Comparison of three most frequently used alpha blocker agents in medical expulsive therapy for distal ureteral calculi, result of a retrospective observational study

  • Aykut Buğra Sentürk | aykutbugra@gmail.com Hitit University Corum Training and Research Hospital, Turkey.
  • Cemil Aydin Hitit University Corum Training and Research Hospital, Turkey.
  • Musa Ekici Hitit University Corum Training and Research Hospital, Turkey.
  • Muhammet Yaytokgil Rize State Hospital, Turkey.
  • Ali Akkoc Alanya Alattin Keykubat University, Turkey.
  • Mehmet Murat Baykam Hitit University Corum Training and Research Hospital, Turkey.

Abstract

Purpose: In this study, we compared the effects of three agents frequently used in daily life for medical expulsive therapy.
Materials and methods: A total of 143 patients meeting the criteria were included in the study. Patients were divided into three homogeneous drug groups which were tamsulosin group (n:48), alfuzosin group (n:47) and silodosin group (n:48). The time of stone expulsion, analgesic needs, side effects of the medicine and endoscopic intervention needs of the patients were recorded.
Results: The rate of stone expulsion was 70.8% (n:34) in tamsulosin group, 70.2% (n:33) in alfuzosin group, and 75% (n:36) in silodosin group. No significant difference was observed among the rates of stone expulsion in three groups, and the rates of stone expulsion were similar (p = 0.778). The duration of stone expulsion was significantly different in the groups (p = 0.012): the time of stone expulsion for tamsulosin was 2.33 ± 0.78 days longer than for Silodosin, indicating a significant difference. There was no significant difference between tamsulosin-alfuzosin and silodosin-alfuzosin (respectively p = 0.147, p = 0.925).
Conclusions: The results of this study showed that medical expulsive therapy by using alpha blocker agents is safe and efficacious. This option must be kept in mind for patients who do not ask for surgery as the first-step treatment for eligible patients.

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Published
2018-03-31
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Issue
Section
Original Papers - Stones and Infections
Keywords:
Urology, Ureter, Stone
Statistics
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How to Cite
Sentürk, A., Aydin, C., Ekici, M., Yaytokgil, M., Akkoc, A., & Baykam, M. (2018). Comparison of three most frequently used alpha blocker agents in medical expulsive therapy for distal ureteral calculi, result of a retrospective observational study. Archivio Italiano Di Urologia E Andrologia, 90(1), 25-28. https://doi.org/10.4081/aiua.2018.1.25