Tadalafil versus alpha blockers (alfuzosin, doxazosin, tamsulosin and silodosin) as medical expulsive therapy for < 10 mm distal and proximal ureteral stones

  • Serdar Çelik | serdarcelik84@hotmail.com Gaziemir Nevvar Salih Isgoren Hospital, Department of Urology, Izmir, Turkey.
  • Firat Akdeniz Gaziemir Nevvar Salih Isgoren Hospital, Department of Urology, Izmir, Turkey.
  • Muge Afsar Yildirim Gaziemir Nevvar Salih Isgoren Hospital, Department of Radiology, Izmir, Turkey.
  • Ozan Bozkurt Dokuz Eylul University, School of Medicine, Department of Urology, Izmir, Turkey.
  • Merve Gursoy Bulut Gaziemir Nevvar Salih Isgoren Hospital, Department of Radiology, Izmir, Turkey.
  • Mehmet Levent Hacihasanoglu Gaziemir Nevvar Salih Isgoren Hospital, Department of Urology, Izmir, Turkey.
  • Omer Demir Dokuz Eylul University, School of Medicine, Department of Urology, Izmir, Turkey.

Abstract

Objectives: To evaluate the effect of tadalafil compared with four alpha blockers (alfuzosin, doxazosin, tamsulosin and silodosin) as medical expulsive treatment for ureteral stones in male adults.
Materials and methods: Male adults who were admitted to urology clinic with flank pain and diagnosed with non complicated < 10 mm ureteral stone on non-contrast computed tomography (NCCT) between June 2014-September 2015 were retrospectively evaluated. A total of 273 patients with ureteral stone were divided into five groups. Alfuzosin 10 mg/daily, doxazosin 8 mg/daily, tamsulosin 0.4 mg/daily, silodosin 8 mg/daily and tadalafil 5 mg/daily for 6 weeks were prescribed respectively. Stone localization, diameter, volume and Hounsfield units were noted as NCCT findings. The patients were divided into the two groups based on their stone localization as distal and mid-proximal stones. These two groups were evaluated separately. Expulsion rate were noted at the end of 6 weeks. NCCT and treatment findings were compared between five drug groups in distal and mid-proximal stones separately.
Results: Age was higher in tadalafil group in distal stones (p = 0.032). Expulsion rate was found 78.1% for alfuzosin, 75.7% for doxazosin, 76.5% for tamsulosin, 88.6% for silodosin and 90% for tadalafil in distal (p = 0.44) and 21.7%, 30%, 30%, 30% and 54.5% in mid-proximal stones (p = 0.034) respectively.
Conclusions: Expulsion rate was higher in silodosin and tadalafil for distal ureteral stones but the difference didn’t meet statistical significance. However the expulsion rate was significantly higher in tadalafil than in the other groups for mid-proximal ureteral stones. The result of this study showed that tadalafil may increases ureteric stone expulsion.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2018-06-30
Info
Issue
Section
Original Papers - Stones and Infections
Keywords:
Alpha blockers, Medical expulsive theraphy, tadalafil, Ureteral stone
Statistics
  • Abstract views: 1194

  • PDF: 638
How to Cite
Çelik, S., Akdeniz, F., Afsar Yildirim, M., Bozkurt, O., Gursoy Bulut, M., Hacihasanoglu, M., & Demir, O. (2018). Tadalafil versus alpha blockers (alfuzosin, doxazosin, tamsulosin and silodosin) as medical expulsive therapy for &lt; 10 mm distal and proximal ureteral stones. Archivio Italiano Di Urologia E Andrologia, 90(2), 117-122. https://doi.org/10.4081/aiua.2018.2.117