafil, and as group 2; (n = 79) who received only colchicine and pentoxyfillin. Patients were compared in terms of degree of curvature, pain in erection and erectile function at the baseline and at 6-month follow up. Pain in erection and erectile func-tion were evaluated by visual Analogue Scale (EF-VAS), and the shortened version of the International Index of Erectile Function (IIEF-5). Improvement in the degree of curvature and change in EF-VAS scores were primary endpoints of the study. Change in IIEF-5 score was the secondary endpoint of the study.
Results: The two groups were statistically similar in terms of demographics and baseline features of PD. A statistically signifi-cant reduction in degree of curvature and EF-VAS scores was shown in group 1 compared to group 2.There was also a signifi-cantly higher IIEF-5 score in group 1 compared to group 2. No significant side effects were detected in both groups during treatment period.
Conclusions: Adding sildenafil to pentoxifylline-colchicine com-bination treatment seems to improve PD related symptoms in the acute phase PD. PDE5i may contribute to relieve the Peyronie's symptoms in ED patients through their antifibrotic effects.

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Murat Çakan, Department of Urology, Dıs¸kapı Yıldırım Beyazıt Training and Research Hospital, Ankara

0000-0002-6220-5509 orcid number

How to Cite

Topcuoglu, M., & Çakan, M. (2022). Effects of long term sildenafil on the acute phase of Peyronie’s disease in a combination treatment. Archivio Italiano Di Urologia E Andrologia, 94(3), 319–322. https://doi.org/10.4081/aiua.2022.3.319

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