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Desmopressin 120 mcg, 180 mcg, 240 mcg: The right treatment for the right patient

Pietro Ferrara, Ester Del Vescovo, Francesca Ianniello, Giulia Franceschini, Luciana Romaniello, Alberto Verrotti
  • Ester Del Vescovo
    Campus Bio-Medico University, Rome, Italy
  • Francesca Ianniello
    Institute of Pediatrics, Catholic University Medical School, Rome, Italy
  • Giulia Franceschini
    Campus Bio-Medico University, Rome, Italy
  • Luciana Romaniello
    San Carlo Hospital, Potenza, Italy
  • Alberto Verrotti
    Department of Pediatrics, University of L’Aquila, L’Aquila, Italy

Abstract

Background: The first-line drug therapy for patients with nocturnal enuresis (NE) associated with nocturnal polyuria and normal bladder function is desmopressin (dDAVP). Objective: To evaluate if increasing dose of oral desmopressin lyophilisate (MELT) can improve response rates to dDAVP and is useful in enuretic children.
Materials and methods: We enrolled a total of 260 children all diagnosed with NE. Enuretic children were treated with increasing MELT at a dose of 120, 180 and 240 mcg a day.
Results. We included in our study a total of 237 children, 164 males (69.2%) and 73 females (30.8%) aged between 5 and 18 years (mean age 10.32 ± 2.52 years). Of the 237 patients enrolled in the study and treated with MELT 120 mcg, a full response was achieved in 135 (56.9%). A partial response was achieved in 21 (8.9%) patients, therefore the dose was increased up to 180 mcg, with further improving symptoms (14.3%) or full response (9.5%), and up to 240 mcg, without usefulness.
Conclusions: MELT at the dose of 120 mcg resulted efficacy and safety; the increased dose up to 180 mcg resulted poorly efficacy; finally, the further increase up to 240 mcg did not improve the symptoms with the increased risk of side effects.

Keywords

Desmopressin; Nocturnal enuresis

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Submitted: 2018-02-14 17:05:01
Published: 2018-06-30 00:00:00
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Copyright (c) 2018 Pietro Ferrara, Ester Del Vescovo, Francesca Ianniello, Giulia Franceschini, Luciana Romaniello, Alberto Verrotti

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