Tamsulosin plus a new complementary and alternative medicine in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results from a retrospective comparative study

  • Ferdinando Fusco Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. Naples, Italy.
  • Massimiliano Creta Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. Naples, Italy.
  • Francesco Trama | francescotrama@gmail.com Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. Naples, Italy.
  • Fabio Esposito Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. Naples, Italy.
  • Felice Crocetto Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. Naples, Italy.
  • Achille Aveta Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. Naples, Italy.
  • Francesco Mangiapia Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. Naples, Italy.
  • Ciro Imbimbo Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. Naples, Italy.
  • Marco Capece Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. Naples, Italy.
  • Roberto La Rocca Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. Naples, Italy.
  • Vincenzo Mirone Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. Naples, Italy.
  • Nicola Longo Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. Naples, Italy.

Abstract

Background: We aimed to compare the efficacy of tamsulosin 0.4 mg once a day alone and the combination therapy involving tamsulosin 0.4 mg once a day plus the complementary and alternative medicine consisting of vitamins (C and D), herbal products (Cucurbita maxima, Capsicum annum, Polygonum capsicatum) and amino acid L-Glutamine bid in patients with lower urinary tract symptoms related to benign prostatic hyperplasia (LUTS/BPH).
Methods: We performed a retrospective matched paired comparison. The clinical records of LUTS/BPH patients who underwent medical therapy with tamsulosin 0.4 mg/day plus the complementary and alternative medicine consisting of vitamins (C and D), herbal products (Cucurbita maxima, Capsicum annum, Polygonum capsicatum) and amino acid L-Glutamine bid between January 2019 to September 2019 were reviewed (Group 1). These patients were compared in a 1:1 fashion with LUTS/BPH patients who underwent therapy with tamsulosin 0.4 mg/day alone (Group 2). Total, storage, voiding and Quality of Life (QoL) international prostate symptom (IPSS) score, as well as overactive bladder (OAB)-v8 score and treatment- related adverse events recorded at 40 days follow-up in both groups were compared.
Results: At 40 days follow-up mean total, storage, voiding and QoL IPSS sub-scores as well as OAB-v8 score significantly improved in both groups. Intergroup comparison showed statistically significant lower mean total IPSS score (11.6 vs 12.4, p = 0.04) mean storage IPSS sub-score (6.5 vs 7.5, p = 0.01), and mean OAB v8 score (16.7 vs 18.8, p = 0.03) in patients in the Group 1.
Conclusions: The combination of tamsulosin 0.4 mg/die plus the complementary and alternative medicine consisting of vitamins (C and D), herbal products (Cucurbita maxima, Capsicum annum, Polygonum capsicatum) and amino acid LGlutamine bid provides statistically significant advantages in terms of storage LUTS improvements in patients with LUTS/BPH compared to tamsulosin 0.4 mg/day alone. These findings are preliminary and further prospective studies on a greater number of patients are needed to confirm it.

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Published
2020-10-01
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Section
Original Papers - Incontinence & Urodynamics
Keywords:
Benign prostatic hyperplasia; Combination therapy; Lower urinary tract symptoms; Phytotherapy
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How to Cite
Fusco, F., Creta, M., Trama, F., Esposito, F., Crocetto, F., Aveta, A., Mangiapia, F., Imbimbo, C., Capece, M., La Rocca, R., Mirone, V., & Longo, N. (2020). Tamsulosin plus a new complementary and alternative medicine in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results from a retrospective comparative study. Archivio Italiano Di Urologia E Andrologia, 92(3). https://doi.org/10.4081/aiua.2020.3.173