Increased neutrophil/lymphocyte ratio in testicular cancer

  • Aytaç Şahin | draytacsahin@gmail.com SBU Fatih Sultan Mehmet Training and Research Hospital, Turkey.
  • Tuncay Toprak SBU Fatih Sultan Mehmet Training and Research Hospital, Turkey.
  • Musab Ali Kutluhan SBU Fatih Sultan Mehmet Training and Research Hospital, Turkey.
  • Yasin Vural SBU Fatih Sultan Mehmet Training and Research Hospital, Turkey.
  • Ahmet Ürkmez SBU Fatih Sultan Mehmet Training and Research Hospital, Turkey.
  • Ayhan Verit SBU Fatih Sultan Mehmet Training and Research Hospital, Turkey.

Abstract

Objective: Testicular cancers, which are less common than other cancers, are important in terms of being seen in young people. Physical examination, imaging, laboratory and tumor markers are used for diagnosis. There are some studies of some blood parameters that can be involved in inflammation and tumorogenesis. We retrospectively compared hematological values measured in our patients who were diagnosed with testicular tumor in comparison with patients with similar age group who underwent varicocelectomy repair.
Materials and methods: This cross-sectional retrospective study included 120 patients who underwent radical inguinal orchiectomy for testicular tumor between January 2010 and December 2018, and 171 patients who underwent varicocelectomy as a control group. Patients with an active infection and hematological disorders were excluded from the study. We evaulated hematological parameters including neutrophil (NEU), lymphocyte (LYM), platelet (PLT) count, and mean platelet volume. The study was conducted on 291 patients. divided in two groups: tumor (n = 120) and varicocele (n = 171).
Results: There was no statistically significant difference between the groups in terms of PLT / lymphocyte ratio and mean platelet volume (MPV) levels (p > 0.05). The neutrophil /lymphocyte ratio (NLR) of the tumor group was significantly higher than the varicocele group (p = 0.001; p < 0.05). There was a statistically significant difference between the tumor stages in terms of PLT / Lymphocyte ratios (p = 0.006; p < 0.05).
Conclusions: There was only a statistically significant increase in NLR values in the testicular tumor group compared to the varicocele group. Larger, randomized controlled studies are needed at this field.

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Published
2019-07-02
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Issue
Section
Original Papers - Oncology
Keywords:
Testis, Cancer, Mean platelet volume (MPV), Neutrophil/lymphocyte ratio (NLR)
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How to Cite
Şahin, A., Toprak, T., Kutluhan, M. A., Vural, Y., Ürkmez, A., & Verit, A. (2019). Increased neutrophil/lymphocyte ratio in testicular cancer. Archivio Italiano Di Urologia E Andrologia, 91(2). https://doi.org/10.4081/aiua.2019.2.97