Assesment of anogenital distance as a marker in diagnosis of prostate cancer

  • Aytac Sahin | draytacsahin@gmail.com Urology Department, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
  • Musab Ali Kutluhan Urology Department, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
  • Tuncay Toprak Urology Department, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
  • Yasin Vural Urology Department, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
  • Ahmet Ürkmez Urology Department, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
  • Serkan Akan Urology Department, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
  • Ayhan Verit Urology Department, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.

Abstract

Objectives: Anogenital distance (AGD), the distance from the sexual organs to the anus, is a sexually dimorphic feature in mammals. In this study, we investigated the relationship between anogenital distance and prostate cancer (PCa).
Methods: 52 patients diagnosed with PCa and 60 patients with benign prostate hyperplasia as a control group were included in the study. AGDAP (cephalad insertion of the penis to the center of the anus) and AGDAS (posterior base (first fold) of the scrotum to the center of the anus) measurements of patients were done and noted before biopsy.
Results: The mean ages of 52 patients diagnosed with PCa and 60 patients with benign prostatic hyperplasia (BPH) were 67.70 ± 7.74 and 67.03 ± 7.89, respectively. There was no statistically significant difference in terms of age and serum testosterone levels of the patients diagnosed with prostate cancer or BPH (p > 0.05). Mean PSA values of patients diagnosed with prostate cancer wto be statistically higher than patients with BPH (p = 0.000). The mean AGDAP measurements of patients diagnosed with prostate cancer were statistically higher than those diagnosed with BPH (p = 0.000) and there was no significant difference in AGDAS measurements.(p = 0.823; p > 0.05). Conclusions: Androgen exposure is thought to play a role in the development PCa. Also AGD may be an indicator of prenatal androgen activity. In our study, we found a direct correlation between AGDAP and PCa. In order to reach a definitive conclusion, randomized controlled trials with larger sample number are needed.

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Published
2019-10-02
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Section
Original Papers - Prostate
Keywords:
Anogenital distance, Prostate cancer, Benign prostate hyperplasia, Androgens
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How to Cite
Sahin, A., Kutluhan, M., Toprak, T., Vural, Y., Ürkmez, A., Akan, S., & Verit, A. (2019). Assesment of anogenital distance as a marker in diagnosis of prostate cancer. Archivio Italiano Di Urologia E Andrologia, 91(3). https://doi.org/10.4081/aiua.2019.3.163